The important thing is not to stop questioning. Curiosity has its own reason for existence. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery each day.'' -''Old Man's Advice to Youth: 'Never Lose a Holy Curiosity.''' LIFE Magazine (2 May 1955) p. 64 -Albert Einstein As we begin 2021, we are facing a raging global pandemic, political turmoil, social unrest, financial uncertainties, and a backlash against science and reason. Concurrently, we are witnessing the wonders of science, as lifesaving vaccines are developed in record time using completely novel techniques. It is critical during times such as these that we remind ourselves why it is so important to seek the truth, to ask the right questions, to find the answers, and to share the discoveries with others in the spirit of unraveling the ''marvelous structure of reality'' together.We feel especially privileged to write this commentary for the first issue of 2021 that offers a number of exciting highcaliber articles, highlighting the steadfast dedication of scientists around the world to advance the field. This issue features 18 articles including 2 letters to the editor, 8 basic science studies, 6 clinical studies, 1 meta-analysis review, and 1 narrative review.The first two articles are letters to the editor regarding a study that highlighted the role that hydrogen sulfide (H 2 S) plays in acute lung injury within the context of SARS-CoV-2-coronavirus pneumonia (1-3). To broadly recap a prior study, it was found that higher levels of H 2 S were identified among survivor patients with SARS-CoV-2-coronavirus pneumonia (1). However, questions were raised regarding the study's high absolute levels of the H 2 S (2). Welcoming the discussion on their study, the authors offered additional data further supporting their original conclusion that modulation of H 2 S plays a major role in this viral infection (1, 3).Remaining on the topic of the impact of hydrogen-based molecules, Xie et al. ( 4) present their basic science study
