To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double-blind, randomized, controlled trial

Abstract

Background:Azadirachta indica (neem), a Meliaceae family tree, has been used in India for several decades for the treatment of several diseases in medicine and dentistry. Neem has been considered to have antiseptic activity, but still its use for the treatment of gingivitis and periodontitis is not very clear. Hence, the purpose of the present study was to assess the efficacy of neem based mouth rinse regarding its antigingivitis effect.Materials and Methods:Forty five subjects with plaque induced gingivitis were selected for the study. They were equally divided into three groups. Group I patients were asked to rinse with 15 ml of neem mouthwash twice daily, group II with 15 ml of chlorhexidine mouthwash twice daily, and group III with 15 ml of saline twice daily. The three groups were asked to perform the routine oral hygiene procedures thought out the study period. Bleeding on probing and gingivitis were evaluated by Muhlemann and Son's Sulcus bleeding index (1971) and Loe and Sillness gingival index (1963), respectively, at base line, after every week till one month.Results:Our result showed that an A. indica mouthrinse is equally effective in reducing periodontal indices as Chlorhexidine. The results demonstrated a significant reduction of gingival, bleeding, and plaque indices in both groups over a period of 21 days as compared to placebo.Conclusion:A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.

Evaluation of antiplaque and antigingivitis effect of herbal mouthwash in treatment of plaque induced gingivitis: A randomized, clinical trial

“…This study was carried out to see the efficacy of herbal plant mouthwash containing Pilu ( S. persica ), Bibhitaka ( T. bellerica ), Nagavalli , Gandhapura taila , Ela (Cardamomum), Peppermint satva , and Yavani satva in treatment of gingivitis as an adjunct to scaling. Earlier studies shows evidence of usage of herbal mouthwashes such as Turmeric,[14] neem,[15] and triphala,[8] compared to chlorhexidine showed a significant reduction in plaque indices scores, gingival indices scores, and gingival bleeding index scores as in the present study with a value of plaque index (PI) <0.0001, gingival index (GI) <0.0014 and gingival bleeding index (GBI) <0.0001. The effectiveness of herbal mouthrinse likely was due to the ingredients such as Bibhitiki , Pilu , Gandhapura tailum , which has antimicrobial, anti-inflammatory property.…”

The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis: A randomized clinical trial

“…These results correlate with studies done by Southern et al , 2000[10] and Malhotra et al , 2011. [11] However, in a study done by Chatterjee et al , 2011[12] herbal oral rinse is equally effective in reducing periodontal indices as CHX. However, there is not enough statistically significant evidence to suggest that herbal oral rinse had a greater effect in reducing gingival index scores.…”

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

“…Mouthrinse of A . indica used by 45 patients having plaque induced gingivitis showed same effect as chlorhexidine (Chatterjee, Saluja, Singh, & Kandwal, ). Leaves of the tree were used to treat DM in India.…”