Breast cancer is the leading cause of mortality and morbidity in females worldwide. Combating this, needs early detection of malignancy and prompt management. Various modalities available are-digital mammography +/tomosynthesis (DBT), ultrasound with colour Doppler and elastography, dynamic contrast enhanced MRI (DCE-MRI) with MRI being considered as the best. This study was done to compare efficacy of digital breast tomosynthesis and MRI breast in evaluation of palpable breast masses and other suspicious breast findings. Material and methods: A prospective study of 50 patients was carried out in the Department of Radio-diagnosis, Government Medical College, Kota [Rajasthan]. Females (20-72 years) with clinically palpable breast lump/nipple erosion/ nipple retraction/nipple discharge / for screening purposes / BI-RADS 3,4,5 were included. Cases on chemotherapy/ radiotherapy /post operative cases/recent biopsy done from the lesion/painful breast lesions/any contraindication to MRI /pregnant females/ BIRADS 1,2,6 were excluded. DBT and MRI was performed in each patient and results were correlated with histopathology. Results: Well circumscribed margins was most commonly associated with benignity Spiculated margins and gross architectural distortion(seen on both DBT and MRI), fine pleomorphic/grouped/linear/segmental/amorphous calcifications (seen on DBT),rim enhancement of mass with kinetic curve III, clumped/linear/segmental/focal non mass like enhancement (coinciding with calcifications on DBT), adjacent invasion and metastasis were associated with malignancy. Conclusion:Differentiation between benign and malignant lesions by DBT had 77.2% specificity with DCE-MRI having 95.45% specificity.Difference was statistically significant (Chi-square = 29.429 with 1 degree of freedom; P <0.001S).