An electrochemical determination strategy for miRNA based on bimetallic nanozyme and toehold-mediated DNA replacement procedure

Su, Zhanying; Zhang, Li; Yu, Ying; Lin, Bixia; Wang, Yumin; Guo, Minzhe; Cao, Yujuan

doi:10.1007/s00604-023-05720-3

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Since the nanozyme is composed of platinum nanoparticles wrapped between two layers of MOF, it shows extraordinary peroxidase catalytic performance, which can decompose H 2 O 2 to produce significantly amplified electrochemical signals and achieve ultrasensitive detection of exosomal miRNA-21. Su et al constructed an electrochemical platform based on bimetallic nanozyme and tiptoe-mediated DNA replacement strategy for the sensitive detection of miRNA-21 [51]. AuPt nanoparticles (AuPt NPs) show good peroxidase properties and can catalyze H 2 O 2 to produce measurable electrochemical signals.…”

Section: Enzyme-catalyze Signal Amplificationmentioning

confidence: 99%

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Zhang

Gan

et al. 2023

Sensors

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Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated with tumor progression. Therefore, RNA tumor markers are considered as potential targets in clinical diagnosis and prognosis. Many studies show that biosensors have good application prospects in the field of medical diagnosis. The application of biosensors in RNA tumor markers is developing rapidly. These sensors have the advantages of high sensitivity, excellent selectivity, and convenience. However, the detection abundance of RNA tumor markers is low. In order to improve the detection sensitivity, researchers have developed a variety of signal amplification strategies to enhance the detection signal. In this review, after a brief introduction of the sensing principles and designs of different biosensing platforms, we will summarize the latest research progress of electrochemical, photoelectrochemical, and fluorescent biosensors based on signal amplification strategies for detecting RNA tumor markers. This review provides a high sensitivity and good selectivity sensing platform for early-stage cancer research. It provides a new idea for the development of accurate, sensitive, and convenient biological analysis in the future, which can be used for the early diagnosis and monitoring of cancer and contribute to the reduction in the mortality rate.

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Section: Enzyme-catalyze Signal Amplificationmentioning

confidence: 99%

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Zhang

Gan

et al. 2023

Sensors

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Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Wang,

Liu,

Fan

2023

Small Methods

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Nanozymes show great promise in enhancing disease biomarker sensing by leveraging their physicochemical properties and enzymatic activities. These qualities facilitate signal amplification and matrix effects reduction, thus boosting biomarker sensing performance. In this review, recent studies from the last five years, concentrating on disease biomarker detection improvement through nanozyme‐based biosensing are examined. This enhancement primarily involves the modulations of the size, morphology, doping, modification, electromagnetic mechanisms, electron conduction efficiency, and surface plasmon resonance effects of nanozymes for increased sensitivity. In addition, a comprehensive description of the synthesis and tuning strategies employed for nanozymes has been provided. This includes a detailed elucidation of their catalytic mechanisms in alignment with the fundamental principles of enhanced sensing technology, accompanied by the presentation of quantitatively analyzed results. Moreover, the diverse applications of nanozymes in strip sensing, colorimetric sensing, electrochemical sensing, and surface‐enhanced Raman scattering have been outlined. Additionally, the limitations, challenges, and corresponding recommendations concerning the application of nanozymes in biosensing have been summarized. Furthermore, insights have been offered into the future development and outlook of nanozymes for biosensing. This review aims to serve not only as a reference for enhancing the sensitivity of nanozyme‐based biosensors but also as a catalyst for exploring nanozyme properties and their broader applications in biosensing.

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Multiorbital DNA walker nanoprobe for portable photothermal detection based on H2S etching of cubic Prussian blue

Li,

Qin,

et al. 2023

Microchim Acta

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An electrochemical determination strategy for miRNA based on bimetallic nanozyme and toehold-mediated DNA replacement procedure

Cited by 4 publications

References 38 publications

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Multiorbital DNA walker nanoprobe for portable photothermal detection based on H2S etching of cubic Prussian blue

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