Toluene diisocyanate pulmonary disease: Immunopharmacologic and mecholyl challenge studies

Diisocyanate [MAK Value Documentation in German language, 1984]

“…Neuerdings werden auch immunzelluläre Mechanismen diskutiert [56][57][58][59][60]. Für pharmakologische Pathomechanismen sprechen Hemmeffekte der Isocyanate auf Cholinesterase [61,62] und auf das Adenyl-Cyclase-System [63][64][65][66]. Eine sehr seltene Form der respiratorischen Sensibilisierung durch Isocyanate ist die exogene allergische Alveolitis mit einem fieberhaften, grippeähnlichen Krankheitsbild [67][68][69][70][71][72][73].…”

Isocyanates

“…Pharmacological [57,[475][476][477] as well as immunological [234,248,[478][479][480][481][482][483] mechanisms are discussed for this clinical picture; see also [239,[484][485][486] and [62,252,[487][488][489]. In the initial stage shortness of breath, difficulty of breathing and tickle in the throat can occur in the case of reexposure.…”

Anthropogenic Compounds

“…Pharmacological [57,[475][476][477] as well as immunological [234,248,[478][479][480][481][482][483] mechanisms are discussed for this clinical picture; see also [239,[484][485][486] and [62,252,[487][488][489]. In the initial stage shortness of breath, difficulty of breathing and tickle in the throat can occur in the case of reexposure.…”