Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Vroman, Heleen; Uden, Denise van; Bergen, Ingrid M.; Hulst, Jennifer A C van; Lukkes, Melanie; Loo, Geert; Clausen, Björn E.; Boon, Louis; Lambrecht, Bart N.; Hammad, Hamida; Hendriks, Rudolf W.; Kool, Mirjam

doi:10.1111/all.14334

Cited by 10 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 An activated status in epithelial CD141+ mDCs increases interferon (IFN)γ availability, thus protecting from Th2-cell priming. 34 Moreover, plasmacytoid DCs are relevant sources of type I IFN and also protect from viral respiratory infections. 35 IL-13 is a truly pleiotropic cytokine for its heterogeneity of cellular source and downstream functions.…”

Section: T2 Asthmamentioning

confidence: 99%

“…CD141+ mDC are specialized in antigen cross‐presentation and are crucial for antiviral defence 33 . An activated status in epithelial CD141+ mDCs increases interferon (IFN)‐γ availability, thus protecting from Th2‐cell priming 34 . Moreover, plasmacytoid DCs are relevant sources of type I IFN and also protect from viral respiratory infections 35 .…”

Section: Asthma Pathophysiological Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Advances and highlights in asthma in 2021

Agache

Eguiluz‐Gracia

Cojanu

et al. 2021

Allergy

View full text Add to dashboard Cite

Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality realworld evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.

show abstract

Section: T2 Asthmamentioning

confidence: 99%

Section: Asthma Pathophysiological Mechanismsmentioning

confidence: 99%

Advances and highlights in asthma in 2021

Agache

Eguiluz‐Gracia

Cojanu

et al. 2021

Allergy

View full text Add to dashboard Cite

show abstract

“…In the light of the above, Tolerant/2 nM detected DEGs may play a role in long-term protection. This set of DEGs includes under-expressed genes that reinforce DC tolerogenic behaviour, such as typical DC activation markers, Ccr7 32 and Cd83 33 , including also Cxcr4 34 , Cytip 35 , Il6st 36 , Rel 37 , 38 , Smad7 39 , 40 , Pde4b 41 , Cd14 21 , Zbtb10 42 , Sik1 43 and Tnfaip3 44 , 45 . Moreover, multiple over-expressed genes concur with DC tolerogenic behaviour: Alg3 46 , Il2ra 47 and Uhfr1 48 , 49 .…”

Section: Discussionmentioning

confidence: 99%

Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model

Núñez

Rodríguez

Palomares

et al. 2022

Sci Rep

View full text Add to dashboard Cite

To investigate food allergy-tolerance mechanisms induced through allergen-specific immunotherapy we used RNA-Sequencing to measure gene expression in lymph-node-derived dendritic cells from Pru p 3-anaphylactic mice after immunotherapy with glycodendropeptides at 2 nM and 5 nM, leading to permanent tolerance and short-term desensitization, respectively. Gene expression was also measured in mice receiving no immunotherapy (anaphylaxis); and in which anaphylaxis could never occur (antigen-only). Compared to anaphylaxis, the antigen-only group showed the greatest number of expression-changes (411), followed by tolerant (186) and desensitized (119). Only 29 genes changed in all groups, including Il12b, Cebpb and Ifngr1. The desensitized group showed enrichment for genes related to chronic inflammatory response, secretory granule, and regulation of interleukin-12 production; the tolerant group showed genes related to cytokine receptor activity and glucocorticoid receptor binding, suggesting distinct pathways for similar outcomes. We identified genes and processes potentially involved in the restoration of long-term tolerance via allergen-specific immunotherapy, representing potential prognostic biomarkers.

show abstract

“…It differs in murine normal tissue for that the expression of langerin was described in mouse cDC1 in view that the co-expressing CD103 (also named αE integrin) is a marker of cDC1 in mouse peripheral tissues ( 16 , 17 ). Specifically, langerin was reported expressed by 15% of cDC1s in the murine lung ( 18 ).…”

Section: The Expression and Characteristics Of Langerin In Mnpsmentioning

confidence: 99%

“…Moreover, signaling by another Notch ligand JAG2 induces differentiation of CD14 + monocytes into LCH-like cells ( 25 ). In addition, inhibition of TNFAIP3, the negative regulator of NF-κB signaling affects Th cell differentiation in the presence of pulmonary langerin + DCs ( 18 ).…”

Section: The Expression and Characteristics Of Langerin In Mnpsmentioning

confidence: 99%

Langerin-expressing dendritic cells in pulmonary immune-related diseases

Xuan

et al. 2022

Front. Med.

View full text Add to dashboard Cite

Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture. DCs are divided into various subclasses according to their differential expression of cell surface receptors and different subclasses of DCs exhibit specific immunological characteristics. Exploring the common features of each sub-category has became the focus of many studies. There are certain amounts of DCs expressing langerin in airways and peripheral lungs while the precise mechanism by which langerin+ DCs drive pulmonary disease is unclear. Langerin-expressing DCs can be further subdivided into numerous subtypes based on the co-expressed receptors, but here, we identify commonalities across these subtypes that point to the major role of langerin. Better understanding is required to clarify key disease pathways and determine potential new therapeutic approaches.

show abstract

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 10 publications

References 50 publications

Advances and highlights in asthma in 2021

Advances and highlights in asthma in 2021

Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model

Langerin-expressing dendritic cells in pulmonary immune-related diseases

Contact Info

Product

Resources

About