To study the vitamin D levels in infertile females and correlation of Vitamin D deficiency with AMH levels in comparison to fertile females

Lata, Indu; Tiwari, Swasti; Gupta, Amrit; Yadav, Subhash Chandra; Yadav, Sangeeta

doi:10.4103/jhrs.jhrs_105_16

Cited by 19 publications

(24 citation statements)

References 24 publications

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“…Multivariate linear regression analysis of log-transformed AMH and FSH with 25OH-D levels adjusted for age, BMI, and seasonal variation confirmed a lack of association [57]. In a small case-control study by Lata et al [56], women with unexplained infertility were compared to fertile controls in terms of AMH and vitamin D levels. Vitamin D deficiency was present in 64.28% of infertile females.…”

Section: Observational Studiesmentioning

confidence: 85%

“…The current systematic review included eighteen cross-sectional studies and six interventional studies assessing the relationship between serum vitamin D levels and serum AMH levels. The cross-sectional studies demonstrated conflicting results, with several studies finding a positive correlation between serum AMH and vitamin D levels [42,46,50,61], while most studies reported largely negative findings [43][44][45]47,49,[51][52][53][54][55][56][57][58][59]. The systematic review and meta-analysis of the interventional studies revealed that vitamin D supplementations affect serum AMH levels but have opposite effects depending on the ovulatory statuses of the women.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, Bednarska-Czerwińska et al [58] reported a negative correlation between AMH and vitamin D concentrations of up to approximately 30 ng/mL, while beyond that concentration, the trend became positive but statistically insignificant. In addition, differences in the population size may also account for negative findings, as some of the studies had small numbers of patients [43,49,[51][52][53][54]56,58] and were not adequately powered to detect small but significant associations between vitamin D and AMH.…”

Section: Discussionmentioning

confidence: 99%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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Section: Observational Studiesmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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“…Vitamin D was also reported to enhance fertility on other aspects rather than PCOS, it was noted that it improves the success of in-vitro fertilization (12) , and protect against endometriosis (16)(17)(18)(19)(20) .While vitamin D impact on fertility and reproductive health is promising, data available are still inadequate and are not sufficient to establish a solid causal-effect relationship between fertility problems and vitamin D administration or deficiency. Further longitudinal multi-centric studies are still recommended to establish this hypothesis and to generate a consensus for usage of vitamin D in infertile patients.…”

Section: Dicussionmentioning

confidence: 99%

Poly Cystic Ovarian Syndrome and Vit D Correlation with Fertility : Review Article

Alzaidi

Almir

Khormi

et al. 2017

Egyptian Journal of Hospital Medicine

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Over the past few decades, vitamin D was proposed to be highly influential on female fertility and reproductive health. Its role was extensively studied and evaluated specifically in females with polycystic ovarian syndrome. Objectives: the aim of this research was to study the correlation between vitamin D and fertility in general, and in polycystic ovarian syndrome-associated infertility in particular. Methods: we searched Cochrane Library and PubMed for articles addressing the impact and role of vitamin D in fertility issues in females with polycystic ovary disease. Specifically-related topics were carefully reviewed and analyzed to summarize their conclusive results. Results and Discussion: Vitamin D was lower in females with PCOS and vitamin D administration had increased its level, improved metabolic disturbance and shortened inter-menstrual intervals in those patients. Patients with high vitamin D levels had a better success rate of invitro fertilization. However, it did not affect the time to pregnancy in PCOS women. Conclusion: Vitamin D is beneficial for improving metabolic as well as reproductive functions in women with PCOS. It is also essential for successful in-vitro fertilization, and it is probably protective against endometriosis. However, results from different studies are contradictory, and still there is no solid evidence that there is a cause-effect relationship between vitamin D and fertility.

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“…Furthermore, it has been involved in the pathogenesis of various female genital tract and reproductive disorders. [910]…”

Section: Introductionmentioning

confidence: 99%

Vitamin D level and its determinants among Sudanese Women: Does it matter in a sunshine African Country?

Husain

Suliman

Abdelrahman

et al. 2019

J Family Med Prim Care

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Background: Vitamin D deficiency is a worldwide concern. The aim of the current study was to determine the vitamin D level and its contributing factors in Sudanese women. Methods: In this cross-sectional study, 251 Sudanese women attending Family Health Centers in Khartoum, Sudan were interviewed. Following the exclusion of confounding factors, samples from 190 women were analzsed. Serum 25 hydroxyvitamin D “25(OH) D” was quantified using competitive electrochemiluminescence immunoassay. Results: Participants’ age ranged from 18 to 85 years with a mean age (±SD) of 40.2 (±14.06) years. The mean (±SD) vitamin D level was 13.4 (±6.72) ng/ml, ranged 3.00–36.5 ng/ml and the median was 12.7 ng/mL. In total, 157 out of 190 (82.6%) had vitamin D serum levels below 20 ng/ml (deficient); of whom, 52 (27.4%) were in the age group 21–30 years ( P value = 0.228). The correlation between vitamin D level and residence outside Khartoum, sun-exposed face and hands, and face and limbs in comparison with being completely covered were found to be statistically significant ( p values 0.008, 0.023, and 0.036). Conclusion: This study displayed a high percentage (82.6%.) of vitamin D deficiency among women in Sudan, and this in part may indicate that sunshine alone cannot guarantee vitamin D sufficiency in the tropics. Family physicians in tropical countries should screen those with clinical presentations related to vitamin D deficiency.

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To study the vitamin D levels in infertile females and correlation of Vitamin D deficiency with AMH levels in comparison to fertile females

Cited by 19 publications

References 24 publications

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Poly Cystic Ovarian Syndrome and Vit D Correlation with Fertility : Review Article

Vitamin D level and its determinants among Sudanese Women: Does it matter in a sunshine African Country?

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