1988
DOI: 10.1152/ajprenal.1988.255.6.f1107
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Tonic inhibition of renal response to vasopressin by a pertussis toxin substrate

Abstract: The putative role of the inhibitory guanine nucleotide binding protein (Gi) in modulating the renal response to vasopressin was investigated using islet activating protein (IAP). IAP treatment in rats in vivo abolished the capacity of alpha 2-adrenoceptors to reverse vasopressin-induced adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in microdissected cortical collecting tubule (CCT) segments. IAP pretreatment also caused a marked upward shift in the dose-response curve of vasopressin (10(-10) to 10(-… Show more

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“…In previous studies, both pertussis-toxin-sensitive and -insensitive effects of adrenaline have been reported: adrenaline binding and stimulation of phosphorylase in hepatocytes [24], as well as adrenaline binding and stimulation of phosphoinositide hydrolysis and prostaglandin E2 formation in MDCK cells [25], were found to be insensitive to pretreatment with pertussis toxin. On the other hand, noradrenaline-induced inhibition of Ca 2+ channels in dorsal root ganglion neurons [26], adrenaline-induced inhibition of adenylate cyclase [27][28][29][30][31], inhibition of insulin secretion [32,33] and stimulation of phosphoinositide turnover [34] have been reported to be blocked by pertussis toxin.…”
Section: Discussionmentioning
confidence: 99%
“…In previous studies, both pertussis-toxin-sensitive and -insensitive effects of adrenaline have been reported: adrenaline binding and stimulation of phosphorylase in hepatocytes [24], as well as adrenaline binding and stimulation of phosphoinositide hydrolysis and prostaglandin E2 formation in MDCK cells [25], were found to be insensitive to pretreatment with pertussis toxin. On the other hand, noradrenaline-induced inhibition of Ca 2+ channels in dorsal root ganglion neurons [26], adrenaline-induced inhibition of adenylate cyclase [27][28][29][30][31], inhibition of insulin secretion [32,33] and stimulation of phosphoinositide turnover [34] have been reported to be blocked by pertussis toxin.…”
Section: Discussionmentioning
confidence: 99%