Methadone’s effect on nAChRs—a link between methadone use and smoking?

Talka, Reeta; Tuominen, Raimo K.; Salminen, Outi

doi:10.1016/j.bcp.2015.07.031

Cited by 15 publications

(10 citation statements)

References 143 publications

(165 reference statements)

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“…Treatment compliancy and variability in medication dosage are inherent issues in taking oral naltrexone and should be taken into consideration when interpreting results from studies of oral naltrexone. These findings are consistent with pharmacological studies finding an association between smoking and opioid agonists, such as methadone (Frosch, Shoptaw, Nahom, & Jarvik, 2000;Talka, Tuominen, & Salminen, 2015) and buprenorphine (Gubner, Guydish, Humfleet, Benowitz, & Hall, 2017;Pajusco et al, 2012). It is important to note that, in the current study, buprenorphine did not increase smoking, although the reduction in smoking was not as large as XR-NTX.…”

Section: Discussionsupporting

confidence: 91%

Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network

Montgomery

Winhusen

Scodes

et al. 2021

Journal of Substance Abuse Treatment

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Section: Discussionsupporting

confidence: 91%

Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network

Montgomery

Winhusen

Scodes

et al. 2021

Journal of Substance Abuse Treatment

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“…Furthermore, nAChR α 1 is predicted to involve varenicline (DB01273), dextromethorphan (DB00514), and methadone (DB00333), drugs for the relief of pain ( Eyler, 2013 ; Hooten & Warner, 2015 ; Weinbroum et al, 2000 ) and treatment of addiction ( Ali et al, 2017 ; Koyuncuoğlu & Saydam, 1990 ; Nocente et al, 2013 ). It has been revealed that these drugs interact with nAChR α 4, nAChR α 7, nAChR α 4, and nACh β 2 ( Damaj et al, 2005 ; Lee et al, 2006 ; Mihalak, Carroll & Luetje, 2006 ; Steensland et al, 2007 ; Talka, Salminen & Tuominen, 2015 ; Talka, Tuominen & Salminen, 2015 ). Thus, varenicline, dextromethorphan, and methadone could bind to the highly similar protein nAChR α 1.…”

Section: Resultsmentioning

confidence: 99%

Heterogeneous network propagation with forward similarity integration to enhance drug–target association prediction

Tangmanussukum

Kawichai²,

Suratanee

et al. 2022

PeerJ Computer Science

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Identification of drug–target interaction (DTI) is a crucial step to reduce time and cost in the drug discovery and development process. Since various biological data are publicly available, DTIs have been identified computationally. To predict DTIs, most existing methods focus on a single similarity measure of drugs and target proteins, whereas some recent methods integrate a particular set of drug and target similarity measures by a single integration function. Therefore, many DTIs are still missing. In this study, we propose heterogeneous network propagation with the forward similarity integration (FSI) algorithm, which systematically selects the optimal integration of multiple similarity measures of drugs and target proteins. Seven drug–drug and nine target–target similarity measures are applied with four distinct integration methods to finally create an optimal heterogeneous network model. Consequently, the optimal model uses the target similarity based on protein sequences and the fused drug similarity, which combines the similarity measures based on chemical structures, the Jaccard scores of drug–disease associations, and the cosine scores of drug–drug interactions. With an accuracy of 99.8%, this model significantly outperforms others that utilize different similarity measures of drugs and target proteins. In addition, the validation of the DTI predictions of this model demonstrates the ability of our method to discover missing potential DTIs.

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“…Furthermore, the endogenous opioid system is involved in the reward system of nicotine, and smokers appear to have upregulation of m opioid receptors when compared with nonsmokers. [48][49][50][51][52] Current tobacco use was an independent predictor for prolonged prescription pain medication use. This adds to the existing body of literature suggesting perception of pain and recovery after traumatic injury is altered in tobacco users.…”

Section: Discussionmentioning

confidence: 99%

Tobacco smoking is associated with more pain and worse functional outcomes after torsional ankle fracture

Audet

Benedick

Vallier

2022

OTA International: The Open Access Journal of Orthopaedic Trauma

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Objective: The purpose of this study was to assess the impact of current and remote tobacco smoking on clinical and functional outcomes after torsional ankle fracture. Methods: Nine hundred thirty-five patients treated surgically for torsional ankle fracture over 9 years were reviewed. Tobacco smoking status at the time of injury was defined as current (48.3%), former (11.7%), and nonsmoker (40.0%). Complications, unplanned secondary procedures, pain medication use, and functional outcome scores, as measured by Foot Function Index and Short Musculoskeletal Function Assessment (SMFA) surveys. Results: Mean age was 44.8 years, with 50.3% male. More than 6 months following injury current smokers were more likely than former smokers and nonsmokers to report ankle pain (67.8% vs 45.8% vs 47.5%) and to use prescription pain medicines (23.0% vs 10.4% vs 6.3%), all P < .05. Multiple logistic regression found current tobacco use to be an independent predictor for prescription pain medication use, and worse scores for the Foot Function Index, SMFA Dysfunction, and SMFA Bothersome scores, all P < .05. Complications occurred in 15.5% of all patients, and 10.7% underwent unplanned secondary operations. Tobacco smoking was not associated with more complications or secondary procedures. Conclusion: Current smokers are more likely to use prescription pain medications several months after injury and have worse patient-reported functional outcome scores after surgical treatment of torsional ankle fractures than former smokers and nonsmokers.

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Methadone’s effect on nAChRs—a link between methadone use and smoking?

Cited by 15 publications

References 143 publications

Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network

Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network

Heterogeneous network propagation with forward similarity integration to enhance drug–target association prediction

Tobacco smoking is associated with more pain and worse functional outcomes after torsional ankle fracture

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