Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Piovani, Daniele; Danese, Silvio; Peyrin–Biroulet, Laurent; Nikolopoulos, Georgios K.; Lytras, Theodore; Bonovas, Stefanos

doi:10.1053/j.gastro.2019.04.016

Cited by 436 publications

(304 citation statements)

References 121 publications

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“…The SR/MA's quality seems to be low in many fields of medicine. Among studies published in medicine to September 2019, in which the AMSTAR 2 was used as an instrument to evaluate the quality of SR/MA, 23 of 31 papers produced results similar to our study . In the six studies, the methodological quality of most (around 60%) of SRs was critical low to low .…”

Section: Discussionsupporting

confidence: 70%

The quality of systematic reviews/meta‐analyses published in the field of bariatrics: A cross‐sectional systematic survey using AMSTAR 2 and ROBIS

Storman

Jasińska

et al. 2020

Obesity Reviews

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Summary High‐quality systematic reviews (SR) and meta‐analyses (MA) are considered to be reliable sources of information. This study aims to assess the quality of studies published as SR or MA in the field of bariatrics in 2016 and 2017. We identified SR and MA in the field of bariatrics by searching electronic databases (MEDLINE, Embase, and Cochrane Database of Systematic Reviews). Eligible studies were those identified as SR/MA in the title/abstract, which aimed to assess any outcome in patients with morbid obesity undergoing or scheduled to undergo bariatric surgery. Two authors independently reviewed all titles and abstracts, assessed full texts of potentially eligible studies, and assessed the quality of included studies. Any discrepancies were resolved by the third reviewer. We evaluated the quality and risk of bias of each SR/MA using AMSTAR 2 checklist and ROBIS tool, respectively. Seventy‐eight of 4236 references met inclusion criteria and were assessed for their quality/risk of bias. The methodological quality of 99% of all papers was classified as “critically low.” A total of 6% of the studies were at low risk of bias, and 78% were assessed as being at high risk of bias. The methodological quality of studies published in 2016 and 2017 as SR/MA is highly unsatisfactory.

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Section: Discussionsupporting

confidence: 70%

The quality of systematic reviews/meta‐analyses published in the field of bariatrics: A cross‐sectional systematic survey using AMSTAR 2 and ROBIS

Storman

Jasińska

et al. 2020

Obesity Reviews

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“…Contradictory to previous results from western studies, former smoking was associated with an increased risk of UC in Asian patients as well as in Australian patients in the ACCESS cohort . A recent umbrella review of meta‐analyses confirmed the divergent role of smoking in different ethnic groups …”

Section: Disease Course Of Ibdmentioning

confidence: 84%

“…However, this was not able to be replicated in the Asian cohort which did, however, report that daily consumption of tea or coffee was associated with a decreased risk of developing IBD . An umbrella review of meta‐analyses recently confirmed that sucrose intake, soft drinks and red meat consumption increase the risk of developing IBD, while a high intake of fiber and tea prevented the development of CD and UC, respectively …”

Section: Disease Course Of Ibdmentioning

confidence: 97%

The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

365

225

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The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of the heterogeneity of the disease and eventually assist in the discovery of novel therapeutic targets and design of preventive strategies. Comparison of population‐based data in East and West reveals that the incidence of IBD has risen rapidly in East while plateauing in West. Furthermore, the clinical presentation and course of IBD differs between East and West with more patients in East presenting with complicated disease. Considering the scarcity of population‐based data from East and the lack of studies with long durations of follow‐up, it remains to be clarified whether these differences reflect true differences in disease presentation. The effects of genetic and environmental risk factors contributing to IBD also differ between Eastern and Western populations. Considering the differential effects of genetic and environmental risk factors in East and West, future studies should seek to discover novel genetic and environmental risk factors which might specifically apply to eastern populations. In this narrative review, we compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population‐based cohort studies in the last ten years. Furthermore, we look at differences in genetic susceptibility and environmental triggers of IBD between East and West.

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“…In particular, low‐ and low‐middle income countries will need accurate estimates of the IBD burden in the next future to help healthcare planning and strategies to adapt their healthcare systems to increased disease occurrence. Finally, well‐recognised risk factors of IBD should be progressively validated and integrated into the ensemble model of the GBD Study. This would allow to calculate attributable risk fractions permitting the development of predictive models of the IBD burden.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease: estimates from the global burden of disease 2017 study

Piovani

Danese

Peyrin–Biroulet

et al. 2019

Aliment Pharmacol Ther

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Summary Background Inflammatory bowel disease (IBD) is a significant health problem in the industrialised world, currently increasing in developing countries. Understanding the global burden of IBD is important to tackle increasing disease occurrence. Aim To investigate the GBD (Global Burden of Disease) 2017 Study Database summarising and critically evaluating the global burden of IBD Methods We presented age‐standardised prevalence estimates, disability‐adjusted life years (DALYs) and its components: years lived with disability (YLDs) and years of life lost (YLLs) due to premature mortality. We reported these measures from 1990 to 2017 and stratified by region, socio‐demographic index (SDI), gender and age group. Results The latest IBD prevalence and burden estimates varied widely across regions, and were particularly elevated in high‐SDI countries. Despite an increasing prevalence from 1990 to 2017 (+6%), the IBD burden decreased (DALYs −12%). This decrease was driven by IBD‐associated premature mortality (YLLs −26%). This measure represented a high share of disease burden in low‐SDI countries (86% of DALYs), whereas disability constituted the predominant component in high‐SDI countries (71%) in 2017. Disease burden decreased particularly in children (DALYs −39% and YLLs −52%). In the last 10 years, however, prevalence plateaued in middle‐ to high‐SDI countries and steeply increased in low‐SDI countries. Conclusions These findings highlight significant improvements in IBD care in the last three decades, particularly in children. The global burden of IBD and premature mortality have progressively decreased. The increase in disease frequency observed in developing countries is worrying, especially considering the high associated premature mortality in these areas.

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Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Cited by 436 publications

References 121 publications

The quality of systematic reviews/meta‐analyses published in the field of bariatrics: A cross‐sectional systematic survey using AMSTAR 2 and ROBIS

The quality of systematic reviews/meta‐analyses published in the field of bariatrics: A cross‐sectional systematic survey using AMSTAR 2 and ROBIS

The epidemiology of inflammatory bowel disease: East meets west

Inflammatory bowel disease: estimates from the global burden of disease 2017 study

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