Toll-Like Receptor 4 in the Rat Caudal Medulla Mediates Tooth Pulp Inflammatory Pain

Filippini, Helena Fetter; Molska, Graziella Rigueira; Zanjir, Maryam; Arudchelvan, Yamini; Gong, Siew‐Ging; Campos, Maria Martha; Avivi‐Arber, Limor; Sessle, Barry J.

doi:10.3389/fnins.2020.00643

Cited by 3 publications

(3 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, estrogen diminishes the immunity, enhancing the affinity and severity of oral inflammation [46]. Noteworthy, Filippini et al [47] disclosed that TLR central activation may participate in dental nociceptive pain transmission in pulp. Bi et al correlated temporomandibular joint-related pain to the change in estrogen levels.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

2022

View full text Add to dashboard Cite

This study aimed to assess the histological changes in the maxillary sinus and its adjacent dental tissues as pulp and periodontal ligament during pregnancy and investigate the role of estrogen hormone in these changes through the detection of estrogen receptors in these tissues. Sixteen adult female rats were used and were allocated into two groups: control non-pregnant (n = 8) and pregnant (n = 8). They were sacrificed and their heads were prepared for histological and immunohistochemical examination for estrogen receptor alpha. Our results revealed that pregnant rats revealed inflammatory changes in the sinus as thick epithelial lining, loss of cilia, swollen goblet cells, intraepithelial and interstitial edema. The lamina propria demonstrated considerable infiltration of inflammatory cells, glandular hyperplasia with vacuolar degeneration, and vascular congestion. Periodontal ligament and pulp revealed hyperemia and vascular congestion. Immunohistochemical examination of estrogen receptor alpha in the maxillary sinus and adjacent dental tissues (Periodontal ligament and pulp) in pregnant rats revealed a significant increase in its expression in all examined tissues. In conclusion, there was an increase in expression of ERα in the sinus mucosa and dental tissues during pregnancy together with slight inflammatory changes in these tissues. Hence, dentists should be aware of the effect of these changes on the pregnant women avoiding teeth extraction due to misdiagnosis of dental, periodontal or sinus pain after exclusion of true pathologies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Noteworthy, Filippini et al [ 47 ] disclosed that TLR central activation may participate in dental nociceptive pain transmission in pulp. Bi et al correlated temporomandibular joint-related pain to the change in estrogen levels.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

2022

View full text Add to dashboard Cite

show abstract

“…Gram-positive bacteria predominate over Gram-negative bacteria on the teeth of patients diagnosed with caries and/or pulpitis [ 3 , 4 ], and upregulation of TLR2 is greater than that of TLR4 in the dental pulp exposed to the oral environment [ 15 ]. Nevertheless, the contribution of TLR2 expressed in DPA neurons is not yet fully understood, while the role of TLR4 expressed in trigeminal ganglion (TG) neurons has been studied on dental pulp inflammatory pain [ 16 - 19 ].…”

Section: Introductionmentioning

confidence: 99%

Upregulation of Toll-like Receptor 2 in Dental Primary Afferents Following Pulp Injury

Lee

Park

et al. 2021

Exp Neurobiol

View full text Add to dashboard Cite

Responses of neurons in rostral ventromedial medulla to nociceptive stimulation of craniofacial region and tail in rats

et al. 2021

View full text Add to dashboard Cite

Toll-Like Receptor 4 in the Rat Caudal Medulla Mediates Tooth Pulp Inflammatory Pain

Cited by 3 publications

References 71 publications

Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

Upregulation of Toll-like Receptor 2 in Dental Primary Afferents Following Pulp Injury

Responses of neurons in rostral ventromedial medulla to nociceptive stimulation of craniofacial region and tail in rats

Contact Info

Product

Resources

About