Abstract:Rationale
Orolingual motor deficits, such as dysarthria and dysphagia, contribute to increased morbidity and mortality in the elderly. In preclinical studies we and others have reported age-related decreases in tongue motility in both F344 and F344/BN rats. The fact that these deficits are associated with nigrostriatal dopamine (DA) tissue measures suggests that increasing dopamine function might normalize tongue motility.
Objective
The purpose of the current study was to determine whether two indirect dopam… Show more
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