Tobacco biomass hydrolysate enhances coenzyme Q10 production using photosynthetic Rhodospirillum rubrum

Tian, Yuting; Yue, Tianli; Yuan, Yahong; Soma, Pavan Kumar; Williams, Patrick D.; Machado, Peter A.; Fu, Hao; Kratochvil, Robert J.; Lo, Y. Martin

doi:10.1016/j.biortech.2010.05.020

Cited by 25 publications

(11 citation statements)

References 32 publications

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“…Alternatively, coenzyme Q10 can be obtained through microbial fermentation with Agrobacterium, Paracoccus, Rhodobacter, and Rhodotorula (Yoshida et al 1998;Athiyaman and Sankaranarayanan 2014). Although microbial fermentation produces coenzyme Q10 without optical isomers (Choi et al 2005;Corinne et al 2007), supplementation with solanesol-rich crop leaves can increase coenzyme Q10 production during microbial fermentation by up to 100 % (Tian et al 2010). Additionally, optimisation of coenzyme Q10 production for Schizosaccharomyces pombe transformation of solanesol significantly improves the ability of yeast cells to produce coenzyme Q10 (Zhao et al 2006b;Xiao et al 2010).…”

Section: Production Of Coenzyme Q10mentioning

confidence: 95%

“…Solanesol is widely used in the pharmaceutical industry as a critical intermediate for the synthesis of ubiquinone drugs (e.g., coenzyme Q10) (Zhao et al 2006b;Tian et al 2010;Xiao et al 2010;Athiyaman and Sankaranarayanan 2014). Moreover, solanesol possesses antibacterial, antifungal, antiviral, anticancer, antiinflammatory, and anti-ulcer activities (Serebryakov Fig.…”

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confidence: 99%

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Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis

et al. 2015

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Solanesol, which mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants, is a long-chain polyisoprenoid alcohol compound with nine isoprene units. Chemical synthesis of solanesol is difficult; therefore, solanesol is primarily extracted from solanaceous crops, particularly tobacco leaves. In plants, solanesol exists in both free and esterified forms, and its accumulation is influenced by genetic and environmental factors. Solanesol is widely used in the pharmaceutical industry as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2. Solanesol possesses antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities, and solanesol derivatives also have anti-oxidant and antitumour activities, in addition to other bioactivities. Solanesol derivatives can also be used for the treatment of cardiovascular disease, osteoporosis, acquired immune deficiency syndrome, and wound healing. Solanesol biosynthesis occurs in plastids of higher plants via the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. The key enzymes in solanesol biosynthesis, including 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate-reductoisomerase, isopentenyl pyrophosphate isomerase, and solanesyl diphosphate synthase, are also important regulators of the MEP pathway, and their overexpression is favourable for downstream metabolic flow, further promoting the synthesis of downstream metabolites, such as solanesol. Future studies should determine the pharmacokinetic properties of solanesol and its derivatives and investigate the metabolic pathways and regulatory mechanisms mediating solanesol biosynthesis, metabolic and genetic engineering of solanesol, the synthetic biology of solanesol, and the physiological role of solanesol. In the present review, we systematically summarise current knowledge on solanesol resources, derivatives, bioactivities and medicinal applications, metabolic pathways, and key biosynthetic enzymes.

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Section: Production Of Coenzyme Q10mentioning

confidence: 95%

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confidence: 99%

Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis

et al. 2015

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“…Among the increasing number of pharmacological uses ascribed to coenzyme Q10 are anticancer (in particular breast cancer) activity, treatment of periodontal disease, diabetes, Parkinson's, Alzheimer's, Huntington's disease, and to counteract the aging process. 52 …”

Section: Solanesolmentioning

confidence: 97%

Bioactive Compounds from Biomass

Arancon

2014

Renewable Resources for Biorefineries

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Plants display a unique metabolic plasticity that includes thousands of natural compounds. The natural compounds with various potential bioactivities from plant biomass present one of the most interesting high-value products. In this chapter, the main chemical groups of bioactive compounds isolated from widespread plant biomass with their main bioactivities are discussed. Also, the bioactive natural compounds from tobacco biomass are covered as a case study.

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“…Bule and Singhal [31] reported that MODELING PROCESS PARAMETERS FOR PRODUCTION OF CoQ10 natural precursors such as carrot juice and tomato juice enhanced the production of CoQ10 by Pseudomonas diminuta NCIM 2865. Yuting et al [32] reported that tobacco biomass hydrolysate enhances CoQ10 production using photosynthetic Rhodospirillum rubrum. In line with the reported literature for other strains, in R. glutinis also it was found that an increase in PHB concentration increased the CoQ10 production.…”

Section: Batch Studies On Coq10 Production With Phb and Soybean Oilmentioning

confidence: 99%

“…The complexity involved in this technique led to a search for a better statistical tool like response surface methodology (RSM). [32] The RSM approach involves designing the experiment, fitting experimental data to the equation. It determines the interaction among variables through statistical testing and provides necessary information for process optimization.…”

Section: Introductionmentioning

confidence: 99%

Modeling of Process Parameters for Enhanced Production of Coenzyme Q10 FromRhodotorula glutinis

Balakumaran

Meenakshisundaram

2014

Preparative Biochemistry and Biotechnology

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Coenzyme Q10 (CoQ10) plays an indispensable role in ATP generation through oxidative phosphorylation and helps in scavenging superoxides generated during electron transfer reactions. It finds extensive applications specifically related to oxidative damage and metabolic dysfunctions. This article reports the use of a statistical approach to optimize the concentration of key variables for the enhanced production of CoQ10 by Rhodotorula glutinis in a lab-scale fermenter. The culture conditions that promote optimum growth and CoQ10 production were optimized and the interaction of significant variables para-hydroxybenzoic acid (PHB, 819.34 mg/L) and soybean oil (7.78% [v/v]) was studied using response surface methodology (RSM). CoQ10 production increased considerably from 10 mg/L (in control) to 39.2 mg/L in batch mode with RSM-optimized precursor concentration. In the fed-batch mode, PHB and soybean oil feeding strategy enhanced CoQ10 production to 78.2 mg/L.

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Tobacco biomass hydrolysate enhances coenzyme Q10 production using photosynthetic Rhodospirillum rubrum

Cited by 25 publications

References 32 publications

Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis

Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis

Bioactive Compounds from Biomass

Modeling of Process Parameters for Enhanced Production of Coenzyme Q10 FromRhodotorula glutinis

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