To Study the Association of the Size and Site of Tympanic Membrane Perforation with the Degree of Hearing Loss

Gupta, Suman Lata; Harshvardhan, Rekha; Samdani, Sunil

doi:10.1007/s12070-017-1102-9

Cited by 9 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One recent study found exclusively posterior perforations had a 12% greater ABG when compared with exclusively anterior perforations, however this was only significant at 500Hz 8 . Another looked at 90 ears and found the mean HL in anterior perforations was 29.9dB compared to the posterior perforation group with 44.9dB 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Many of these studies cite the "phase-cancellation effect" as a factor influencing HL for posterior perforations 8,9,[13][14][15] . This hypothesises that a posterior perforation exposes the round and oval windows simultaneously to sound causing phase-cancellation and further increasing the level of HL 7,21 .…”

Section: Discussionmentioning

confidence: 99%

“…However, perforation site and the effect on hearing is more controversial with contradictory evidence regarding this [6][7][8][9][10][11][12] . Whilst early work showed worse hearing with posteroinferior based perforations 13,14 , others have found posterosuperior defects to be worse 11,15 and more recent work demonstrated no difference between sites 4,6,7,12 . Theories such as loss of the round window baffle effect resulting in phase-cancellation, as well as an increase in ossicular chain abnormalities have been proposed to explain increases in HL with posterior perforations.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Do the size, site and activity of tympanic membrane perforations relate to hearing loss in Aboriginal and Torres Strait Islander children? An observational study.

Morris

Lee

Carney

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: To investigate the effect of size, site and activity of tympanic membrane (TM) perforation on hearing loss (HL) in Aboriginal and Torres Strait Islander (ATSI) children. Design: Observational study Methodology: Children aged 5-18 years who identified as ATSI at 7 Anangu community schools within the APY Lands and Maralinga Lands of South Australia underwent 4 frequency pure-tone audiometry (0.5, 1, 2 and 4kHz) and video-otoscopy (VO). VO data was reviewed by surgeons for a middle ear diagnosis and VO files with TM perforations were then classified by perforation site (AS, AI, PS, PI, A, P, I) and size (<25%, 25–50%, 50–75% or 75–100%). Results: 575 VO files with matching audiological data were obtained. Active perforations (35dBHL; 28-44 IQR) demonstrated greater HL than inactive perforations (31dBHL; 29-39 IQR) p=0.0029. For inactive perforations there was a significant difference between <25% and all larger perforations (p<0.0001) whereas for active perforations the significance changed to between <25% (p<0.0001) and 25-50% (p<0.05) when compared to larger perforations. When perforation site was compared within all size/activity groups, no statistically different findings were identified. In all analyses findings did not change when individual frequencies were compared to 4-frequency pure tone average dBHL. Conclusion: In ATSI children from remote communities HL is greater in ears with larger perforations and active middle ear disease but there was no relationship between perforation site and HL.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Do the size, site and activity of tympanic membrane perforations relate to hearing loss in Aboriginal and Torres Strait Islander children? An observational study.

Morris

Lee

Carney

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Another limitation of transtympanic injection involves the perforation of the TM which can cause scarring that leads to conductive hearing loss. Thus, an administration interval of 1 month was adopted in the electrophysiology study to minimize the effect of TM scarring [ 43 , 44 ]. Consequently, the therapeutic time window estimated within a time frame of 7–14 days was less than or equal to half of the 1-month treatment interval.…”

Section: Discussionmentioning

confidence: 99%

A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss

Pinheiro

Müller

Bös³

et al. 2022

Cell Death Dis

View full text Add to dashboard Cite

Age-related hearing loss (ARHL) is the most common sensory impairment mainly caused by degeneration of sensory hair cells in the cochlea with no causal medical treatment available. Auditory function and sensory hair cell survival critically depend on the Kv7.4 (KCNQ4) channel, a voltage-gated potassium channel expressed in outer hair cells (OHCs), with its impaired function or reduced activity previously associated with ARHL. Here, we investigated the effect of a potent small-molecule Kv7.4 agonist on ARHL in the senescence-accelerated mouse prone 8 (SAMP8) model. For the first time in vivo, we show that Kv7.4 activation can significantly reduce age-related threshold shifts of auditory brainstem responses as well as OHC loss in the SAMP8 model. Pharmacological activation of Kv7.4 thus holds great potential as a therapeutic approach for ARHL as well as other hearing impairments related to Kv7.4 function.

show abstract

“…Chronic suppurative otitis media (CSOM) is a severe health condition that affects people all over the world [1]. Chronic suppurative otitis media is characterized by inflammation of a portion or the entire muco-periosteal layer of the middle ear.…”

Section: Introductionmentioning

confidence: 99%

Relationship of the Size and Location of the Tympanic Membrane Perforation in Chronic Suppurative Otitis Media With the Magnitude of Hearing Loss

Rasouli

Zhapar²

2022

IAM

View full text Add to dashboard Cite

Chronic suppurative otitis media is a severe health condition that affects people worldwide. Perforation in the tympanic membrane reduces the surface area of the membrane available for sound transmission. It's important to identify and treat tympanic membrane perforation as soon as possible, since untreated tympanic membrane perforation contributes to chronic disruptive changes in the middle ear, resulting in further hearing loss, which is a major physical and psychological issue that affects people's lives. The study has been conducted to compare the relationship between the location and size of perforation of the tympanic membrane in chronic suppurative otitis media with the magnitude of hearing loss. The cross-sectional prospective study was conducted among 67 patients who visited the Otorhinolaryngology department for myringoplasty. The study period was from January to April 2021, the age group of patients was between 8 and 43 years old. The number of female participants was 35 (52.2%) and males -32(47.8%) respectively. Average age ±SD was 21.93±9.47 years. Fifty (74.6%) patients had right ear perforation and seventeen (25.4%) with left ear perforation/ It was not statistically significant (χ 2 =22.891; p-value=0.290). Most of the patients were with subtotal of (all quadrants) 30 (44.77%), 2-3 quadrants, and one quadrant perforation were 23 (34.32%) and 14 (20.89%) respectively. Most of the patients, i.e.37 (55.22%), had hearing loss between 26-40dB. There was a significant connection between the perforation size and degree of hearing, (χ 2 =22.891; p-value <0.0001). In one quadrant perforation, greatest hearing loss was on the post inferior quadrant 29.97±4.32 dB. For 2-3 quadrants perforation the hearing loss was greatest in postero-superior combined with postero-inferior perforation 37.42±9,59dB. The most significant hearing loss was in subtotal perforation mean ±SD was 42.13±7.07dB. Hearing loss increases in proportion to the extent of the perforation, post inferior quadrant alone and combined with the post-super were observed with the greatest hearing loss according to the findings of this study.

show abstract

To Study the Association of the Size and Site of Tympanic Membrane Perforation with the Degree of Hearing Loss

Cited by 9 publications

References 13 publications

Do the size, site and activity of tympanic membrane perforations relate to hearing loss in Aboriginal and Torres Strait Islander children? An observational study.

Do the size, site and activity of tympanic membrane perforations relate to hearing loss in Aboriginal and Torres Strait Islander children? An observational study.

A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss

Relationship of the Size and Location of the Tympanic Membrane Perforation in Chronic Suppurative Otitis Media With the Magnitude of Hearing Loss

Contact Info

Product

Resources

About