Toluene exposure during maturation of intraocular brain tissue transplants: Alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine

Granholm, Ann‐Charlotte; Gerhardt, Greg A.; Moore, Emma; Eriksdotter, Maria; Nylén, Per; Johnson, Ann Christin; Henschen, Andreas; Shirley, M.A.; Palmer, Michael R.; Hoffer, Barry J.; Höglund, G.; Olson, Lar̀s

doi:10.1016/0041-008x(88)90088-9

Cited by 6 publications

(1 citation statement)

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“…However, following intraperitoneal administration of toluene (200-600 mg/kg acutely, and 100-200 mg/kg for 14 days) marked behavioural effects were observed in the rat, which correlated to changes in monoamine metabolites [6,7]. Several studies have shown that short-term exposure to low concentrations of toluene (80-1000 ppm) can affect the levels and utilization of catecholamines, such as noradrenaline and dopamine [8][9][10][11][12][13][14][15][16]. The changes in catecholamine turnover may be related to changes in monoamine receptor binding [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat

et al. 1991

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SummaryThe effects of low concentrations of toluene (4~80 ppm. 3 days. 6 h/day) were investigated on spontaneous and on apomorphine-induced locomotor activity in the rat. and were correlated to effects on S(-) [N-propyl-3 H(N)]-propylnorapomorphine ([ 3 H]NPA) binding in rat neostriatal membranes. on membrane fluidity. membrane leakage. and calcium levels in synaptosomes from the frontoparietal cortex, the neostriatum and the subcortical limbic area. and on serum hormone levels. Toluene exposure (80 ppm, post-exposure delay 18 h) alone did not affect locomotor activity, but attenuated apomorphineinduced (0.05 mg/kg, s.c.) suppression of rearing. and potentiated apomorphine-induced (I mg/kg. s.c.) increases in locomotion and rearing. Toluene exposure increased the K 0 value of [3H]NPA binding without affecting the Bmax· All these effects were absent at 40 ppm of toluene or at a post-exposure delay of 42 h. Toluene exposure (80 ppm. post-exposure delay of 18 h) did not affect the serum levels of prolactin. TSH, corticosterone. or aldosterone, or synaptosomal membrane fluidity and calcium levels. whereas membrane leakage was increased in the neostriatum. The present study indicates that the reduction of D-2 receptor affinity by short-term. low-dose toluene exposure is accompanied by a reduced D-2 autoreceptor function and an enhanced postsynaptic D-2 receptor function.

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