Diisocyanate [MAK Value Documentation in German language, 1984]

doi:10.1002/3527600418.mb0dicygrpd0010

The MAK‐Collection for Occupational Health and Safety 2012

DOI: 10.1002/3527600418.mb0dicygrpd0010

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Diisocyanate [MAK Value Documentation in German language, 1984]

Abstract: Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 10. Lieferung, Ausgabe 1984 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Schleichende Verschlechterung der Atemfunktion durch Isocyanate Sensibilisierung Allgemeines Tierexperimentelle Beobachtungen … Show more

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Cited by 2 publications

References 43 publications

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3‐Methyl‐5‐isopropylhydantoin als Hämoglobinaddukt desN,N‐Dimethylformamids und Methylisocyanats [Biomonitoring Methods in German Language, 2015]

Käfferlein

Angerer

Leng³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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The analytical method describes the specific determination of 3‐methyl‐5‐isopropylhydantoin (MIH), a hemoglobin adduct of N,N‐dimethylformamide. Following addition of 13 C 5 , 15 N‐3‐methyl‐5‐isopropylhydantoin ( 13 C 5 , 15 N‐MIH) as internal standard, isolated globin is subjected to acid hydrolysis for one hour at 110deg;C. After pH adjustment (pH 3–5) the hydrolysate is extracted twice with ethyl acetate. The combined extracts are washed with sodium hydrogen carbonate solution and dried under a stream of nitrogen. The residue is dissolved in ethyl acetate. An aliquot of the solution is analyzed using GC–MS. For calibration purposes, calibration standards are prepared in pooled globin. They are processed in the same way as the samples to be analyzed.

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3‐Methyl‐5‐isopropylhydantoin als Hämoglobinaddukt desN,N‐Dimethylformamids und Methylisocyanats [Biomonitoring Methods in German Language, 2015]

Käfferlein

Angerer

Leng³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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Hexamethylendiisocyanat, 2,4‐Toluylendiisocyanat, 2,6‐Toluylendiisocyanat, Isophorondiisocyanat und Diphenylmethan‐4,4′‐diisocyanat – Bestimmung von Hexamethylendiamin, 2,4‐Toluylendiamin, 2,6‐Toluylendiamin, Isophorondiamin und 4,4′‐Diaminodiphenylmethan in Urin mittels Gaschromatographie‐Massenspektrometrie [Biomonitoring Methods in German language, 2017]

Cocker

Jones

Leng³

et al. 2017

The MAK‐Collection for Occupational Health and Safety

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The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the present biomonitoring method. The described method allows the simultaneous determination of the metabolites of hexamethylene diisocyanate ( HDI ), 2,4‐toluenediamine and 2,6‐toluene diisocyanate ( TDI ), isophorone diisocyanate ( IPDI ) and methylene diphenyl diisocyanate (MDI) in human urine. After acid hydrolysis the released amines, hexamethylenediamine ( HDA ), 2,4‐, and 2,6‐toluenediamine ( TDA ), isophorone diamine ( IPDA ) and 4,4′‐methylenedianiline ( 4,4 ′ ‐MDA ) are extracted from urine, derivatised using heptafluorobutyric anhydride and quantified by NCI‐GC‐MS. The method was extensively validated and the reliability data were confirmed by independent laboratories, which have established and cross‐checked the whole procedure

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Diisocyanate [MAK Value Documentation in German language, 1984]

Cited by 2 publications

References 43 publications

3‐Methyl‐5‐isopropylhydantoin als Hämoglobinaddukt desN,N‐Dimethylformamids und Methylisocyanats [Biomonitoring Methods in German Language, 2015]

3‐Methyl‐5‐isopropylhydantoin als Hämoglobinaddukt desN,N‐Dimethylformamids und Methylisocyanats [Biomonitoring Methods in German Language, 2015]

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