Tocotrienols reduce 25-hydroxycholesterol-induced monocyte–endothelial cell interaction by inhibiting the surface expression of adhesion molecules

Naito, Yuji; Shimozawa, Makoto; Kuroda, Masaaki; Nakabe, Nami; Manabe, Hiroki; Katada, Kazuhiro; Kokura, Satoshi; Ichikawa, Hiroshi; Yoshida, Norimasa; Noguchi, Noriko; Yoshikawa, Toshikazu

doi:10.1016/j.atherosclerosis.2004.11.017

Cited by 86 publications

(69 citation statements)

References 25 publications

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“…Genes Nutr (2012) 7:75-81 79 accumulates in endothelial cells to levels that are 30-50 fold greater compared with alpha-tocopherol (Naito et al 2005;Noguchi et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

Berbée

Boerma

et al. 2011

Genes Nutr

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Among the eight naturally occurring vitamin E analogs, c-tocotrienol (GT3) is a particularly potent radioprophylactic agent in vivo. Moreover, GT3 protects endothelial cells from radiation injury not only by virtue of its antioxidant properties but also by inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase and by improving the availability of the nitric oxide synthase cofactor tetrahydrobiopterin. Nevertheless, the precise mechanisms underlying the superior radioprotective properties of GT3 compared with other tocols are not known. This study, therefore, examined the differences in gene expression profiles between GT3 and its tocopherol counterpart, c-tocopherol, as well as between GT3 and a-tocopherol in human endothelial cells. Cells were treated with vehicle or the appropriate tocol for 24 h, after which total RNA was isolated and genome-wide gene expression profiles were obtained using the Illumina platform. GT3 was far more potent in inducing gene-expression changes than a-tocopherol or c-tocopherol. In particular, GT3 induced multiple changes in pathways known to be of importance in the cellular response to radiation exposure. Affected GO functional clusters included response to oxidative stress, response to DNA damage stimuli, cell cycle phase, regulation of cell death, regulation of cell proliferation, hematopoiesis, and blood vessel development. These results form the basis for further studies to determine the exact importance of differentially affected GO functional clusters in endothelial radioprotection by GT3.

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“…Genes Nutr (2012) 7:75-81 79 accumulates in endothelial cells to levels that are 30-50 fold greater compared with alpha-tocopherol (Naito et al 2005;Noguchi et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

Berbée

Boerma

et al. 2011

Genes Nutr

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“…Even though many in-vitro studies have reported tocotrienol's beneficial effect on adhesion molecules expression (Ahn et al, 2007;Naito et al, 2005;Theriault et al, 2002), ours is the only study that evaluated its role in human. However, the homocysteine elevation seen with TTMF treatment when compared to the baseline is in disagreement with a study in animals, which have demonstrated a beneficial lowering of homocysteine with tocotrienol treatment (Norsidah et al, 2013).…”

Section: Tocotrienol-tocopherol and Vitamin C In Hypercholesterolaemimentioning

confidence: 90%

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

et al. 2016

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Abstract-Aim:This study is designed to investigate the effects of tocotrienol-tocopherol mixed fraction (TTMF), vitamin C and combined TTMF-vitamin C supplementations on serum lipids and biochemical markers of inflammation and endothelial activation in hypercholesterolemic subjects in the low-risk category. Materials and Methods: 78 hypercholesterolaemic subjects (total cholesterol of  5.2 mmol/L and low-density lipoprotein 3.4 -4.9 mmol/L) in the low cardiovascular risk category according to the NCEP-ATP3 criteria were recruited. They were randomized into four treatment combination groups for a period of twelve months; (1) receiving TTMF and vitamin C, (2) receiving TTMF and placebo, (3) receiving vitamin C and placebo, and (4) receiving placebo for both. Serum fasting lipid profiles and levels of high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor-, intercellular adhesion molecule, vascular cell adhesion molecule, E-selectin and homocysteine were measured at entry and multiple time points post-randomisation. Results: There were no significant differences in percentage changes of lipid profiles and inflammatory markers between treated and placebo groups for either single or combined antioxidants supplementations. Conclusion: TTMF, vitamin C and combined TTMF-vitamin C supplementations have neutral effects on lipid profiles and biochemical markers of inflammation and endothelial activation in low risk subjects, suggesting that they offer no added advantage in the low cardiovascular risk group.

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“…The increased intracellular accumulation of a-tocotrienol when compared to a-tocopherol may also play a role in the higher potency of a-tocotrienol to inhibit the adhesiveness of endothelial cells (Noguchi et al 2003). Among the isoforms of tocotrienols, d-tocotrienols showed to exhibit a highest inhibitory action on monocytic cell adherence (Naito et al 2005). …”

Section: Monocytic Adhesion Property Of Tocotrienol In Cardioprotectionmentioning

confidence: 99%

Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation

2011

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Tocotrienols are a class of vitamin E which modulates several mechanisms associated with cardioprotection, anti-cancer, anti-diabetic, and neuroprotection. Unlike other Vitamin E-like compounds, tocotrienols possess inimitable properties. Quite a lot of studies have determined the cardioprotective abilities of tocotrienols and have been shown to possess novel hypocholesterolemic effects together with an ability to reduce the atherogenic apolipoprotein and lipoprotein plasma levels. In addition, tocotrienol has been suggested to have an antioxidant, anti-thrombotic, and antitumor effect indicating that tocotrienol may serve as an effective agent in the prevention and/or treatment of cardiovascular disease and cancer. The bioactivity exhibited is due to the structural characteristics of tocotrienols. Rich sources of tocotrienols which include rice bran, palm oil, and other edible oils exhibit protective effect against cardiovascular disorders. The conclusions drawn from the early literature that vitamin E group of compounds provides an inevitable role in cardioprotection is sustained in many more recent studies.

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Tocotrienols reduce 25-hydroxycholesterol-induced monocyte–endothelial cell interaction by inhibiting the surface expression of adhesion molecules

Cited by 86 publications

References 25 publications

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

Effects of adding tocotrienol-tocopherol mixed fraction and vitamin C on inflammatory status in hypercholesterolaemic patients in the low coronary risk category

Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation

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