To the Question About Pharmacological Protection During Irradiation in Non-infecting Doses: Maybe, Necessary? Part 1. General Overview of Medical-tactical and Phenomenological Aspects

Abstract

Purpose: Review of modern concepts of the biological effect of ionizing radiation in medium doses on a living organism and the consequences of radiation in order to assess the need for the use of drugs suitable for the purpose of modifying the effects; stimulation of discussion on the issue under consideration.
 Results: The conditions of origin and the list of possible radiation effects from irradiation at medium doses of the 0.1–1 Gy range were assessed, the scale and phenomenology of the consequences were assessed as a subject of modification by antiradiation agents.
 Conclusions: Pharmacological support (use of PLC) under conditions of short-term and prolonged irradiation with a low dose rate and in the dose range of 0.2–1 Gy seems to be necessary due to the reality of deterministic effects when the dose limits are exceeded (partly at the premorbid or preclinical level, with pronounced psychogenic reactions – components of the final state), as well as with the possibility of stochastic effects in excess of spontaneous ones, although, according to approximate estimates, with an insignificant frequency.

To the Question about Pharmacological Protection during Irradiation in Non-Infecting Doses: Maybe, Necessary? Communication 3. Review of the Experience of Studying and Prospects for the Use of Anti-Radiation Medicines

“…Особо следует рассмотреть нерадиозащитное действие противолучевых средств. В нашем предыдущем сообщении [103] отмечен психогенный фактор. Ряд препаратов в условиях низкодозового облучения или угрозы такого воздействия обнаружил положительные свойства в отношении этого феномена.…”