Tolerance of different dairy products in subjects with symptomatic lactose malabsorption due to adult type hypolactasia

Mądry, Edyta; Krasińska, Beata; Woźniewicz, Małgorzata; Drzymała-Czyż, Sławomira; Bobkowski, Waldemar; Torlińska, T; Walkowiak, Jarosław

doi:10.5114/pg.2011.25381

Cited by 2 publications

(1 citation statement)

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“…This stems from their content of b-galactosidase, the enzyme that may act in lactose digestion and may change gastric emptying and small intestine transit. [32][33][34] Additional work is needed to optimize the nutritional standards for the dairy products in CF lactose malabsorbers, so as to contribute to the prevention or reversal of poor bone health in this group of patients. CONCLUSION LM seems to be an independent risk factor for decreased BMD in CF patients.…”

Section: Discussionmentioning

confidence: 99%

Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients

et al. 2012

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As decreased bone mineral density (BMD) is a common problem in cystic fibrosis (CF) and milk products may have pivotal dietary role affecting BMD, we aimed to assess the potential influence of adult-type hypolactasia (ATH) and lactose malabsorption (LM) on BMD in adolescent and young adult patients. In 95 CF pancreatic-insufficient patients aged 10-25 years (without liver cirrhosis, steatosis and cholestasis, diabetes mellitus, systemic glucocorticoid therapy), lumbar BMD, the nutritional status, pulmonary function, vitamin D3 concentration, calcium intake and single-nucleotide polymorphism upstream of the lactase gene were assessed. In subjects with the À13910 C/C genotype predisposing to ATH, the presence of LM was determined with the use of a hydrogen-methane breath test (BT). BMD and calcium intake were significantly lower in patients with the C/C genotype (Po0.028 and Po0.043, respectively). The abnormal BMD was stated more frequently in patients with the C/C genotype (Po0.042) and with LM (Po0.007). BMD, daily calcium intake and serum vitamin D concentration were significantly lower in LM subjects than in the other patients (Po0.037, Po0.000004 and Po0.0038, respectively). In logistic regression analysis, the relationship between examined parameters and BMD, was found to be statistically significant (Po0.001). However, only standardized body weight and LM were documented to influence BMD (Po0.025 and Po0.044, respectively). In conclusion, LM seems to be an independent risk factor for decreased BMD in CF patients.

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Section: Discussionmentioning

confidence: 99%