TNFα gene/protein in tumorigenesis of sporadic colon adenocarcinoma

Kapitanović, Sanja; Čačev, Tamara; Ivković, Tina Catela; Lončar, Božo; Aralica, Gorana

doi:10.1016/j.yexmp.2014.08.003

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…We found no significant association between TNF - α -308 polymorphism and CRC patients in the overall analysis. Our results are in agreement with other investigations that did not find a correlation between TNF - α -308 and sporadic colon cancer in a Spanish population [ 42 ], a Hungarian population [ 43 ], a Korean population [ 39 ], and a Croatian population [ 23 ]. In addition, TNF - α -308 polymorphism was not associated with colon cancer in any European population in a meta-analysis conducted by Fan et al, 2011 [ 44 ].…”

Section: Discussionsupporting

confidence: 93%

“…In our study, the distribution of the three genotypes in the Saudi population (CC/CT/TT—cases 85/15/0, controls 85/15/0) were different compared to a Croatian population (CC/CT/TT—cases 130/64/6, controls 126/67/7) [ 23 ]. Moreover, significant correlation between the TNF- α mRNA expression level in CRC tumor tissue, and prevalence of TNF - α -857 CT and TT genotypes were reported and may be involved in the progression of colon cancer [ 23 ]. The differences in the distribution of genotype frequencies of TNF - α -857 could be due to the ethnic diversity between the two populations.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicated that TNF-α-related cellular functions were influenced by polymorphism in the promoter region of the TNF - α gene [ 20 – 22 ]. Recently, TNF - α was suggested to be one of the immunomodulatory genes in the progression of sporadic CRC [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer

et al. 2015

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Tumor necrosis factor-alpha (TNF-α) contributes in inflammation and has been implicated in the development of colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) in TNF-α promoter could affect the risk of CRC by regulating TNF-α production. This is the first study to investigate TNF-α SNPs in a Middle Eastern population. In this study, we examined three SNPs in TNF-α for association with CRC. One hundred CRC patients and 100 controls were genotyped for TNF-α -308, -238, and -857 using TaqMan allelic discrimination assay. The TNF-α -238 (G/A) genotype was significantly associated with high risk of CRC (p = 0.003552). The distribution of three genotypes of -238 G/A was significantly different between the controls and CRC patients even after Bonferroni’s correction. The AA genotype of -238 G/A SNP was observed at considerably higher proportion (13 %) in CRCs compared to controls (1 %). Additionally, similar to genotypes, the allelic frequencies of -238 G/A were significantly different between the CRC cases and controls (odds ratios (OR) = 7.647, χ 2 = 18.50, p = 0.00002). The genotype frequencies of -308 and -857 were not notably different between the cases and controls. TNF-α -238A may be useful as a screening marker to identify individuals prior to their acquiring CRC in the Saudi population although, further validations in larger cohorts are needed.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer

et al. 2015

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“…A previously reported, cancer-related function for this protein could be to mediate tumor progression by inducing proliferation, invasion, and metastasis of tumor cells. Higher levels of TNFA have been correlated with advanced tumor stage and shorter survival in several cancer studies . In particular, TNFA has been associated with tumor stage in UBC. − Clearly, further investigations are required to confirm the discriminative power of these protein candidates as prognosis markers for patients with a prior history of UBC.…”

Section: Resultsmentioning

confidence: 99%

“…Higher levels of TNFA have been correlated with advanced tumor stage and shorter survival in several cancer studies. 68 In particular, TNFA has been associated with tumor stage in UBC. 69−71 Clearly, further investigations are required to confirm the discriminative power of these protein candidates as prognosis markers for patients with a prior history of UBC.…”

Section: Journal Of Proteome Researchmentioning

confidence: 99%

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

et al. 2017

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Urothelial bladder cancer is a condition associated with high recurrence and substantial morbidity and mortality. Noninvasive urinary tests that would detect bladder cancer and tumor recurrence are required to significantly improve patient care. Over the past decade, numerous bladder cancer candidate biomarkers have been identified in the context of extensive proteomics or transcriptomics studies. To translate these findings in clinically useful biomarkers, the systematic evaluation of these candidates remains the bottleneck. Such evaluation involves large-scale quantitative LC-SRM (liquid chromatography-selected reaction monitoring) measurements, targeting hundreds of signature peptides by monitoring thousands of transitions in a single analysis. The design of highly multiplexed SRM analyses is driven by several factors: throughput, robustness, selectivity and sensitivity. Because of the complexity of the samples to be analyzed, some measurements (transitions) can be interfered by coeluting isobaric species resulting in biased or inconsistent estimated peptide/protein levels. Thus the assessment of the quality of SRM data is critical to allow flagging these inconsistent data. We describe an efficient and robust method to process large SRM data sets, including the processing of the raw data, the detection of low-quality measurements, the normalization of the signals for each protein, and the estimation of protein levels. Using this methodology, a variety of proteins previously associated with bladder cancer have been assessed through the analysis of urine samples from a large cohort of cancer patients and corresponding controls in an effort to establish a priority list of most promising candidates to guide subsequent clinical validation studies.

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Association between the 308 G>A variant of the TNF-α gene and risk of colorectal cancer

et al. 2021

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TNFα gene/protein in tumorigenesis of sporadic colon adenocarcinoma

Cited by 7 publications

References 20 publications

Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer

Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

Association between the 308 G>A variant of the TNF-α gene and risk of colorectal cancer

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