TNFα-exposed Bone Marrow-derived Mesenchymal Stem Cells Promote Locomotion of MDA-MB-231 Breast Cancer Cells through Transcriptional Activation of CXCR3 Ligand Chemokines

Shin, Soon Young; Nam, Jeong‐Seok; Lim, Yoongho; Lee, Young Han

doi:10.1074/jbc.m110.128124

Cited by 72 publications

(81 citation statements)

References 51 publications

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“…Previous results showed that CXCL10 promoter activity was stimulated by TNF-α which was mediated through NF-κB cis acting reaction component within the CXCL- First two authors contributed equally 10 promoter at mesenchymal stem cells (Shin et al, 2010). The binding site NF-κB disruption within the CXCL10 promoter in Caco-2 cells almost totally eradicated TNF-α inducibility of CXCL10 promoter activity and also the ectopic responses of NF-κB nullified TNF-α induced CXCL10 promoter activity.…”

Section: Discussionmentioning

confidence: 99%

“…After 24 hours, cells present on the filter top were detached using cotton-swabs and the remaining cells that are located in the bottom filters were subjected for staining and then followed by extraction and quantification at 560 nm as per the instructions given in the manufacture's kit. This method was performed based on the reported literature (Shin et al, 2010).…”

Section: Invasion Assaymentioning

confidence: 99%

“…Later, these blots were treated with the antibodies as per the experimental method (Shin et al, 2010). Caco-2 cells were also lysed based on this reported method.…”

Section: Western Blotmentioning

confidence: 99%

“…The CXCL 10 production was induced by the tumor necrosis factor -α which is potent to be participated in cancer cell invasion (Shin et al, 2010). The current study deals to establish the role of phytochemicals as well as its potential target towards the human colon cancer.…”

mentioning

confidence: 99%

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Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression

Dai

Kong

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Effective immunomodulator and pro-inflammatory cytokine, Tumor necrosis factor-α (TNF-α) are considered to be responsible for connecting autoimmune pathological process and contagious diseases. TNF-α stimulates the C-X-C motif chemokine 10 (CXCL10) expression that is participated in migration of tumor, metastasis, and invasion. Tectorigenin, an o-methylated isoflavone, is present as a major portion in the Iris tectorum rhizomes. In this study, we investigated the tectorigenin effects as an anticancer drug. The obtained results showed that tectorigenin hinders the invasion of human colon cancer cells (Caco-2). We used reverse transcription PCR, q-PCR and enzyme linked immunosorbent assays to test whether the tectorigenin is involved in the inhibition of TNF-α induced CXCL-10 expression in the Caco-2 cell lines. Further, we tested TNF-α induced NF-κB activity using the tectorigenin. Collective results showed that tectorigenin inhibits the CXCL10 production by using TNF-α via NF-κB inhibition.</p><p> </p>

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Section: Discussionmentioning

confidence: 99%

Section: Invasion Assaymentioning

confidence: 99%

“…Later, these blots were treated with the antibodies as per the experimental method (Shin et al, 2010). Caco-2 cells were also lysed based on this reported method.…”

Section: Western Blotmentioning

confidence: 99%

mentioning

confidence: 99%

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Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression

Dai

Kong

et al. 2015

Bangladesh J Pharmacol

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“…TGF (transforming growth factor ) was found to stimulate MSCs to secrete more IL-6, IL-8, angiopoietin-2, G-CSF, HGF, VEGF and PDGF-BB (De Luca et al, 2010). TNF forced MSCs to increase their expression of CXCL9, CXCL10 and CXCL11 (Shin et al, 2010). Exposure of MSCs to conditioned medium from tumor cells also stimulate expression of chemokines, such as CXCL2 and CXCL12 (Menon et al, 2007).…”

Section: The Cytokine Cocktail Secreted By Mscsmentioning

confidence: 99%

Involvement of Mesenchymal Stem Cells in Breast Cancer Progression

Dittmer¹,

Oerlecke²,

Leyh³

2011

Breast Cancer - Focusing Tumor Microenvironment, Stem Cells and Metastasis

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Immune mediated support of metastasis: Implication for bone invasion

Xin,

Qin,

Tang

et al. 2024

Cancer Communications

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Bone is a common organ affected by metastasis in various advanced cancers, including lung, breast, prostate, colorectal, and melanoma. Once a patient is diagnosed with bone metastasis, the patient's quality of life and overall survival are significantly reduced owing to a wide range of morbidities and the increasing difficulty of treatment. Many studies have shown that bone metastasis is closely related to bone microenvironment, especially bone immune microenvironment. However, the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear. Here, we described the changes in various immune cells during bone metastasis and discussed their related mechanisms. Osteoblasts, adipocytes, and other non‐immune cells closely related to bone metastasis were also included. This review also summarized the existing treatment methods and potential therapeutic targets, and provided insights for future studies of cancer bone metastasis.

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TNFα-exposed Bone Marrow-derived Mesenchymal Stem Cells Promote Locomotion of MDA-MB-231 Breast Cancer Cells through Transcriptional Activation of CXCR3 Ligand Chemokines

Cited by 72 publications

References 51 publications

Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression

Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression

Involvement of Mesenchymal Stem Cells in Breast Cancer Progression

Immune mediated support of metastasis: Implication for bone invasion

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