Toll-like receptor 2 and 4 polymorphisms associated with Helicobacter pylori susceptibility and gastric cancer

Tongtawee, Taweesak; Simawaranon, Theeraya; Wattanawongdon, Wareeporn; Dechsukhum, Chavaboon; Leeanansaksiri, Wilairat

doi:10.5152/tjg.2018.17461

Cited by 20 publications

(20 citation statements)

References 29 publications

(27 reference statements)

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“…There are nine studies on rs3804099 polymorphism including a total of 3456 cases and 4574 controls [13][14][15][16]18,[37][38][39][40]. According to overall analysis, rs3804099 significantly decreased cancer risk [BA vs. AA (OR = 0.827, 95% Cl = 0.717-0.952, P=0.008), BB+BA vs. AA (OR = 0.85, 95% Cl = 0.744-0.97, P=0.016)] (Figure 3).…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…Thus, we can conclude that a subgroup analysis by ethnicity suggests that rs4696480 is related to cancer risk in Caucasians, but not in other ethnic groups ( Table 2 and Supplementary Figure S1). For rs3804100 polymorphism, we collected eight publications which contained 2842 cases and 3081 controls [1,[13][14][15][16]18,38,41]. But only in hospital-based analysis we found the model of BB vs. BA+AA (OR = 1.449, 95% Cl = 1.031-2.036, P=0.033) added to the risk of cancer.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…For rs3804099 (c.597T>C) and rs3804100 (c.1350T>C), Etokebe et al [13] and Semlali et al [14] found no association between these two SNPs and breast cancer; Tongtawee et al [15] demonstrated that rs3804099 and rs3804100 had no relationship with gastric cancer. However, the study of Xie et al [16] found that the risk of hepatocellular carcinoma in TLR2 rs3804099 and rs3804100 carriers was reduced.…”

Section: Introductionmentioning

confidence: 99%

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-196 to -174del, rs4696480, rs3804099 polymorphisms of Toll-like receptor 2 gene impact the susceptibility of cancers: evidence from 37053 subjects

et al. 2019

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Relationship between Toll-like receptor-2 (TLR2) and cancer risk has been illustrated in some studies, but their conclusions are inconsistent. Therefore, we designed this meta-analysis to explore a more accurate conclusion of whether TLR2 affects cancer risks. Articles were retrieved from various literature databases according to the criteria. We used STATA to calculate the odds ratio (OR) and 95% confidence interval (95% CI) to evaluate the relationship between certain polymorphism of TLR2 and cancer risk. Finally, 47 case-control studies met the criteria, comprising 15851 cases and 21182 controls. In the overall analysis, people are more likely to get cancer because of -196 to -174del in TLR2 in all five genetic models, B vs. A (OR = 1.468, 95% Cl = 1.129-1.91, P=0.005); BB vs. AA (OR = 1.716, 95% Cl = 1.178-2.5, P=0.005); BA vs. AA (OR = 1.408, 95% Cl = 1.092-1.816, P=0.008); BB+BA vs. AA (OR = 1.449, 95% Cl = 1.107-1.897, P=0.007); BB vs. BA+AA (OR = 1.517, 95% Cl = 1.092-2.107, P=0.013). Meanwhile, rs4696480 could significantly increase the risk of cancer in Caucasians, furthermore, rs3804099 significantly decreased cancer risk in overall analysis, but more subjects are necessary to confirm the results. All in all, this meta-analysis revealed that not only -196 to -174del increased the risk of among overall cancers, Caucasians are more likely to get cancer because of rs4696480, while rs3804099 polymorphism could reduce the risk of cancer in some genetic models. There is no direct evidence showing that rs5743708, rs3804100 and rs1898830 are related to cancer.Up to October 2019, PubMed, Embase, Google Scholar, Web of Science, Wanfang database and CNKI database were used by two investigators for article identification. We used the following strategy for the searching of relevant citations: (TLR2 OR (Toll-like receptors-2) OR CD282) AND (cancer OR tumor OR carcinoma OR neoplasms OR malignancy) AND (polymorphism OR mutation OR variant OR SNP OR genotype). Since the present study is a meta-analysis, no institutional review board approval and patient consent were required.

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Section: Meta-analysis Resultsmentioning

confidence: 99%

Section: Meta-analysis Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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-196 to -174del, rs4696480, rs3804099 polymorphisms of Toll-like receptor 2 gene impact the susceptibility of cancers: evidence from 37053 subjects

et al. 2019

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“…TLR6 is suggested to have an anticancer function, as described in the literature for colon cancer [54]. TLR2 and TLR4 have been associated with gastric cancer [55].…”

Section: Phagocytosismentioning

confidence: 87%

Digital Gene Expression Analysis of Epithelioid and Sarcomatoid Mesothelioma Reveals Differences in Immunogenicity

Brčić

Mathilakathu

Walter

et al. 2021

Cancers

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Malignant pleural mesothelioma (MPM) is an aggressive malignancy associated with asbestos exposure. Median survival ranges from 14 to 20 months after initial diagnosis. As of November 2020, the FDA approved a combination of immune checkpoint inhibitors after promising intermediate results. Nonetheless, responses remain unsatisfying. Adequate patient stratification to improve response rates is still lacking. This retrospective study analyzed formalin fixed paraffin embedded specimens from a cohort of 22 MPM. Twelve of those samples showed sarcomatoid, ten epithelioid differentiation. Complete follow-up, including radiological assessment of response by modRECIST and time to death, was available with reported deaths of all patients. RNA of all samples was isolated and subjected to digital gene expression pattern analysis. Our study revealed a notable difference between epithelioid and sarcomatoid mesothelioma, showing differential gene expression for 304/698 expressed genes. Whereas antigen processing and presentation to resident cytotoxic T cells as well as phagocytosis is highly affected in sarcomatoid mesothelioma, cell–cell interaction via cytokines seems to be of greater importance in epithelioid cases. Our work reveals the specific role of the immune system within the different histologic subtypes of MPM, providing a more detailed background of their immunogenic potential. This is of great interest regarding therapeutic strategies including immunotherapy in mesothelioma.

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“…Each TLR, either as a single-player or as a team, could participate in the development of a specific type of tumour. When it comes to oral and gastrointestinal cancers, the first TLR that comes to mind is TLR2 26. TLR3 has shown to participate in the pathogenesis of neuroblastoma, breast adenocarcinoma, hepatocellular, papillary thyroid, nasopharyngeal and lung carcinomas 27.…”

mentioning

confidence: 99%

Toll‐like receptors (TLRs): An old family of immune receptors with a new face in cancer pathogenesis

Mokhtari

Pourbagheri‐Sigaroodi

Zafari

et al. 2020

J Cellular Molecular Medi

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Innate immunity not only represents the first line of defence against invading microbial pathogens but also is the first step towards the activation and stimulation of adaptive immunity. Upon exposure to bacteria, viruses, protozoa and fungi, innate immune cells including neutrophils, monocytes, macrophages, dendritic cells (DCs), natural killer (NK) cells and the complement system are activated. The response of the innate immunity to microbial pathogens relies on the specific host-receptor detection of pathogen-and danger-derived molecular signatures, known as PAMPs and DAMPs, respectively. When PAMPs and DAMPs are recognized by germline-encoded pattern-recognition receptors (PRRs), different types of cytokines would be released, which in turn attract secondary defensive immune cells. In the long list of PRRs, Tolllike receptors (TLRs) are the most important ones. TLRs are one of the largest and most well-studied families of PRRs, which were first recognized in the fruit fly, Drosophila melanogaster. 1 Not only these receptors are one of the main components of innate immunity, infection diseases, and inflammatory conditions, but also they act as a bridge between innate and adaptive immunity. Apart from regulatory role in immune responses, TLRs have a hand in tissue homeostasis maintenance by regulating tissue repair and regeneration. But the mystery behind TLR functions in the cells was not limited only to these findings, and there was some evidence supporting the fact that they might have

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Toll-like receptor 2 and 4 polymorphisms associated with Helicobacter pylori susceptibility and gastric cancer

Cited by 20 publications

References 29 publications

-196 to -174del, rs4696480, rs3804099 polymorphisms of Toll-like receptor 2 gene impact the susceptibility of cancers: evidence from 37053 subjects

-196 to -174del, rs4696480, rs3804099 polymorphisms of Toll-like receptor 2 gene impact the susceptibility of cancers: evidence from 37053 subjects

Digital Gene Expression Analysis of Epithelioid and Sarcomatoid Mesothelioma Reveals Differences in Immunogenicity

Toll‐like receptors (TLRs): An old family of immune receptors with a new face in cancer pathogenesis

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