TOP2A , HELLS , ATAD2 , and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma

Chen, Dong; Maruschke, Matthias; Hakenberg, Oliver W.; Zimmermann, Wolfgang; Stief, Christian G.; Büchner, Alexander

doi:10.1016/j.urology.2016.12.050

Cited by 42 publications

(54 citation statements)

References 30 publications

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“…Although 124 patients were enrolled in this study, 37 were lost in follow-up. With a median follow-up of 13.5 months (range, 0.0-199.0 months), 13 The present results showed that high Ann Arbor stage (III/IV) and high-intermediate/high IPI score were associated with a worse OS (P=0.034 and P=0.032; Fig. 2A and B).…”

Section: Association Between Nm23 Top2a Mum-1 or Vegf Expression Ansupporting

confidence: 56%

“…Nuclear DNA topoisomerase 2-α (TOP2A) is an essential enzyme required for DNA replication and transcription, as it controls and alters the topological states of DNA (12). The overexpression of TOP2A in carcinomas has been shown to be a reliable proliferation marker and to suggest poor prognosis (12)(13)(14)(15). The same results were confirmed in mantle cell lymphoma (16), with shorter survival in patients with higher TOP2A.…”

Section: Introductionmentioning

confidence: 87%

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nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

et al. 2019

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Section: Association Between Nm23 Top2a Mum-1 or Vegf Expression Ansupporting

confidence: 56%

Section: Introductionmentioning

confidence: 87%

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

et al. 2019

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“…It was reported that TOP2A was upregulated in prostate cancer, breast cancer and serves as an indicator of a poor outcome (11,31). Previously, a number of studies have revealed that TOP2A is upregulated in CCRCC and is a poor predicative marker for pgrognosis (18,32). However, to the best of our knowledge, there are no stdies on whether TOP2A is dysregulated in PRCC.…”

Section: Discussionmentioning

confidence: 97%

“…TOP2A is absent or expressed at low levels in kidney epithelial cells (17). A previous study revealed that TOP2A was upregulated in clear cell renal cell carcinoma (CCRCC), and that its expression was predictive of a poor patient outcome (18). Therefore, the present study aimed to identify whether TOP2A was also upregulated in PRCC and its function as a cancer driver, and attempted to mine data online using a bioinformatics approach to examine the cancer panel associated with TOP2A in PRCC.…”

Section: Introductionmentioning

confidence: 99%

A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma

Dai

et al. 2018

Oncol Lett

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The aim of the present study was to investigate the function of the DNA topoisomerase IIα ( gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including cBioportal, Oncomine, OncoLnc and Search Tool for the Retrieval of Interacting Genes/Proteins were used to analyze the gene expression profile, function and regulation network in PRCC. The genes that were significantly co-expressed or mutually exclusively expressed with were identified. The genes co-expressed with were defined as a '-cancer panel', which cooperatively promotes PRCC progression. This gene panel performed well in predicting the prognosis of PRCC. In addition, the -cancer panel significantly affected the outcome of PRCC compared with clear cell renal cell carcinoma (CCRCC). The protein-protein interaction network of all genes associated with was also generated. This interaction network may provide foundation for the additional investigation of . Integrative understating of the-cancer panel may result in a novel avenue for treatment intervention in PRCC.

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“…Certain lncRNAs that exist in the network have been proven to interact with miRNA and mRNA and may be potential biomarkers in the diagnosis, therapy and prognosis of GC, including UCA1, HOTTIP, HOTAIR and H19 (45)(46)(47)(48). Additionally, a few genes from the ceRNA network, including CHRDL1, COL1A1, HOXC8 and ATAD2, have been reported to act as tumor oncogenes or suppressor genes, participating in tumor growth, invasion and metastasis (41,(49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

TCGA dataset‑based construction and integrated analysis of aberrantly expressed long non‑coding RNA mediated competing endogenous RNA network in gastric cancer

Zhang

et al. 2018

Oncol Rep

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The aberrant expression of long non-coding RNAs (lncRNAs) has been confirmed to play a pivotal role in tumor initiation and development. LncRNAs can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regulate the expression of target genes in various cancers. In the present study, the authors investigated the functions of lncRNAs as ceRNAs in gastric cancer (GC) and their implications for the prognosis. The RNA sequencing profiles of 372 tumor samples and 32 adjacent non-tumor gastric samples were downloaded from The Cancer Genome Atlas (TCGA) database. The differential expression of RNAs was identified using the ʻedgeRʼ package in R language software. Survival analysis was estimated based on Kaplan-Meier curves. The Gene Ontology biological processes and the Kyoto Encyclopedia of Genes and Genomes pathways were analyzed for differentially expressed mRNAs. Finally, a total of 999 lncRNAs, 137 miRNAs and 1629 mRNAs were identified as differentially expressed (DE) in GC with log fold change (FC) thresholds >2 and adjusted P-values <0.01. A ceRNA network was constructed with 65 DElncRNAs, nine DEmiRNAs and 24 DEmRNAs. Of the 65 DElncRNAs in the ceRNA network, nine were identified to be significantly associated with overall survival (P<0.05). A total of four DElncRNAs from the ceRNA network were validated by reverse transcription-quantitative polymerase chain reaction and revealed to be associated with tumorigenesis and/or progression. In conclusion, the results of the present study provide information on the role of the ceRNA network in GC. These identified novel lncRNAs are potential candidate biomarkers and require further studies.

show abstract

TOP2A , HELLS , ATAD2 , and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma

Cited by 42 publications

References 30 publications

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma

TCGA dataset‑based construction and integrated analysis of aberrantly expressed long non‑coding RNA mediated competing endogenous RNA network in gastric cancer

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