Tobacco/nicotine and endogenous brain opioids

Xue, Yan; Domino, Edward F.

doi:10.1016/j.pnpbp.2007.12.012

Cited by 36 publications

(16 citation statements)

References 83 publications

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“…The opioid receptor system consists of its endogenous peptides derived from three precursors; proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) (Xue and Domino 2008). These precursors generate several peptides including β-endorphin, met- and leu-enkephalins, and dynorphins, which have varied affinities for the Gi/Go coupled opioid receptors.…”

Section: Recent Advances In Mechanisms Of Nicotine Withdrawal: Finmentioning

confidence: 99%

New mechanisms and perspectives in nicotine withdrawal

et al. 2015

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Diseases associated with tobacco use constitute a major health problem worldwide. Upon cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent individuals. Avoidance of the negative state produced by nicotine withdrawal represents a motivational component that promotes continued tobacco use and relapse after smoking cessation. With the modest success rate of currently available smoking cessation therapies, understanding mechanisms involved in the nicotine withdrawal syndrome are crucial for developing successful treatments. Animal models provide a useful tool for examining neuroadaptative mechanisms and factors influencing nicotine withdrawal, including sex, age, and genetic factors. Such research has also identified an important role for nicotinic receptor subtypes in different aspects of the nicotine withdrawal syndrome (e.g., physical vs. affective signs). In addition to nicotinic receptors, the opioid and endocannabinoid systems, various signal transduction pathways, neurotransmitters, and neuropeptides have been implicated in the nicotine withdrawal syndrome. Animal studies have informed human studies of genetic variants and potential targets for smoking cessation therapies. Overall, the available literature indicates that the nicotine withdrawal syndrome is complex, and involves a range of neurobiological mechanisms. As research in nicotine withdrawal progresses, new pharmacological options for smokers attempting to quit can be identified, and treatments with fewer side effects that are better tailored to the unique characteristics of patients may become available.

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Section: Recent Advances In Mechanisms Of Nicotine Withdrawal: Finmentioning

confidence: 99%

New mechanisms and perspectives in nicotine withdrawal

et al. 2015

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“…Nicotine has been shown to have diverse effects on the endogenous opioid system [73]. Endogenous opioids are produced in various tissues including the brain.…”

Section: Nicotine and Endogenous Opioidsmentioning

confidence: 99%

Methadone’s effect on nAChRs—a link between methadone use and smoking?

Talka

Tuominen

Salminen

2015

Biochemical Pharmacology

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“…CRF, endogenous opioids, and orexins). For details on the relevance of these diverse actions of NIC in various brain functions and in the development and maintenance of NIC dependence, (see De Biasi and Salas, 2008;Di Matteo et al, 2007;Touiki et al, 2007Touiki et al, , 2008Seth et al, 2002;Galindo-Charles et al, 2008;Rossi et al, 2005a,b;Grilli et al, 2005;Markou, 2007Markou, , 2008Liechti and Markou, 2008;Kenny et al, 2009;Hahn and Stolerman, 2005;Erhardt et al, 2000;George et al, 2007;Xue and Domino, 2008;Chen et al, 2008b;Merritt et al, 2008;Pasumarthi and Fadel, 2008).…”

Section: Relevance Of Dopamine In Nicotine Addictionmentioning

confidence: 99%