To treat snoring with nasal steroids – effects on more than one level?

Hultcrantz, Elisabeth; Harder, Lena; Harder, Henrik; Zetterlund, Eva-Lena; Roberg, Karin

doi:10.3109/00016480902934211

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…The therapeutic use of nasal steroids for snoring has been supported by studies showing the presence of corticosteroid receptors in the upper airway (Friberg et al, 1998), as well as inflammation and swelling due to snoring-associated vibrations (Hultcrantz et al, 2010). However, the previous trials that have examined the potential beneficial effect of nasal steroids on sleep quality and snoring did not all assess snoring objectively (Craig et al, 2005;Kheirandish-Gozal and Gozal, 2008), and none has taken into account the breathing route pattern (Craig et al, 2005;Kheirandish-Gozal and Gozal, 2008;Kiely et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Nasal steroids in snorers can decrease snoring frequency: a randomized placebo‐controlled crossover trial

Koutsourelakis

Keliris

Minaritzoglou

et al. 2014

Journal of Sleep Research

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Summary Although it is anecdotally known that nasal obstruction is associated with snoring, it remains unknown whether the application of nasal steroids could decrease oral/oro‐nasal breathing and increase nasal breathing, and subsequently decrease snoring indices. This study evaluated the effect of nasal budesonide on breathing route pattern and snoring. Twenty‐four snorers were enrolled in a randomized, double‐blind, crossover trial of 1‐week treatment with nasal budesonide compared with 1‐week intervention with nasal placebo. At the start and end of each treatment period, patients underwent nasal resistance measurement and overnight polysomnography with concomitant measurement of breathing route pattern and snoring. Twelve patients were randomly assigned to a 1‐week treatment with nasal budesonide, followed by 2‐week washout period and a 1‐week intervention with the nasal placebo; and 12 patients were randomly assigned to a 1‐week intervention with nasal placebo, followed by 2‐week washout period and a 1‐week treatment with nasal budesonide. Nasal budesonide was associated with a decrease in oral/oro‐nasal breathing epochs and concomitant increase in nasal breathing epochs, decrease of snoring frequency by [median (interquartile range)] 15.8% (11.2–18.8%), and an increase of rapid eye movement sleep; snoring intensity decreased only in patients with increased baseline nasal resistance by 10.6% (6.8–14.3%). The change in nasal breathing epochs was inversely related to the change in snoring frequency (Rs = 0.503; P < 0.001). Nasal budesonide in snorers can increase nasal breathing epochs, modestly decrease snoring frequency and increase rapid eye movement sleep.

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Section: Discussionmentioning

confidence: 99%

Nasal steroids in snorers can decrease snoring frequency: a randomized placebo‐controlled crossover trial

Koutsourelakis

Keliris

Minaritzoglou

et al. 2014

Journal of Sleep Research

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“…Це явище спостерігається в різних пропорціях у різних пацієнтів. Оскільки ніс є першим портом входу вдихуваного повітря в нормальних умовах, патологія носа істотно впливає на повітряний потік і, отже, потенційно сприяє розвитку обструктивного апное сну [8][9][10].…”

Section: оглядиunclassified

The effects of nasal breathing on the development of snoring and apnea

Yaremchuk

2020

OTORHINOLARYNGOLOGY

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Since the nose is the entrance gate of the upper airway, its stuffiness can contribute to sleep disturbance. The results of a number of case-control studies have shown that nasal congestion frequency associated with snoring and mild OSA. However, there is no strong correlation between the degree of nasal obstruction and the severity of OSA. Randomized controlled trials have shown that in patients with rhinitis, both allergic and non-allergic, the use of nasal steroids can improve sleep quality and may be useful for patients with mild OSA, but they themselves are not an adequate treatment. Surgical correction of nasal breathing disorders also reduces the apnea index and improves sleep quality.

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“…В случае сочетания храпа и СОАС с аллергическим ринитом, носовой обструкцией и аденотонзиллярной гипертрофией препаратами выбора являются топиче-ские кортикостероиды [36][37][38][39]. На фоне применения данных препаратов у детей отмечается уменьшение размеров аденоидов и миндалин, улучшаются пара-метры дыхания во сне [36,37].…”

Section: обзор литературыunclassified

“…На фоне применения данных препаратов у детей отмечается уменьшение размеров аденоидов и миндалин, улучшаются пара-метры дыхания во сне [36,37]. Мометазон фуроат разрешен к применению с 2-летнего возраста у детей с аллергическим ринитом, аденотонзиллярной гипер-трофией, храпом и апноэ сна, когда топические кор-тикостероиды используются в качестве первой линии лечения [39].…”

Section: обзор литературыunclassified