Tolerability of 3.5 versus 2.5 High&amp;ndash;Energy Transurethral Microwave Thermotherapy

Francisca, E.A.E.; Kortmann, Barbara; Floratos, D.; Kiemeney, Lambertus A.; Debruyne, F. M. J.; Rosette, Jean J.M.C.H. de la

doi:10.1159/000020253

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Our analgesia and sedation protocol ensured a high tolerance of the treatment, with only few patient complaints of pain during the microwave application, none of which required a treatment interruption, as reported in the literature [20]. Moreover, as a result of our experiences, since the original study we have introduced a new analgesia protocol based on intravenous administration of 100 mg tramadol hydrochloride i.v.…”

Section: Discussionmentioning

confidence: 93%

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’

Pace

Selvaggio²,

Palumbo³

et al. 2001

Eur Urol

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Section: Discussionmentioning

confidence: 93%

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’

Pace

Selvaggio²,

Palumbo³

et al. 2001

Eur Urol

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“…Tolerability of this new high-energy protocol is high, in our opinion, and it is better than the old protocol, 2.5, because of the shorter treatment time [8,9].…”

Section: Discussionmentioning

confidence: 76%

“…The system for TUMT consists of a microwave generator, a urethral treatment catheter with a microwave antenna and a fiberoptic temperature monitoring system (accuracy B 0.1°C) inside the catheter and in a rectal probe [8,9]. Computer software with 30 min duration and a maximum microwave energy of 80 W controls the microwave generator and the cooling system in response to preset temperatures of the rectal and urethral thermosensors.…”

Section: Methodsmentioning

confidence: 99%

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30-Minutes-Tumt

Dicuio¹,

Knutson²,

Veselý³

et al. 2004

Urol Int

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Introduction: Primary objective: to investigate if 30-MINUTES-TUMT can be performed under topical anesthesia and analgesics. Secondary objectives: to evaluate retrospectively analgesics and to study parameters connected with pain. Materials and Methods: Eighty-nine patients underwent TUMT. Patients were divided into four groups with different medications. Paracetamol and tolterodin-L-tartrate were administered in all groups. The first group was also given hydromorphone hydrochloride and atropine sulphate, the second group dextropropoxyphene, the third group morphine and diclofenac, and the fourth group morphine and dextropropoxyphene. Pain during TUMT was registered using the VAS scale. Results: Pain during TUMT was (VAS in mm), respectively, total-first-second-third-fourth group: at 5 min –30, 31, 12, 28, 35; at 15 min –30, 23, 16, 25, 34; at 25 min –30, 28, 18, 25, 35. All patients accepted the treatment. No significant difference between the different drug schedules was noticed. Conclusions: It is possible to treat patients with 30-MINUTES-TUMT with local anesthesia and analgesics. The pain can be accepted by all patients.

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“…For example, the Prostatron (EDAP-Technomed) uses a 1296-MHz frequency, while the T3 (Urologix) and Urowave (Dornier) use a 915-MHz frequency. 62 For surgical therapy, the microwaves are emitted from a flexible antenna. Microwave energy can be used for coagulation as well as ablation; it has been employed for hemostasis in open 63 and laparoscopic [64][65][66][67] partial nephrectomies.…”

Section: Microwave Thermotherapymentioning

confidence: 99%

Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

Rehman

Landman

Lee

et al. 2004

Journal of Endourology

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"Needle-based ablation of renal parenchyma using microwave, cryoablation, impedance-and temperature-based monopolar and bipolar radiofrequency, and liquid and gel chemoablation: Laboratory studies and review of the literature." Journal of Endourology.18,1. 83-104. (2004 ABSTRACTBackground and Purpose: Small renal tumors are often serendipitously detected during the screening of patients for renal or other disease entities. Rather than perform a radical or partial nephrectomy for these diminutive lesions, several centers have begun to explore a variety of ablative energy sources that could be applied directly via a percutaneously placed needle-like probe. To evaluate the utility of such treatment for small renal tumors/masses, we compared the feasibility, regularity (consistency in size and shape), and reproducibility of necrosis produced in normal porcine kidneys by different modes of tissue ablation: microwaves, cold impedance-based and temperature-based radiofrequency (RF) energy (monopolar and bipolar), and chemical. Chemoablation was accomplished using ethanol gel, hypertonic saline gel, and acetic acid gel either alone or with simultaneous application of monopolar or bipolar RF energy. Materials and Methods: A total of 107 renal lesions were created laparoscopically in 33 domestic pigs. Microwave thermoablation (N 5 12) was done using a Targis T3 (Urologix) 10F antenna. Cryoablation (N 5 16) was done using a single 1.5-mm probe or three 17F microprobes (17F SeedNet™ system; Galil Medical) (N 5 10 single probe and N 5 6 three probes); a double freeze cycle with a passive thaw was employed under ultrasound guidance. Dry RF lesions were created using custom-made 18-gauge single-needle monopolar probe with two or three exposed metal tips (GelTx) (N 5 12) or a single-needle bipolar probe (N 5 6) at 50 W of 510 kHz RF energy for 5 minutes. In addition, a multitine RF probe (RITA Medical Systems) was used in one set of studies (N 5 6). Both impedance-and temperature-based RF were evaluated. Chemoablation was performed with 95% ethanol (4 mL), 24% hypertonic saline (4 mL), and 50% acetic acid (4 mL) as single injections. In addition, chemoablation was tested with monopolar and bipolar RF (wet RF). Tissues were harvested 1 week after ablation for light microscopy.Results: In 11 of the 15 ablation techniques, there was complete necrosis in all lesions; however, three ethanol gel lesions had skip areas, three hypertonic saline gel lesions showed no necrosis or injury, and one monopolar RF and one bipolar RF lesion showed skip areas. In contrast to impedance-based RF, heat-based RF (RITA) caused complete necrosis without skip areas. All cryolesions resulted in complete tissue necrosis, and cryotherapy was the only modality for which lesion size could be effectively monitored using ultrasound imaging.

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Tolerability of 3.5 versus 2.5 High–Energy Transurethral Microwave Thermotherapy

Cited by 9 publications

References 15 publications

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’

30-Minutes-Tumt

Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

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Tolerability of 3.5 versus 2.5 High&ndash;Energy Transurethral Microwave Thermotherapy

Cited by 9 publications

References 15 publications

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol &lsquo;30&ndash;Minute TUMT&rsquo;

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol &lsquo;30&ndash;Minute TUMT&rsquo;

30-Minutes-Tumt

Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

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Product

Resources

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Tolerability of 3.5 versus 2.5 High–Energy Transurethral Microwave Thermotherapy

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’

Initial Experience with a New Transurethral Microwave Thermotherapy Treatment Protocol ‘30–Minute TUMT’