To Establish the Reference Intervals of Lipid Profile in Punjab

Kaur, Vaneet Inder; Verma, Minni; Kaur, Amandeep; Gupta, Shalini; Singh, Kamaljit

doi:10.1007/s12291-012-0208-9

Cited by 12 publications

(25 citation statements)

References 16 publications

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“…Recent studies from different geographical locations of India have established reference intervals for certain biochemical parameters and also identified significant changes in liver markers and lipid levels in healthy Indian population [16][17][18][19][20][21]. Furthermore, we have documented that the renal and cell integration markers like creatinine, AST and GGT were lower in females than males as supported by previous studies done elsewhere [22,23].…”

Section: Discussionsupporting

confidence: 84%

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Sairam¹,

Domalapalli

Maruthamuthu

et al. 2013

Ind J Clin Biochem

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Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3-17 g/dL; Females: 9.9-14.3 g/dL), platelet count (Males: 1.3-3.8; Females: 1.3-4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2-22; Females: 4-55 mm/h), serum uric acid in males: 3.5-8.2 mg/dL, gamma glutamyl transferase (Males: 13-61 U/L), fasting blood glucose (Males: 78-110 mg/dL), total cholesterol (Males: 115-254 mg/dL), low density lipoprotein (Males: 60-176 mg/dL) and triglycerides (Males: 55-267 mg/dL, Females: 52-207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies.

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Section: Discussionsupporting

confidence: 84%

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Sairam¹,

Domalapalli

Maruthamuthu

et al. 2013

Ind J Clin Biochem

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“…To the best of our knowledge, this is the first ever large study providing representative age and gender specific percentile values for serum lipids, glucose, blood pressure, and BMI in healthy Gujarati Indians. Contrary to earlier reports where no substantial sex specific difference was noted in the lipid profile [ 11 , 25 ], we had obtained significant difference between the risk profiles of males and females of the study population. The females were having superior CVD risk factor profile due to the estrogenic protective effect, which was found to be lost in the 5th to the 6th decade of life.…”

Section: Discussioncontrasting

confidence: 99%

Age and Sex Specific Reference Intervals for Modifiable Risk Factors of Cardiovascular Diseases for Gujarati Asian Indians

Sahoo

Shah

Konat

et al. 2015

International Journal of Chronic Diseases

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Objective. We aimed to establish age and sex specific percentile reference data for cardiovascular risk factors such as lipids, sugar, blood pressure, and BMI in apparently healthy and disease-free Gujarati population. Methods. In this cross-sectional study, we enrolled 3265 apparently healthy and disease-free individuals of both genders residing in Gujarat state. Fasting samples of blood were used for biochemical estimations of lipids and sugar. The measurement of BMI and blood pressure was also done according to the standard guidelines. Age and gender specific 5th, 25th, 50th, 75th, 90th, and 95th percentiles were obtained. Results. The mean values of lipids, sugar, blood pressure, and BMI were significantly (p < 0.001) higher in males as compared to female population. Age-wise distribution trends showed increase in the risk factors from the 2nd decade until the 5th to 6th decade in most of the cases, where loss of premenopausal protection in females was also observed. Specific trends according to gender and age were observed in percentile values of various parameters. Conclusion. The outcome of current study will contribute significantly to proposing clinically important reference values of various lipids, sugar, blood pressure, and BMI that could be used to screen the asymptomatic Gujarati Indian population with a propensity of developing dyslipidemia, diabetes, blood pressure, and obesity.

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“…Mean body mass index, systolic/ diastolic blood pressure, fasting blood glucose and triglyceride levels in our study have been found to be similar to that reported by other studies, [ 31 , 34 ] but mean total cholesterol levels were lower than earlier reported in literature. [ 24 , 36 – 38 ] No recent population based study reporting mean levels of cholesterol lipoproteins and prevalence of various dyslipidemias in Punjab could be found.…”

Section: Discussionmentioning

confidence: 99%

Profile of Risk Factors for Non-Communicable Diseases in Punjab, Northern India: Results of a State-Wide STEPS Survey

et al. 2016

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BackgroundEfforts to assess the burden of non-communicable diseases risk factors has improved in low and middle-income countries after political declaration of UN High Level Meeting on NCDs. However, lack of reliable estimates of risk factors distribution are leading to delay in implementation of evidence based interventions in states of India.MethodsA STEPS Survey, comprising all the three steps for assessment of risk factors of NCDs, was conducted in Punjab state during 2014–15. A statewide multistage sample of 5,127 residents, aged 18–69 years, was taken. STEPS questionnaire version 3.1 was used to collect information on behavioral risk factors, followed by physical measurements and blood and urine sampling for biochemical profile.ResultsTobacco and alcohol consumption were observed in 11.3% (20% men and 0.9% women) and 15% (27% men and 0.3% women) of the population, respectively. Low levels of physical activity were recorded among 31% (95% CI: 26.7–35.5) of the participants. The prevalence of overweight and obesity was 28.6% (95% CI: 26.3–30.9) and 12.8% (95% CI: 11.2–14.4) respectively. Central obesity was higher among women (69.3%, 95% CI: 66.5–72.0) than men (49.5%, 95% CI: 45.3–53.7). Prevalence of hypertension in population was 40.1% (95% CI: 37.3–43.0). The mean sodium intake in grams per day for the population was 7.4 gms (95% CI: 7.2–7.7). The prevalence of diabetes (hyperglycemia), hypertriglyceridemia and hypercholesterolemia was 14.3% (95% CI: 11.7–16.8), 21.6% (95% CI: 18.5–25.1) and 16.1% (95% CI: 13.1–19.2), respectively. In addition, 7% of the population aged 40–69 years had a cardiovascular risk of ≥ 30% over a period of next 10 years.ConclusionWe report high prevalence of risk factors of chronic non-communicable diseases among adults in Punjab. There is an urgent need to implement population, individual and programme wide prevention and control interventions to lower the serious consequences of NCDs.

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To Establish the Reference Intervals of Lipid Profile in Punjab

Cited by 12 publications

References 16 publications

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals

Age and Sex Specific Reference Intervals for Modifiable Risk Factors of Cardiovascular Diseases for Gujarati Asian Indians

Profile of Risk Factors for Non-Communicable Diseases in Punjab, Northern India: Results of a State-Wide STEPS Survey

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