TOF diagnosis of laser accelerated, high-energy protons

Scuderi, V.; Milluzzo, G.; Doria, D.; Alejo, A.; Amico, A.G.; Booth, N.; Cuttone, G.; Green, J.S.; Kar, S.; Korn, G.; Larosa, G.; Leanza, R.; Martin, Philip; McKenna, P.; Padda, H.; Petringa, Giada; Pipek, J.; Romagnani, L.; Romano, F.; Russo, A.; Schillaci, F.; Cirrone, G.A.P.; Margarone, D.; Borghesi, M.

doi:10.1016/j.nima.2020.164364

Cited by 16 publications

(11 citation statements)

References 35 publications

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“…The TPS and the RCF are usually placed along the target-normal direction to measure the higher-energy component and used for the full beam characterization in advance of the cell irradiations. In contrast, TOF detectors (typically diamond and silicon carbide) [52,53] can be placed at various angles both in the forward and backward directions to monitor the particle flux and energy on-line during the irradiation, and detect any shot-to-shot variations [54]. A crucial task in view of meaningful radiobiological investigations is a precise measurement of the dose delivered to the cells.…”

Section: Diagnostics and Dosimetrymentioning

confidence: 99%

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Chaudhary¹,

Milluzzo

Ahmed

et al. 2021

Front. Phys.

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The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches.

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Section: Diagnostics and Dosimetrymentioning

confidence: 99%

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Chaudhary¹,

Milluzzo

Ahmed

et al. 2021

Front. Phys.

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“…After exiting the vacuum chamber, the bunch travels through an air gap of 6.5 cm in length. Then, the proton bunch passes either an aperture equipped with a timeof-flight (TOF) spectrometer [11,19,20] and a parallel plate ionization chamber (IC, X-Ray Therapy Monitor Chamber 7862, PTW Freiburg) positioned behind the aperture connected to a dosemeter (UNIDOS, PTW Freiburg) to deduce the proton bunch particle number or a collimator of variable diameter between 1 and 5 mm. The bunch then enters the I-BEAT 3D detector which is positioned 8 cm behind the aperture or the collimator, respectively.…”

Section: Experimental Set-upmentioning

confidence: 99%

Three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

Gerlach

Balling

Schmidt

et al. 2023

High Pow Laser Sci Eng

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The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution. By adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals, I-BEAT 3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual bunches. Relative changes in energy spread and lateral bunch size can also be monitored. Our experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm resolution. In addition to this three-dimensional bunch information, the signal strength correlates also with the absolute bunch particle number.

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“…On the other hand, if they had a longer range, they would cross the whole body of the detector releasing just a portion of their energy in it. In the latter case, the deposited energy does not correspond to the one possessed by the particle itself and estimated thanks to equation (2.1), thus equation (2.2) has to be corrected by a proper factor [17,18].…”

Section: High Energy Correction Factormentioning

confidence: 99%

Time-of-flight methodologies with large-area diamond detectors for the effectively characterization of tens MeV protons

Salvadori¹,

Andreoli²,

Cipriani³

et al. 2022

J. Inst.

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A novel detector based on a polycrystalline diamond sensor is here employed in an advanced time-of-flight scheme for the characterization of energetic ions accelerated during laser-matter interactions. The optimization of the detector and of the advanced TOF methodology allow to obtain signals characterized by high signal-to-noise ratio and high dynamic range even in the most challenging experimental environments, where the interaction of high-intensity laser pulses with matter leads to effective ion acceleration, but also to the generation of strong Electromagnetic Pulses (EMPs) with intensities up to the MV/m order. These are known to be a serious threat for the fielded diagnostic systems. In this paper we report on the measurement performed with the PW-class laser system Vega 3 at CLPU (∼30 J energy, ∼1021 W/cm2 intensity, ∼30 fs pulses) irradiating solid targets, where both tens of MeV ions and intense EMP fields were generated. The data were analyzed to retrieve a calibrated proton spectrum and in particular we focus on the analysis of the most energetic portion (E > 5.8 MeV) of the spectrum showing a procedure to deal with the intrinsic lower sensitivity of the detector in the mentioned spectral-range.

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TOF diagnosis of laser accelerated, high-energy protons

Cited by 16 publications

References 35 publications

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

Time-of-flight methodologies with large-area diamond detectors for the effectively characterization of tens MeV protons

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