To Procalcitonin, or Not to Procalcitonin?

Kalil, André C.; Lisboa, Thiago

doi:10.1016/j.chest.2019.02.327

Cited by 7 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Under normal circumstances, procalcitonin can be easily detected within 4 hours and has a half-life span of 20-26 hous. [22] However, it is also synthesized and secreted by systemic tissue cells in microbial infection and other inflammatory reactions such as surgery, tumor and trauma, and so on. The unique biological characteristics make the procalcitonin response to body infection fast and accurate.…”

Section: Discussionmentioning

confidence: 99%

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Lin

Lian

2022

Medicine

View full text Add to dashboard Cite

This study aimed to investigate the effect on the severity and prognostic value of serum procalcitonin for elderly patients with oral and maxillofacial infections. We divided 163 elderly patients with severe oral and maxillofacial infection into survival and death groups according to the prognosis between June 2015 and May 2021, measured serum procalcitonin by enzyme-linked immunosorbent assay on the 1st, 2nd, 3rd, 5th, and 7th day after admission for the dynamic changes of serum procalcitonin level, collected the general physiological and biochemical indexes for the scores of acute physiology and general chronic condition, compared the correlation between serum procalcitonin, mean platelet count and APACHE score, analyzed the prognostic value of serum procalcitonin levels at different time after admission by ROC curve. The serum procalcitonin level increased significantly in both groups after admission, sharply increased at first and then rapidly decreased in the survival group, and continued to rise or declined slowly with fluctuation of high level in the death group. There was a negative correlation between serum procalcitonin level and mean platelet count (r = −0.698, P < .05) and a positive correlation between serum procalcitonin and APACHE II (R = 0.803, P < .05). The ROC curve showed that the serum procalcitonin level had little value on the first day and great value on the third day in predicting the prognosis of elderly patients with severe oral and maxillofacial infection (PCT1d = 0.539, PCT3d = 0.875, P < .05). The serum procalcitonin level is correlated with the severity of the disease in elderly patients with severe oral and maxillofacial space infection. Dynamic observation of it is helpful for the prognosis judgment of patients. After admission, serum procalcitonin level on the third day has a great value for the prognosis judgment of elderly patients with severe oral and maxillofacial space infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Lin

Lian

2022

Medicine

View full text Add to dashboard Cite

show abstract

“…Additionally, PCT monitoring enabled distinguishing the infectious course of sepsis [ 157 – 159 ]. PCT plays a crucial role in guiding the rational use of antibiotics, aiming to reduce antibiotic misuse [ 157 , 160 – 162 ]. In clinical practice, it is recommended to discontinue antibiotics when the serum PCT is <0.25 ng/ml.…”

Section: Clinical Application Of Pct As a Diagnostic Indicatormentioning

confidence: 99%

Progress in Procalcitonin Detection Based on Immunoassay

Huang,

Zu,

Zhang

et al. 2024

Research

View full text Add to dashboard Cite

Procalcitonin (PCT) serves as a crucial biomarker utilized in diverse clinical contexts, including sepsis diagnosis and emergency departments. Its applications extend to identifying pathogens, assessing infection severity, guiding drug administration, and implementing theranostic strategies. However, current clinical deployed methods cannot meet the needs for accurate or real-time quantitative monitoring of PCT. This review aims to introduce these emerging PCT immunoassay technologies, focusing on analyzing their advantages in improving detection performances, such as easy operation and high precision. The fundamental principles and characteristics of state-of-the-art methods are first introduced, including chemiluminescence, immunofluorescence, latex-enhanced turbidity, enzyme-linked immunosorbent, colloidal gold immunochromatography, and radioimmunoassay. Then, improved methods using new materials and new technologies are briefly described, for instance, the combination with responsive nanomaterials, Raman spectroscopy, and digital microfluidics. Finally, the detection performance parameters of these methods and the clinical importance of PCT detection are also discussed.

show abstract

“…Ein sinnvoller Ansatz wäre die Durchführung von Studien zur Erfassung der Häufigkeit antibiotikaassozierter Nebenwirkungen (insbesondere Clostridium-difficile-Infektion, Entwicklung von Multiresistenzen) mit und ohne PCT-Steuerung. Dabei müsste die Protokolladhärenz >80 % in der PCT-gesteuerten Gruppe betragen und einem Vergleich mit einem strikten Antibiotic-Stewardship-Programm standhalten [53].…”

Section: Pct Zur Steuerung Der Antibiotikatherapiedauerunclassified