Tolerance of Porcine Renal Allografts Induced by Donor Spleen Cells and Seven Daysʼ Treatment With Cyclosporine

Tolerance to Organ Grafts in Pigs

“…They may very well have been MHC-matched because other pigs used by these authors did not reject liver allografts transplanted without immunosuppression (3), whereas MHC-mismatched livers have subsequently been clearly shown to reject under these conditions (4). They may very well have been MHC-matched because other pigs used by these authors did not reject liver allografts transplanted without immunosuppression (3), whereas MHC-mismatched livers have subsequently been clearly shown to reject under these conditions (4).…”

Prope tolerance: the future of organ transplantation—from the laboratory to the clinic

“…Some liver allograft patients can stop maintenance immunosuppression without penalty (17). A short course of cyclosporine accompanied by an infusion of donor bone marrow-derived cells can result in tolerance to experiment renal-allografts in pigs (20), and nonmyeloablative regimens can lead to tolerance of islet allografts in primates (21). Cessation can lead to prompt rejection (18,19).…”

Immunological tolerance: the liver effect

“…When the animal had passed through this unstable period successfully, skin grafts from the donor strain would be accepted indefinitely. It was suggested that a reciprocal immunological engagement between donor passenger cells, especially Kuppfer cells, but also other antigen presenting cells and reci‐pient lymphocytes reacting against the donor, resulted in an immunological truce in which potential com‐batants were either killed or became peaceful 4 …”

“…We found in kidney allografted pigs that a 7‐day course of high dosage i.v. cyclosporin could result in tolerance and this occurred in approximately 50% of animals when a gap of 48–72 h was left after the first dose before the next six doses were given 4 . At the time of kidney transplantation donor spleen cells or a blood transfusion were given.…”

“…The question has continuously been on the minds of those working in transplantation as to whether it would be possible, by the use of drugs or other conditioning agents, to change the recipient immune system, at least temporarily, to a similar state to that which occurs in embryo. We found in kidney allografted pigs that a 7 day course of high dosage intravenous cyclosporin could result in tolerance, and this occurred in approximately 50% of animals when a gap of 48-72 h was left after the first dose and before the next six doses were given (4). At the time of kidney transplantation donor spleen cells or a blood transfusion were given.…”