Ketamine antagonizes hypoxia-induced dopamine release in rat striatum

Wang, Yun; Chiou, A. L.; Yang, Sung-Sen; Lin, Jiann Chyun

doi:10.1016/0006-8993(95)00758-i

Cited by 14 publications

(2 citation statements)

References 51 publications

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“…In the only in vivo examination of NMDA effect as a DA release modulator, ketamine significantly augmented the effects of amphetamine, as indexed with [ 123 I]IBZM SPET in humans (Kegeles et al, 2000). However, in pre-clinical species and in vitro studies, NMDA antagonists have also been reported to decrease, or abolish DA release induced by nicotine (Kosowski et al, 2004), painful stimuli (Wheeler, et al, 1995) and hypoxia (Wang et al, 1995). Nevertheless, investigation of the modulating effects of ketamine may prove a better strategy to detect NMDA activity than direct DA release.…”

Section: Future Directionsmentioning

confidence: 95%

Imaging of striatal dopamine release elicited with NMDA antagonists: is there anything there to be seen?

Rabiner

2007

J Psychopharmacol

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Increased release of striatal dopamine, indexed with in vivo imaging of the D(2) receptor, has been reported following an acute challenge with N-methyl-D-aspartate (NMDA) antagonist ketamine in humans. Replications of this result have not been consistently successful. The aim of this manuscript is to evaluate in vivo imaging examination of NMDA antagonism on striataL dopamine release in published reports of humans and pre-clinical species. The literature is evaluated in conjunction with insights on the effect of NMDA antagonism on dopamine release, elicited from microdialysis and tissue turnover studies, and suggestions for future studies are made.

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Section: Future Directionsmentioning

confidence: 95%

Imaging of striatal dopamine release elicited with NMDA antagonists: is there anything there to be seen?

Rabiner

2007

J Psychopharmacol

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“…The blood PO 2 , PCO 2 , and pH values in the OP1-or vehicle-treated rats were also not different from those in the urethane-anesthetized rats, without any pretreatment, as reported by our group previously. 24 Similarly, 85 minutes after the onset of MCA ligation, these parameters were not significantly altered by OP1 in an additional 8 animals studied ( Figure 5). In both groups, OP1 pretreatment elicited a small reduction in heart rate, which was of borderline significance.…”

Section: Physiological Responses To Op1mentioning

confidence: 99%

Osteogenic Protein-1 Protects Against Cerebral Infarction Induced by MCA Ligation in Adult Rats

Lin

Hoffer

Kaplan

et al. 1999

Stroke

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Background and Purpose-Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming growth factor-␤ superfamily, several of whose members possess neuroprotective activity. In this study, the neuroprotective effect of OP1 in cerebral ischemia was evaluated in adult animals. Methods-Adult male Sprague-Dawley rats were anesthetized with chloral hydrate. OP1 or vehicle was administered intracortically or intracerebroventricularly to the rats. Thirty minutes, 24 hours, or 72 hours after OP1 injection, the right middle cerebral artery (MCA) was ligated for 90 minutes. Twenty-four hours after reperfusion, animals were tested for motor behavior. The animals were subsequently anesthetized with urethane and perfused intracardially with saline. Brain tissue was removed, sliced, and incubated with 2% triphenyltetrazolium chloride to localize the area of infarction. Results-Only

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Electrochemical Studies of the Effects of Substance P on Dopamine Terminals in the Rat Striatum

Tang

Chiu²,

Wang

1998

Experimental Neurology

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Ketamine antagonizes hypoxia-induced dopamine release in rat striatum

Cited by 14 publications

References 51 publications

Imaging of striatal dopamine release elicited with NMDA antagonists: is there anything there to be seen?

Imaging of striatal dopamine release elicited with NMDA antagonists: is there anything there to be seen?

Osteogenic Protein-1 Protects Against Cerebral Infarction Induced by MCA Ligation in Adult Rats

Electrochemical Studies of the Effects of Substance P on Dopamine Terminals in the Rat Striatum

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