Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats

Ferreira, Ana Lúcia dos Anjos; Salvadori, Daisy Maria Fávero; Nascimento, Maria Carolina Munhoz Oliveira; Rocha, Noeme Sousa; Corrêa, Camila Renata; Pereira, Elenize Jamas; Matsubara, Luiz Shiguero; Matsubara, Beatriz Bojikian; Ladeira, Marcelo Sady Plácido

doi:10.1016/j.mrgentox.2007.04.003

Cited by 51 publications

(29 citation statements)

References 52 publications

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“…Tail intensity according to Comet Assay II-Perceptive Instruments is defined as ''the sum of all intensity values in the tail region less those which are part of the mirrored head region. The value is also expressed as a percentage of the total Comet or cell intensity'' (Ferreira et al 2007). …”

Section: Determination Of Oxidative Dna Damagementioning

confidence: 99%

Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

et al. 2011

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The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. The alkaline Comet assay modified with lesion-specific enzymes was used to detect single and double strand breaks, labile sites (SBs), and oxidised purines and pyrimidines. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, oxidative DNA damage was detected in the 'normal' oral epithelium. In pre-neoplastic lesions and squamous cell carcinomas induced after 12 and 20 weeks following carcinogen exposure, respectively, oxidative DNA damage was also increased (P < 0.05) when compared to negative control. In conclusion, our results suggest that oxidative DNA damage is an early event during multistep carcinogenesis assay induced by 4NQO. This kind of approach should be considered to persons with high risk of oral cancer, such as in smokers or alcohol consumers.

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Section: Determination Of Oxidative Dna Damagementioning

confidence: 99%

Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

et al. 2011

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“…Oxidative mtDNA damage has been described in cardiac myocytes from animals submitted to single and multiple doses of DOX [50][51][52]. However, only recently was DOX-induced oxidative nuclear DNA damage evaluated both in vitro (oxidised pyrimidines and 8-hydroxyguanine) [53] and in vivo (oxidised pyrimidines and purines) [54], showing direct indications of nuclear DNA lesions in cardiac myocytes. The consequences of nuclear DNA damage, such as chromosomal aberrations, gene expression changes and apoptosis, are probably relevant events in the DOX-induced cardiomyopathy pathogenesis.…”

Section: Dna Damagementioning

confidence: 99%

Anthracycline-Induced Cardiotoxicity

Ferreira

Matsubara²,

Matsubara³

2008

CHAMC

164

117

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The anthracyclines constitute a group of drugs widely used for the treatment of a variety of human tumors. However, the development of irreversible cardiotoxicity has limited their use. Anthracycline-induced cardiotoxicity can persist for years with no clinical symptoms. However, its prognosis becomes poor after the development of overt heart failure, possibly even worse than ischemic or idiopathic dilated cardiomyopathies. Due to the successful action of anthracyclines as chemotherapic agents, several strategies have been tried to prevent/attenuate their side effects. Although anthracycline-induced injury appears to be multifactorial, a common denominator among most of the proposed mechanisms is cellular damage mediated by reactive oxygen species. However, it remains controversial as to whether antioxidants can prevent such side effects given that different mechanisms may be involved in acute versus chronic toxicity. The present review applies a multisided approach to the critical evaluation of various hypotheses proposed over the last decade on the role of oxidative stress in cardiotoxicity induced by doxorubicin, the most used anthracycline agent. The clinical diagnosis and treatment is also discussed.

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“…Lycopene protection against the oxidation of DNA bases has recently been demonstrated in cardiomyocytes from rats subjected to cardiotoxicity and supplemented with lycopene in oleoresin (Ferreira et al 2007b). Examining men ( 70 years) from ten European countries, an important study showed an inverse association between risk of acute myocardial infarction (AMI) and adipose tissue level of lycopene.…”

Section: Lycopene and Diseasesmentioning

confidence: 99%

Lycopene Bioavailability and Its Effects on Health

Ferreira

Corrêa

2013

Food Quality, Safety and Technology

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Lycopene is a lipophilic carotenoid which is responsible for the red color in various fruits and vegetables and is commonly found in tomatoes. Lycopene is one of the most potent antioxidants among the dietary carotenoids mainly due to its many conjugated double bounds, and it also has the strongest singlet oxygen-quenching ability compared to other carotenoids. Besides acting as antioxidant, other mechanisms such as immune system stimulation, cell cycle regulations, gap junction communication enhancement, mutagenesis reduction, tumor cell proliferation inhibition, antitumor immune response improvement, and anti-inflammatory action have also been identified with this carotenoid. Lycopene, as a dietary source of a carotenoid, has received considerable scientific interest in several chronic diseases including cancer, cardiovascular diseases, osteoporosis, and diabetes. It is one of the major carotenoid in the diet of North Americans and Europeans. Besides tomato, lycopene is found in watermelon, guava, papaya, and apricot. The amount of lycopene in fruits and vegetables varies according to the season, stage of ripeness, variety, geographical and climatic effect, planting location, and postharvest handling and storage; in general, the more reddish the food, the greater the concentration of lycopene. The highest concentrations of lycopene are generally in the bark of food sources as compared to the pulp. Its largest concentration is found in food produced in regions with warm climates. Several factors affect the bioavailability of lycopene, such as the food processing. Ingestion of cooked tomato in oil medium increased human serum lycopene levels than consumption of unprocessed tomato juice.

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Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats

Cited by 51 publications

References 52 publications

Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Anthracycline-Induced Cardiotoxicity

Lycopene Bioavailability and Its Effects on Health

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