To compare the gingival melanin repigmentation after diode laser application and surgical removal

Abstract

Aim:The aim of the present study is to compare the gingival melanin repigmentation after diode laser application and surgical removal done by scraping with Kirkland knife.Materials and Methods:This study was a randomized split-mouth study where 10 patients presenting with unattractive, diffuse, dark brown to black gingival discoloration on the facial aspect of the maxillary gingiva were treated by diode laser application and surgical removal and followed up for 3-, 6-, and 9-month intervals.Results:The results showed a statistically significant difference in repigmentation between the groups at the interval of 3 months (P = 0.040), but the difference was statistically not significant at 6 months (P = 0.118) and 9 months (P = 0.146). On surgically treated sites, all cases showed repigmentation of the gingiva, but in laser treated, there were two individuals which did not show repigmentation of the gingiva even at the end of 9-month observation time.Conclusion:The incidence of repigmentation was slightly less in laser-treated sites as compared to surgical depigmentation although the difference was statistically significant only up to 3 months.

RETRACTED ARTICLE: Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway

“…The Wnt/β-catenin and BMP pathways have been shown to be essential in the osteogenic differentiation of BMSCs [4,8]. When Wnt ligands bind the receptors LRP5/6 and Frizzled receptors, the classical Wnt/β-catenin pathway is activated, after which formation of the Wnt-fz-lrp6 complex (including Axin, APC, GSK3, and CK1) promotes the release of β-catenin [9][10][11][12][13]. Ultimately, β-catenin migrates to the nucleus, where it forms a complex with TCF/LEF to stimulate the expression of osteogenic genes, such as RUNX2, ALP, DLX5, and OCN [14,15].…”

Most effective method for the management of physiologic gingival hyperpigmentation: A systematic review and meta-analysis

“…A total of 4989 studies with relevant titles were further scrutinized based on eligibility criteria. After removing studies on basis of irrelevant objective, protocols only, no abstract, no full text, in vitro studies, different study designs, only 25 studies[12131421222324252627282930313233343536373839404142] were finally selected to be included for data extraction. The PRISMA flow chart of the process is shown in Figure 1.…”

Assessment of Clinical Outcomes and Patient Response to Gingival Depigmentation by Scalpel Surgical Stripping and Diode Laser: A Randomized Split-Mouth Study

“…The scalpel surgical technique is a pioneering technique and is very popular till date due to the ease of application, easy availability of armamentarium, and affordability. 2 The procedure involves the surgical removal of gingival epithelium along with a layer of the underlying connective tissue, thereby allowing the denuded connective tissue to heal by secondary intention. The new epithelium that forms is devoid of melanin pigmentation.…”

“…The new epithelium that forms is devoid of melanin pigmentation. 2,3 Laser techniques have, however, replaced the conventional surgical stripping. 14,15 The present study was carried out to compare the depigmentation techniques of surgical stripping and diode laser.…”

“…In medical sciences, various depigmentation techniques have been employed with similar clinical results. In 2017, a similar study was carried out by Mahajan et al 2 in which they compared depigmentation by the scalpel technique on one side and by the diode laser technique on the other side, and concluded that, on surgically treated sites, all cases showed repigmentation of the gingiva, but those treated with the laser technique did not show repigmentation of the gingiva even at the end of the 9-month observation time. The selection of a technique should be based on clinical experience and individual preferences.…”