To optimize the efficacy of bioheat transfer in capacitive hyperthermia: A physical perspective

Jamil, Muhammad; Ng, Eddie Yin-Kwee

doi:10.1016/j.jtherbio.2013.03.007

Cited by 42 publications

(20 citation statements)

References 22 publications

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“…With regard to the blood perfusion and metabolic heat generation in biological heat transfer, the blood density and the heat capacity were ρ b = 1000 kg/m 3 and c b = 4200 J/(kg K), respectively [28, 36]. Different values for blood perfusion and the metabolic heat of both the liver and the tumor are also listed in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Different values for blood perfusion and the metabolic heat of both the liver and the tumor are also listed in Table 1. The value of the blood perfusion and the metabolic heat of the tumor were both larger than that of the liver because of the specific characteristics of the tumor [16, 28, 36]. The temperature coefficient of electrical conductivity was 1.5%.…”

Section: Methodsmentioning

confidence: 99%

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Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation

Rui

et al. 2016

Med Biol Eng Comput

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High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed here is based on a finite element model of liver tissue with a tumor that has been punctured by a pair of needle electrodes. The pulse voltage used in this study ranges from 1 to 4 kV, the pulse width ranges from 50 to 500 ns, and the repetition frequency is between 100 kHz and 1 MHz. The total pulse length is 100 μs, and the pulse burst repetition frequency is 1 Hz. Blood flow and metabolic heat generation have also been considered. Results indicate that the maximum instantaneous temperature at 100 µs can reach 49 °C, with a maximum instantaneous temperature at 1 s of 40 °C, and will not cause thermal damage during single pulse bursts. By parameter fitting, we can obtain maximum instantaneous temperature at 100 µs and 1 s for any parameter values. However, higher temperatures will be achieved and may cause thermal damage when multiple pulse bursts are applied. These results provide theoretical basis of pulse parameter selection for future experimental researches.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation

Rui

et al. 2016

Med Biol Eng Comput

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“…In order to mine the valuable 3-dimensional heat distribution data based on temperature distribution of body surface, many research groups have carried out in-depth studies and made a series of achievements [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. This present paper aims to acquire the q-r characteristic curve of the heat intensity varying with depth of tomography based on the temperature distribution characteristics of tumor in different stages.…”

Section: Introductionmentioning

confidence: 99%

Q-r curve of thermal tomography and its clinical application on breast tumor diagnosis

Shi¹,

Han²,

Wang³

et al. 2015

Biomed. Opt. Express

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Abstract:Heat is the product following the metabolism of cells, and the metabolism is closely related with the pathological information of living organism. So, there are strong ties between the heat distribution and the pathological state in living organism. In this paper, the mathematical function δ is introduced in the classical Pennes bio-heat transfer equation as the point heat source. By simplifying the boundary conditions, a novel bio-heat transfer model is established and solved in a spherical coordinate system. Based on the temperature distribution of human body surface, the information of heat source is mined layer by layer, and the corresponding q-r curve of heat intensity varying with depth is acquired combining the fitting method of Lorentz curve. According to a large number of clinical confirmed cases and statistics, the diagnostic criteria judging diseases by q-r curve are proposed. Five typical clinical practices are performed and four of the diagnosis results are very consistent with those of molybdenum target (MT) X-ray, B-ultrasonic images and pathological examination, one gives the result of early stage malignant tumor that MT X-ray and B-ultrasonic can't check out. It is a radiation-free green method with noninvasive diagnostic procedure and accurate diagnosis result.

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“…In the case of electric field impact, numerical modeling consists of solving a coupled problem, and, more specifically, analysis of electro-thermal coupling. A tissue model is selected for the mathematical description of heat transfer, namely the classic Pennes model [10] (the most commonly used mathematical model describing the process of heat transfer in living organisms, on a macro scale, which is commonly used in particular to predict temperature changes during hyperthermia, or hypothermia treatments, i.e., broadly understood thermotherapy, e.g., [11][12][13][14][15][16]). The Pennes equation is actually a Fourier heat conduction equation with an additional source component that takes into account the global heat flow effect between blood and the surrounding tissue.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Breast Tumor Destruction Using Fast Heating during Radiofrequency Ablation

Paruch

2019

Materials

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In oncology, hyperthermia is understood as a planned, controlled technique of heating cancerous changes in order to destroy their cells or stop their growth. In clinical practice, hyperthermia is used in combination with radiotherapy, chemotherapy, or immunological therapy. During the hyperthermia, the tissue is typically exposed to a temperature in the range of 40-45 • C, the exception is thermoablation, during which the temperatures reach much higher values. Thermoablation is characterized by the use of high temperatures up to 90 • C. The electrode using the radiofrequency is inserted into the central area of the tumor. Interstitial thermoablation is used to treat, among others, breast and brain cancer. The therapy consists of inducing coagulation necrosis in an area that is heated to very high temperatures. Mathematical modeling is based on the use of a coupled thermo-electric model, in which the electric field is described by means of the Laplace equation, while the temperature field is based on the Pennes equation. Coupling occurs at the level of the additional source function in the Pennes equation. The temperature field obtained in this way makes it possible to calculate the Arrhenius integral as a determinant of the destruction of biological tissue. As a result of numerical calculations regarding the temperature field and the Arrhenius integral, it can be concluded that, with the help of numerical tools and mathematical modeling, one can simulate the process of destroying cancerous tissue.

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To optimize the efficacy of bioheat transfer in capacitive hyperthermia: A physical perspective

Cited by 42 publications

References 22 publications

Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation

Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation

Q-r curve of thermal tomography and its clinical application on breast tumor diagnosis

Mathematical Modeling of Breast Tumor Destruction Using Fast Heating during Radiofrequency Ablation

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