Tonsillectomy and the risk of inflammatory bowel disease: A systematic review and meta‐analysis

Sun, Wei; Han, Xiao; Wu, Siyuan; Yang, Chuanhua

doi:10.1111/jgh.13273

Cited by 32 publications

(38 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Campylobacter in saliva was negatively correlated with Haemophilus in tonsils. Previously, a meta-analysis suggested that tonsillectomy is associated with an increased risk of developing Crohn's disease 42 , which is a major form of inflammatory bowel disease with a high prevalence of Campylobacter, particularly in pediatric patients 43 . It remains unclear why tonsillectomy is associated with an increased risk for developing this specific inflammatory bowel disease, but it seems that the negative correlation between Campylobacter and Haemophilus in our data could be considered as one possible explanation.…”

Section: Discussionmentioning

confidence: 99%

Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia

et al. 2020

View full text Add to dashboard Cite

Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and respiratory tracts, tonsillar tissue may also be affected by microbiota from both the oral cavity (saliva) and the alimentary tract. Here, we analyzed the distribution and association of the microbial communities in the saliva and tonsils of Korean children subjected to tonsillectomy because of tonsil hyperplasia (n = 29). The microbiome profiles of saliva and tonsils were established via 16S rRNA gene sequencing. Based on the alpha diversity indices, the microbial communities of the two groups showed high similarities. According to Spearman’s ranking correlation analysis, the distribution of Treponema, the causative bacterium of periodontitis, in saliva and tonsils was found to have a significant positive correlation. Two representative microbes, Prevotella in saliva and Alloprevotella in tonsils, were negatively correlated, while Treponema 2 showed a strong positive correlation between saliva and tonsils. Taken together, strong similarities in the microbial communities of the tonsils and saliva are evident in terms of diversity and composition. The saliva microbiome is expected to significantly affect the tonsil microbiome. Furthermore, we suggest that our study creates an opportunity for tonsillar microbiome research to facilitate the development of novel microbiome-based therapeutic strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Tonsillectomy was associated with subsequent CD (OR, 1.37; 95% CI, 1.16-1.62) but not UC or IBD ( Figure 2 and Supplementary Tables 1-3). 35,36 However, antibiotic exposure may be an unmeasured confounder (individuals having tonsillectomy have often experienced previous exposure to antibiotics).…”

Section: Surgeriesmentioning

confidence: 99%

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

et al. 2019

View full text Add to dashboard Cite

Our study protocol was registered with PROSPERO (registration number: CRD42018112214). We followed a standardized methodology 7 and report findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (ie, PRISMA) 8 and Meta-analyses of Observational Studies in Epidemiology (ie, MOOSE) 9 recommendations. Search Strategy We systematically searched PubMed, Embase, and Scopus from inception through September 28, 2018, to identify metaanalyses of studies assessing the association between environmental factors and IBD. Search terms included inflammatory bowel disease, Crohn's disease, or ulcerative colitis, combined with systematic review or meta-analysis. We excluded conference abstracts, letters, editorials, and articles published in languages other than English. The reference lists of the identified meta-analyses were screened for additional eligible articles. No other restrictions were imposed.

show abstract

“…In this edition of the Journal of Gastroenterology and Hepatology, Sun et al have performed a meta-analysis of 23 observational studies (22 UC and 17 CD) in an attempt to draw more definitive conclusions as to the effect of tonsillectomy on the subsequent development of IBD. 10 The results of this meta-analysis found a significant positive association between tonsillectomy and the subsequent development of CD (OR 1.37, 95% CI: 1.16-1.62) but no relationship between tonsillectomy and UC (OR 0.94, 95% CI: 0.84-1.05). This is in direct contrast to the consistent protective effect of appendicectomy in UC seen in many case-control studies.…”

mentioning

confidence: 72%

“…In this edition of the Journal of Gastroenterology and Hepatology , Sun et al . have performed a meta‐analysis of 23 observational studies (22 UC and 17 CD) in an attempt to draw more definitive conclusions as to the effect of tonsillectomy on the subsequent development of IBD …”

Section: Inflammatory Bowel Disease Risk and The Environment: Where Tmentioning

confidence: 99%

Inflammatory bowel disease risk and the environment: Where to next?

Fulforth

Gearry

2016

J of Gastro and Hepatol

View full text Add to dashboard Cite

Tonsillectomy and the risk of inflammatory bowel disease: A systematic review and meta‐analysis

Cited by 32 publications

References 58 publications

Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia

Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Inflammatory bowel disease risk and the environment: Where to next?

Contact Info

Product

Resources

About