Tobacco consumption and benzo(a)pyrene-diol-epoxide–DNA adducts in spermatozoa: in smokers, swim-up procedure selects spermatozoa with decreased DNA damage

Perrin, Jeanne; Tassistro, Virginie; Mandon, Marion; Grillo, Jean-Marie; Botta, A.; Sari-Minodier, I.

doi:10.1016/j.fertnstert.2011.02.021

Cited by 43 publications

(38 citation statements)

References 28 publications

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“…Several studies have suggested that smoking per se causes different types of sperm DNA damage [15], [16], [60], and paternal smoking seems independently associated with DNA adducts in embryos [19], childhood cancer in the offspring [31]–[34], [36], pregnancy loss [23], [24], lower pregnancy rate after assisted reproduction [22], non-genital birth defects [25], [26], [28]–[30] as well as with reduced birth weight [37]. Paternal smoking during pregnancy probably highly reflects smoking closely before conception and could thereby exert its effects through mutations or epigenetic changes in the paternal germ line by transmission to the sons.…”

Section: Discussionmentioning

confidence: 99%

“…However, smoking has damaging effect on DNA [14]–[16], and the DNA of spermatozoa has been reported to be much more sensitive to damage than DNA of oocytes [17], [18]. Paternal smoking has been reported to cause DNA adducts in embryos [19] of the same type found in sperm of smoking men [20], DNA breaks in cord blood of the offspring [21], and also seems associated with; lower pregnancy rates at assisted reproduction [22], pregnancy loss [23], [24], malformations [25]–[30] and cancer [31]–[36] as well as with reduced birth weight [37] in the offspring.…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men

et al. 2013

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BackgroundMaternal smoking during pregnancy has been reported to negatively impact sperm counts of the sons. Sufficient data on the effect of paternal smoking is lacking.ObjectivesWe wished to elucidate the impact of maternal and paternal smoking during pregnancy and current own smoking on reproductive function of the male offspring.MethodsSemen parameters including sperm DNA integrity were analyzed in 295 adolescents from the general population close to Malmö, Sweden, recruited for the study during 2008–2010. Information on maternal smoking was obtained from the Swedish Medical Birth Register, and regarding own and paternal smoking from questionnaires. The impacts of maternal, paternal and own smoking were evaluated in a multivariate regression model and by use of models including interaction terms. Totally, three exposures and five outcomes were evaluated.ResultsIn maternally unexposed men, paternal smoking was associated with 46% lower total sperm count (95%CI: 21%, 64%) in maternally unexposed men. Both paternal and maternal smoking were associated with a lower sperm concentration (mean differences: 35%; 95%CI: 8.1%, 55% and 36%; 95%CI: 3.9%, 57%, respectively) if the other parent was a non-smoker. No statistically significant impact of own smoking on semen parameters was seen.ConclusionsPrenatal both maternal and paternal smoking were separately associated with some decrease in sperm count in men of whom the other parent was not reported to smoke.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men

et al. 2013

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“…Some components of tobacco smoke-such as nicotine, cotinine, and benzo(α)pyrene can be detected in the cervical mucus (Simons et al, 1993;Prokopczyk et al, 1997;Coker et al, 2002). The possible routes of the components get access into the uterine cervix by inhalation and/or semen exposure (Kulikauskas et al, 1985;Perrin et al, 2011). These carcinogens could affect HPV DNA replication as well as modulate the HPV life cycle potentially enhancing viral persistence leading to host tissue carcinogenesis (Castellsague and Munoz, 2003;Syrjanen et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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“…Moreover, significant negative correlations were noticed between the degree of DNA damage and worsening of semen parameters (90). Chemicals such as nicotine (125), cadmium (126), lead (127) and benzopyrene (128) were specifically investigated and found to cause sperm DNA damage.…”

Section: Indications For Sdf Testingmentioning

confidence: 99%

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Agarwal¹,

Majzoub²,

Esteves³

et al. 2016

Transl. Androl. Urol.

326

415

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Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates. High SDF is also linked with recurrent spontaneous abortion (RSA) and can influence outcomes of different assisted reproductive techniques. Several studies have shown some benefit in using testicular sperm rather than ejaculated sperm in men with high SDF, oligozoospermia or recurrent in vitro fertilization (IVF) failure. Infertile men with evidence of exposure to pollutants can benefit from sperm DNA testing as it can help reinforce the importance of lifestyle modification (e.g., cessation of cigarette smoking, antioxidant therapy), predict fertility and monitor the patient’s response to intervention.

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Tobacco consumption and benzo(a)pyrene-diol-epoxide–DNA adducts in spermatozoa: in smokers, swim-up procedure selects spermatozoa with decreased DNA damage

Cited by 43 publications

References 28 publications

The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men

The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

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