Prokalzitonin auf der Intensivstation

Grossmann, Soraya de Mattos Camargo; Schroll, S; Pfeifer, M.

doi:10.1007/s00063-020-00703-1

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…There have been some conflicting data about the utility of procalcitonin as a predictor of patient prognosis in clinical. [24,25] Some studies demonstrated a close association between evaluated procalcitonin and the severity of illness. Other studies also showed that the lack of a significant relationship between initial PCT level and patient outcomes is disappointing.…”

Section: Discussionmentioning

confidence: 99%

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Lin

Lian

2022

Medicine

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This study aimed to investigate the effect on the severity and prognostic value of serum procalcitonin for elderly patients with oral and maxillofacial infections. We divided 163 elderly patients with severe oral and maxillofacial infection into survival and death groups according to the prognosis between June 2015 and May 2021, measured serum procalcitonin by enzyme-linked immunosorbent assay on the 1st, 2nd, 3rd, 5th, and 7th day after admission for the dynamic changes of serum procalcitonin level, collected the general physiological and biochemical indexes for the scores of acute physiology and general chronic condition, compared the correlation between serum procalcitonin, mean platelet count and APACHE score, analyzed the prognostic value of serum procalcitonin levels at different time after admission by ROC curve. The serum procalcitonin level increased significantly in both groups after admission, sharply increased at first and then rapidly decreased in the survival group, and continued to rise or declined slowly with fluctuation of high level in the death group. There was a negative correlation between serum procalcitonin level and mean platelet count (r = −0.698, P < .05) and a positive correlation between serum procalcitonin and APACHE II (R = 0.803, P < .05). The ROC curve showed that the serum procalcitonin level had little value on the first day and great value on the third day in predicting the prognosis of elderly patients with severe oral and maxillofacial infection (PCT1d = 0.539, PCT3d = 0.875, P < .05). The serum procalcitonin level is correlated with the severity of the disease in elderly patients with severe oral and maxillofacial space infection. Dynamic observation of it is helpful for the prognosis judgment of patients. After admission, serum procalcitonin level on the third day has a great value for the prognosis judgment of elderly patients with severe oral and maxillofacial space infection.

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Section: Discussionmentioning

confidence: 99%

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Lin

Lian

2022

Medicine

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2021

Aktuelle Urol

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Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View

Jarczak

Kluge

Nierhaus

2020

IJMS

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Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of immunity, inflammation and anti-inflammation is disturbed in a variety of ways. Both pro-inflammatory and anti-inflammatory pathways are upregulated, activation of the coagulation cascade and complement and sepsis-induced lymphopenia occur. Due to the manifold interactions in this network, the use of IgM-enriched intravenous immunoglobulins seems to be a promising therapeutic approach. Unfortunately, there is still a lack of evidence-based data to answer the important questions of appropriate patient populations, optimal timing and dosage of intravenous immunoglobulins. With this review, we aim to provide an overview of the role of immunoglobulins, with emphasis on IgM-enriched formulations, in the therapy of adult patients with sepsis and septic shock.

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Prokalzitonin auf der Intensivstation

Abstract: Prokalzitonin auf der Intensivstation Differenzialdiagnose und Differenzialtherapie EinleitungErsetzen Biomarker das ärztliche Denken oder vermögen sie dieses zu bereichern?

Cited by 3 publications

References 51 publications

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Effect of procalcitonin on the severity and prognostic value of elderly patients with a severe infection of oral and maxillofacial space

Kommentar

Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View

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