Tongue force and tongue motility are differently affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats

Nuckolls, Andrea L.; Worley, C.M.; Leto, Christopher; Zhang, Hongyu; Morris, Jill K.; Stanford, John A.

doi:10.1016/j.bbr.2012.07.003

Cited by 27 publications

(28 citation statements)

References 47 publications

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“…The SOD1-G93A transgenic rodents are validated models of oral-stage dysphagia for bulbar deficits of Amyotrophic Lateral Sclerosis [28, 32]. There are multiple models of Parkinson’s disease, including (6-OHDA)-induced DA depletion [8, 37], surgical lesions [42] and PINK KO genetic models [22, 23]. Surgical or pharmacological models of stroke in rodents have been common, but are now being developed and validated for examining dysphagia [19, 44].…”

Section: Ceteris Paribus and Understanding Pathophysiologymentioning

confidence: 99%

Animal Models for Dysphagia Studies: What Have We Learnt So Far

et al. 2017

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Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia. The first is a more complete characterization of the physiology of both normal and pathological swallow than is possible in human subjects. The second is suggesting of specific, physiological, targets for development and testing of treatment interventions to improve dysphagia outcomes.

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Section: Ceteris Paribus and Understanding Pathophysiologymentioning

confidence: 99%

Animal Models for Dysphagia Studies: What Have We Learnt So Far

et al. 2017

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“…Factors other than nigrostriatal DA may also play a role in age-related tongue motility deficits, however. For example, we recently reported that bilateral nigrostriatal DA depletion does not reduce tongue motility in young adult rats (Nuckolls, et al, 2012). Furthermore, our current results with GBR-12909, and our previous results with nomifensine (Stanford et al, 2003), suggest that increasing extracellular DA by blocking its reuptake does not improve tongue motility in aged rats.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats

et al. 2014

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Rationale Orolingual motor deficits, such as dysarthria and dysphagia, contribute to increased morbidity and mortality in the elderly. In preclinical studies we and others have reported age-related decreases in tongue motility in both F344 and F344/BN rats. The fact that these deficits are associated with nigrostriatal dopamine (DA) tissue measures suggests that increasing dopamine function might normalize tongue motility. Objective The purpose of the current study was to determine whether two indirect dopamine agonists with locomotor-enhancing effects, d-amphetamine (amphetamine; 1 & 2 mg/kg) and GBR-12909 (5, 10, and 20 mg/kg), can improve tongue motility in aged F344/BN rats. Methods Young (6 months) and aged (30 months) F344/BN rats licked water from an isometric force disc so that tongue motility (licks/second) and tongue force could be measured as a function of age and drug dose. Results Consistent with our previous studies, tongue force was greater and tongue motility was lower in the aged group. Tongue motility was increased by amphetamine but not by GBR-12909. Amphetamine decreased peak tongue force, primarily in the young group. GBR-12909 did not affect tongue force. GBR-12909 increased the number of licks/session in the young group but not in the aged group, while amphetamine increased this measure in both groups. Conclusion These results demonstrate differential effects of these drugs on orolingual motor function and suggest that blocking DA uptake is insufficient to increase tongue motility in aging.

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“…A recent study compared unilateral to bilateral dopamine depletion in a licking task akin to the one used in the current study. [34] Both unilateral and bilateral lesions caused reductions in licking force, however, only the unilateral lesion group showed deficits in tongue motility. [34] These results suggested that unilateral deficits can represent an interhemispheric imbalance in terms of sensorimotor control.…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease

Ciucci

Schaser²,

Russell³

2013

Behavioural Brain Research

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Unilateral lesions to the medial forebrain bundle with 6-hydroxydopamine (6- OHDA) lead to force and timing deficits during a complex licking task. We hypothesized that training targeting tongue force generation during licking would improve timing and force measures and also lead to striatal dopamine sparing. Nine month-old male Fisher344/Brown Norway rats were used in this experiment. Sixteen rats were in the control condition and received tongue exercise (n=8) or no exercise (n=8). Fourteen rats were in the 6-OHDA lesion condition and underwent tongue exercise (n=7) and or no exercise (n=7). Following 4 weeks of training and post-training measures, all animals underwent bilateral stimulation of the hypoglossal nerves to measure muscle contractile properties and were then transcardially perfused and brain tissues collected for immunohistochemistry to examine striatal dopamine content. Results demonstrated that exercise animals performed better for maximal force, average force, and press rate than their no-exercise counterparts, and the 6-OHDA animals that underwent exercise performed as well as the control no exercise group. Interestingly, there were no group differences for tetanic muscle force, despite behavioral recovery of forces. Additionally, behavioral and neurochemical analyses indicate that there were no differences in striatal dopamine. Thus, targeted exercise can improve tongue force and timing deficits related to 6-OHDA lesions and this exercise likely has a central, versus peripheral (muscle strength) mechanism. However, this mechanism is not related to sparing of striatal dopamine content.

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Tongue force and tongue motility are differently affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats

Cited by 27 publications

References 47 publications

Animal Models for Dysphagia Studies: What Have We Learnt So Far

Animal Models for Dysphagia Studies: What Have We Learnt So Far

Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats

Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease

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