To the Editor:

Radermacher, Peter; Calzia, Enrico; McCook, Oscar; Wachter, Ulrich; Szabó, Csaba

doi:10.1097/shk.0000000000001602

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…We feel that Covid-19 is a new territory of research where modulation of H 2 S plays a major role and we wish to thank Rademacher et al ( 1 ) for paving us the way to strengthen our data.…”

mentioning

confidence: 75%

“…We read with great interest the comments addressed by Radermacher et al ( 1 ) on our publication regarding the importance of hydrogen sulfide (H 2 S) for the prognosis and outcome of severe infection caused by the novel SARS-CoV-2 (also known as Covid-19) ( 2 ). Although serum H 2 S levels as high as 249 μM and 580 μM have been demonstrated in patients with septic shock ( 3 ) and severe asthma ( 4 ), we agree that the elevated serum H 2 S is an intriguing finding.…”

mentioning

confidence: 99%

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Reply to Radermacher et al. on “Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus”

Renieris

Katrini

Giamarellos‐Bourboulis

2020

Shock

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“…We feel that Covid-19 is a new territory of research where modulation of H 2 S plays a major role and we wish to thank Rademacher et al ( 1 ) for paving us the way to strengthen our data.…”

mentioning

confidence: 75%

mentioning

confidence: 99%

Reply to Radermacher et al. on “Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus”

Renieris

Katrini

Giamarellos‐Bourboulis

2020

Shock

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“…Therefore, the therapeutic potential for H 2 S donors in their ability to maintain physiological homeostasis attenuating endothelial dysfunction and kidney injury (common disorders in DMT1) in COVID-19 patients, especially STS, may assume particular importance under this condition. A separate discussion is beyond the scope of this paper (66)(67)(68)(69)(70)(71).…”

Section: Discussionmentioning

confidence: 99%

Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1

Gröger

Hogg²,

Abdelsalam³

et al. 2022

Front. Med.

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BackgroundSodium thiosulfate (STS) is a recognized drug with antioxidant and H2S releasing properties. We recently showed that STS attenuated organ dysfunction and injury during resuscitation from trauma-and-hemorrhage in CSE-ko mice, confirming its previously described organ-protective and anti-inflammatory properties. The role of H2S in diabetes mellitus type 1 (DMT1) is controversial: genetic DMT1 impairs H2S biosynthesis, which has been referred to contribute to endothelial dysfunction and cardiomyopathy. In contrast, development and severity of hyperglycemia in streptozotocin(STZ)-induced DMT1 was attenuated in CSE-ko mice. Therefore, we tested the hypothesis whether STS would also exert organ-protective effects in CSE-ko mice with STZ-induced DMT1, similar to our findings in animals without underlying co-morbidity.MethodsUnder short-term anesthesia with sevoflurane and analgesia with buprenorphine CSE-ko mice underwent DMT1-induction by single STZ injection (100 μg⋅g–1). Seven days later, animals underwent blast wave-induced blunt chest trauma and surgical instrumentation followed by 1 h of hemorrhagic shock (MAP 35 ± 5 mmHg). Resuscitation comprised re-transfusion of shed blood, lung-protective mechanical ventilation, fluid resuscitation and continuous i.v. norepinephrine together with either i.v. STS (0.45 mg⋅g–1) or vehicle (n = 9 in each group). Lung mechanics, hemodynamics, gas exchange, acid–base status, stable isotope-based metabolism, and visceral organ function were assessed. Blood and organs were collected for analysis of cytokines, chemokines, and immunoblotting.ResultsDiabetes mellitus type 1 was associated with more severe circulatory shock when compared to our previous study using the same experimental design in CSE-ko mice without co-morbidity. STS did not exert any beneficial therapeutic effect. Most of the parameters measured of the inflammatory response nor the tissue expression of marker proteins of the stress response were affected either.ConclusionIn contrast to our previous findings in CSE-ko mice without underlying co-morbidity, STS did not exert any beneficial therapeutic effect in mice with STZ-induced DMT1, possibly due to DMT1-related more severe circulatory shock. This result highlights the translational importance of both integrating standard ICU procedures and investigating underlying co-morbidity in animal models of shock research.

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“…Finally, an interesting aside, though not directly related to the topic at hand but very relevant to the current global pandemic of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, are the recent reports of reduced H 2 S levels as "a hallmark of COVID-19" [169,236,237] and the therapeutical potential for H 2 S donors; especially STS, in this context, is beyond the scope of this perspective but has been recently reviewed [150,169,[238][239][240].…”

Section: Impact Of Intensive Care Treatment In Pre-clinical Animal Modelsmentioning

confidence: 99%

Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide

Merz

McCook

Denoix

et al. 2021

IJMS

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This paper explored the potential mediating role of hydrogen sulfide (H2S) and the oxytocin (OT) systems in hemorrhagic shock (HS) and/or traumatic brain injury (TBI). Morbidity and mortality after trauma mainly depend on the presence of HS and/or TBI. Rapid “repayment of the O2 debt” and prevention of brain tissue hypoxia are cornerstones of the management of both HS and TBI. Restoring tissue perfusion, however, generates an ischemia/reperfusion (I/R) injury due to the formation of reactive oxygen (ROS) and nitrogen (RNS) species. Moreover, pre-existing-medical-conditions (PEMC’s) can aggravate the occurrence and severity of complications after trauma. In addition to the “classic” chronic diseases (of cardiovascular or metabolic origin), there is growing awareness of psychological PEMC’s, e.g., early life stress (ELS) increases the predisposition to develop post-traumatic-stress-disorder (PTSD) and trauma patients with TBI show a significantly higher incidence of PTSD than patients without TBI. In fact, ELS is known to contribute to the developmental origins of cardiovascular disease. The neurotransmitter H2S is not only essential for the neuroendocrine stress response, but is also a promising therapeutic target in the prevention of chronic diseases induced by ELS. The neuroendocrine hormone OT has fundamental importance for brain development and social behavior, and, thus, is implicated in resilience or vulnerability to traumatic events. OT and H2S have been shown to interact in physical and psychological trauma and could, thus, be therapeutic targets to mitigate the acute post-traumatic effects of chronic PEMC’s. OT and H2S both share anti-inflammatory, anti-oxidant, and vasoactive properties; through the reperfusion injury salvage kinase (RISK) pathway, where their signaling mechanisms converge, they act via the regulation of nitric oxide (NO).

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To the Editor:

Cited by 5 publications

References 12 publications

Reply to Radermacher et al. on “Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus”

Reply to Radermacher et al. on “Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus”

Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1

Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide

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