Involvement of Mesenchymal Stem Cells in Breast Cancer Progression

Dittmer, J; Oerlecke, Ilka; Leyh, Benjamin

doi:10.5772/21325

Cited by 5 publications

(7 citation statements)

References 170 publications

(250 reference statements)

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“…These results are interesting because many authors have confirmed that RANKL, IL-6, SDF-1, and CCL-2 released by tumor cells (among others) are spindle-shaped SC-attracting factors (eg, MSC or TAF). 33,34,[36][37][38][39] Finally, we found a significant positive association between TRAIL, RANKL, and CCL-2 expression in spindle-shaped SC and TRAIL-R1 and R4, RANK, and CCR-2 in TEpC, respectively. These last results, along with the findings of other authors, suggest that the spindle-shaped SC through RANKL and CCL-2 could influence the proliferation, survival, invasion, migration, and intravasation of TEpC at an early stage of the disease.…”

Section: Vivian Labovsky Et Alsupporting

confidence: 61%

“…These associations among RANKL/RANK, IL-6/IL-6R, SDF-1/CXCR-4, and CCL-2/CCR-2 could be important in the context of SC proliferation and migration. 23,28,[32][33][34][35] However, future studies need to be undertaken to further describe the exact role and mechanism driven by these associations.…”

Section: Vivian Labovsky Et Almentioning

confidence: 99%

“…These last results, along with the findings of other authors, suggest that the spindle-shaped SC through RANKL and CCL-2 could influence the proliferation, survival, invasion, migration, and intravasation of TEpC at an early stage of the disease. 33,34,[40][41][42] In addition, these factors could induce the EMT of TEpC, a phenotype that induces hormone therapy resistance. 33,40,41 Our data show that breast tumorigenesis is a multifaceted process involving change in the expression of ligands and R in both TEpC and spindle-shaped SC.…”

Section: Vivian Labovsky Et Almentioning

confidence: 99%

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Association Between Ligands and Receptors Related to the Progression of Early Breast Cancer in Tumor Epithelial and Stromal Cells

Labovsky¹,

Martinez²,

Davies

et al. 2015

Clinical Breast Cancer

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Section: Vivian Labovsky Et Alsupporting

confidence: 61%

Section: Vivian Labovsky Et Almentioning

confidence: 99%

Section: Vivian Labovsky Et Almentioning

confidence: 99%

See 1 more Smart Citation

Association Between Ligands and Receptors Related to the Progression of Early Breast Cancer in Tumor Epithelial and Stromal Cells

Labovsky¹,

Martinez²,

Davies

et al. 2015

Clinical Breast Cancer

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“…In breast cancer, the vast majority of studies on paracrine effects of stem cells have been done with MSCs which by heavily communicating with breast cancer cells via many soluble factors are able to promote tumor progression ( 26 , 104 ). Interestingly, MSCs may also affect breast CSCs.…”

Section: Paracrine Effects Of Stem Cells In Cancermentioning

confidence: 99%

Paracrine effects of stem cells in wound healing and cancer progression

Dittmer¹,

Leyh²

2014

International Journal of Oncology

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Stem cells play an important role in tissue repair and cancer development. The capacity to self-renew and to differentiate to specialized cells allows tissue-specific stem cells to rebuild damaged tissue and cancer stem cells to initiate and promote cancer. Mesenchymal stem cells, attracted to wounds and cancer, facilitate wound healing and support cancer progression primarily by secreting bioactive factors. There is now growing evidence that, like mesenchymal stem cells, also tissue-specific and cancer stem cells manipulate their environment by paracrine actions. Soluble factors and microvesicles released by these stem cells have been shown to protect recipient cells from apoptosis and to stimulate neovascularization. These paracrine mechanisms may allow stem cells to orchestrate wound healing and cancer progression. Hence, understanding these stem cell-driven paracrine effects may help to improve tissue regeneration and cancer treatment.

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“…CAFs, a type of activated fibroblasts, can be generated from different cell types, among which is the mesenchymal stem cell (MSC) [ 10 ]. MSCs are commonly residing in the bone marrow and are attracted to wounds and cancer lesions [ 11 , 12 ]. Once having entered a cancer lesion, they start interacting with the tumor cells, which most often leads to cancer progression.…”

Section: Introductionmentioning

confidence: 99%

Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis

et al. 2015

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There is strong evidence that stromal cells promote drug resistance of cancer. Here, we show that mesenchymal stem cells (MSCs) and carcinoma-associated fibroblasts (CAFs) desensitize ERα-positive breast cancer cells to the anti-estrogen fulvestrant. In search for the mechanism, we found that MSCs and CAFs similarly increased the activity of the PI3K/AKT and the JAK/STAT3 pathways and upregulated the expression of integrin β1, IGF1R, HIF1α, CAIX and Bcl-3 in MCF-7 cells. Further analyses revealed that MSCs and CAFs coordinately induce these changes by triggering the downregulation of IGFBP5. Loss of IGFBP5 in MCF-7 cells was an early and long-lasting event in response to MSCs and CAFs and was accompanied by growth stimulation both in the absence and presence of fulvestrant. The growth-stimulatory effect in the absence of fulvestrant could be attributed to PI3K/AKT pathway activation and could be mimicked by insulin. The growth-promoting effect in the presence of fulvestrant depended upon the upregulation of Bcl-3. By cRNA microarray analysis we identified additional IGFBP5 targets, of which two (KLHL4 and SEPP1) were inversely regulated by IGFBP5 and Bcl-3. BT474 cells also responded to stromal cells by downregulating IGFBP5 and upregulating the P-AKT, Bcl-3 and IGF1R levels, whereas T47D cells did not show any of these responses. In conclusion, our data suggest that, by targeting IGFBP5 expression in ERα-positive breast cancer cells, such as MCF-7 cells, MSCs and CAFs are able to orchestrate a variety of events, particularly activation of the PI3K/AKT pathway, upregulation of Bcl-3 expression and desensitization to anti-estrogen.

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Involvement of Mesenchymal Stem Cells in Breast Cancer Progression

Cited by 5 publications

References 170 publications

Association Between Ligands and Receptors Related to the Progression of Early Breast Cancer in Tumor Epithelial and Stromal Cells

Association Between Ligands and Receptors Related to the Progression of Early Breast Cancer in Tumor Epithelial and Stromal Cells

Paracrine effects of stem cells in wound healing and cancer progression

Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis

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