Tomato pomace powder ameliorated cisplatin-induced microanatomical alterations in brain of Wistar rats

Owoeye, Olatunde; Onwuka, SK

doi:10.4314/ijbcs.v9i1.1

Cited by 6 publications

(4 citation statements)

References 19 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histological examination of hippocampus sections in group II (MSG) showed degenerative changes in the pyramidal and granule cells of CA1, CA3 and dentate gyrus however some cells appeared with pale-staining nuclei. Similar findings were reported by Owoeye and Onwuka, 2015 [21] .…”

Section: Discussionsupporting

confidence: 92%

The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced hippocampal changes in albino rats: (Histological and immuno-histochemical study)

Fotouh

Sayed

Altayeb

et al. 2020

Egyptian Journal of Histology

View full text Add to dashboard Cite

Background: Food additives are substances added to food to improve its safety, freshness, taste, texture, or appearance. They include aroma enhancer eg : monosodium glutamate(MSG) or sweetener eg.: aspartame (ASP). Aim of the Study: This current study was performed to study the microscopic alterations induced by MSG, ASP individually and in combination and the possible protective effect of astaxanthin (AST) on those induced changes. Materials and Methods: Forty nine adult male albino rats were used in this study divided into; control group (fourteen rats) two rats for each experimental group and experimental group (thirty five rats) subdivided into seven subgroups:ASP group, MSG group, ASP andMSG group,AST group,ASP andAST group, MSG andAST group, ASPandMSG andAST group. Oral administration was done in the morning daily for 6 weeks for all groups. When the duration of the study ended, blood samples were collected from rat tail and paraffin sections were prepared from the cerebral hemisphere of each animal. They were subjected to hematoxylin and eosin stain and immunohistochemical stain for Caspase3 and Glial Fibrillary Acidic Protein (GFAP). Statistical analysis were done for assessment of body weight, reduced glutathione (GSH) and tumor necrosis factor α (TNF-α) level. Results: The groups that received ASP (I), MSG (II) individually or in combination (III) exhibited shrunken cells with darkly stained nuclei and surrounded with pericellular haloes and some areas even revealed loss of the cells with increase in immunoreactivity for GFAP and Caspase 3. These groups also showed elevation in the level of TNFα and decrease in the level of GSH. On treatment with AST groups V, VI and VII showed reduced pycknosis, decreased immunoreactivity for GFAP and Caspase 3. It also showed reduction in the level of TNFα and increased level of GSH. Conclusion: ASP and MSG individually or in combination induce alternation in hippocampus and AST administration ameliorate those changes

show abstract

Section: Discussionsupporting

confidence: 92%

The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced hippocampal changes in albino rats: (Histological and immuno-histochemical study)

Fotouh

Sayed

Altayeb

et al. 2020

Egyptian Journal of Histology

View full text Add to dashboard Cite

show abstract

“…Histological study of brain sections of thalidomide and carboplatin-treated group showed loss of normal structure, neuronal degeneration with pyknotic nuclei, and dilation of blood capillary with hemorrhage. Similarly, cisplatin has negative effects on cerebellar cortex neurons [ 51 ]. Gulec et al [ 52 ] suggested that sufficient levels of cisplatin have been shown to cause toxicity in the brain.…”

Section: Discussionmentioning

confidence: 99%

Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

2018

View full text Add to dashboard Cite

show abstract

“…• Group I (cisplatin treated group): rats were injected with 10 mg/kg of cisplatin IP on the 6 th and the 13th days of the study [9] .…”

Section: Experimental Groupsmentioning

confidence: 99%

Effect of Cisplatin on Cerebellar Cortex of Albino Rat and Possible Protective Role of Granulocyte Colony Stimulating Factor versus Citrullus Lanatus Juice: A Histological Study

Mohsen

Ahmed

Altaib

et al. 2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

Background: Cisplatin has a major antitumor effect against a broad range of solid tumors. Yet, its clinical use is limited by its harmful effects especially on the nervous system. Aim of the Work: Assessment of the effect of cisplatin on histological structure of cerebellar cortex and the possible protective role of granulocyte colony stimulating factor (G-CSF) versus citrullus lanatus juice. Materials and Methods: Forty adult male albino rats were assigned to a group of four: Control group, group I: received cisplatin (10 mg/kg) on the 6th and 13th days of the study via intraperitoneal (IP) injection, group II: received G-CSF (50 µg/kg) for five consecutive days via subcutaneous injection then received as group I, group III: received cisplatin as group I as well as citrullus lanatus juice (4 ml/kg) daily for 16 days via oral gavage. Blood samples were taken to measure plasma malondialdehyde (MDA) and reduced glutathione (GSH) levels. Cerebellar biopsies were processed for light microscopy using H&E and immunohistochemical stains (glial fibrillary acidic protein (GFAP) & caspase-3) as well as for electron microscopy. Morphometric and statistical studies were done for number of Purkinje cells, thickness of granular layer, area percent of GFAP positive cells and optical density of caspase-3 positive cells. Results: Group I showed significantly high MDA and significantly low GSH levels, shrinkage, distortion, deep staining of disarranged Purkinje cells with nuclear pyknosis, swollen mitochondria with destroyed cristae and dilated Golgi apparatus. Separated granule cells were shrunken with dark irregular nuclei. Results were confirmed by morphometric and statistical studies. These changes were ameliorated in both group II and III with great extent in group II than in group III. Conclusion: G-CSF could improve cisplatin induced cerebellar cortical changes better than citrullus lanatus juice.

show abstract

Tomato pomace powder ameliorated cisplatin-induced microanatomical alterations in brain of Wistar rats

Cited by 6 publications

References 19 publications

The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced hippocampal changes in albino rats: (Histological and immuno-histochemical study)

The possible neuroprotective effect of astaxanthin on monosodium glutamate and aspartame induced hippocampal changes in albino rats: (Histological and immuno-histochemical study)

Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

Effect of Cisplatin on Cerebellar Cortex of Albino Rat and Possible Protective Role of Granulocyte Colony Stimulating Factor versus Citrullus Lanatus Juice: A Histological Study

Contact Info

Product

Resources

About