Toehold-mediated strand displacement coupled with single nanoparticle dark-field microscopy imaging for ultrasensitive biosensing

Guo, Longhua; Xu, Shaohua; Wang, Yueliang; Yao, Yuanyuan; Chen, Lifen; Xu, Jiahui; Qiu, Bin

doi:10.1039/d1nr08030j

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…This shows that DNA has a great potential to deal with difficult mathematical problems ( Chen et al, 2023 ). DNA strand displacement (DSD) is an efficient technology for DNA computing that provides rich intelligent toolboxes and has been widely used to solve many computational problems, such as NP problem ( Lipton, 1995 ), information encryption ( Sun et al, 2023 ; Wang et al, 2022a ; Zou et al, 2022 ; Sun et al, 2023 ), nanomachines ( Junke et al, 2020 ; Zhang et al, 2023b ), intelligent drug delivery ( Wang et al, 2022b ), clinical diagnosis ( Fan et al, 2022 ; Boskovic et al, 2023 ; Márquez-Costa et al, 2023 ), and biosensors ( Dong et al, 2022 ; Xu et al, 2022 ; Sun et al, 2023 ). With the rapid development of DNA strand displacement technology, several molecular logic circuits have been designed ( Wang et al, 2020 ; Zhu et al, 2020 ; Litovco et al, 2021 ; Chen et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular circuit for exponentiation based on the domain coding strategy

Huang,

Duan,

Guo

et al. 2024

Front. Genet.

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DNA strand displacement (DSD) is an efficient technology for constructing molecular circuits. However, system computing speed and the scale of logical gate circuits remain a huge challenge. In this paper, a new method of coding DNA domains is proposed to carry out logic computation. The structure of DNA strands is designed regularly, and the rules of domain coding are described. Based on this, multiple-input and one-output logic computing modules are built, which are the basic components forming digital circuits. If the module has n inputs, it can implement 2n logic functions, which reduces the difficulty of designing and simplifies the structure of molecular logic circuits. In order to verify the superiority of this method for developing large-scale complex circuits, the square root and exponentiation molecular circuits are built. Under the same experimental conditions, compared with the dual-track circuits, the simulation results show that the molecular circuits designed based on the domain coding strategy have faster response time, simpler circuit structure, and better parallelism and scalability. The method of forming digital circuits based on domain coding provides a more effective way to realize intricate molecular control systems and promotes the development of DNA computing.

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