Tomatoes have natural anti-thrombotic effects

Abstract

The prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet may be an important risk factor for thrombotic events. The daily intake of an anti-thrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to test tomato extracts for anti-thrombotic effects and to identify those varieties that have such an effect. A shear-induced platelet-function test (haemostatometry) was used to test anti-thrombotic potential in vitro. Extracts from those tomato varieties that showed a significant anti-thrombotic activity in vitro were further assessed in vivo, using a laser-induced thrombosis test in mice. One tomato variety (KG99-4) showed significant anti-thrombotic activity both in vitro and in vivo. KG99-4 inhibited not only platelet-rich thrombus formation but also had a thrombolytic effect. It is concluded that haemostatometry can detect and classify the anti-thrombotic potential of fruits and vegetables and offers a simple way of screening for such effects.

Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.)

“…It has been observed that the tomato has platelet antiaggregation activity in vitro and in vivo by inhibiting platelet aggregation induced by ADP and collagen (75)(76)(77)(78)(79)(80). This finding has also been confirmed by our research group (71).…”

Effect of Tomato Industrial Processing (Different Hybrids, Paste, and Pomace) on Inhibition of Platelet Function In Vitro, Ex Vivo, and In Vivo

“…The antiplatelet activity ex vivo was similar to that observed by Yamamoto et al, who showed that intake of tomato components with in vitro antiplatelet activity affects ex vivo platelet function in a dose-dependent manner. 21 Meanwhile, O'Kennedy et al observed antiplatelet activity 3 h after eating tomato fractions. 12 Given the involvement of platelets in atherogenesis, from early stages of this process, together with other cardioprotective functions of bioactive compounds in tomatoes, and reduction of low density lipoprotein and decreased blood pressure.…”

“…21 The aqueous extract of pomace, compared with aqueous extracts of fresh tomatoes and pasta, showed greater inhibitory activity of platelet aggregation. The aqueous extract of pomace, compared with aqueous extracts of fresh tomatoes and pasta, showed greater inhibitory activity of platelet aggregation.…”

New Developments in Lycopene Analysis by Spectroscopic and Chromatographic Techniques, Accompanied With Mathematical Modelling

“…Tests were performed in vitro and evaluated in vivo, by testing laser-induced thrombosis in mice. One of the tomato varieties tested (KG99-4) showed a significant antithrombotic activity both in vitro and in vivo, inhibiting not only thrombus formation but also showing a thrombolytic effect [98]. The intake of tomato products is effective in preventing lipid peroxidation, a risk factor for atherosclerosis and CVD.…”