TNF-α gene polymorphisms in Iranian Azeri Turkish patients with Behcet’s Disease

Bonyadi, Mortaza; Jahanafrooz, Zohreh; Esmaeili, Mohsen; Kolahi, Sousan; Khabazi, Alireza; Ebrahimi, Ali; Hajialilo, Mehrzad; Dastgiri, Saeed

doi:10.1007/s00296-009-1134-x

Cited by 42 publications

(36 citation statements)

References 27 publications

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“…The frequencies of TNF-α -238 G/G and G/A genotypes were 6.2% and 93.8% in BD patients, 6.3% and 93.7% in healthy controls and the allele frequencies of TNF-α -238G were 0.53 in BD patients and 0.54 in healthy controls ( P = 0.500; OR = 0.96; 95% CI = 0.53–1.73). In previous study, we have already shown a significant association of BD with TNF-α -1031C allele ( P = 0.001; OR = 3.08; 95% CI = 1.73–5.47) in the same patients that we further studied in this research (21). …”

Section: Resultssupporting

confidence: 54%

Polymorphisms of Promoter Region ofTNF-αGene in Iranian Azeri Turkish Patients with Behçet’s Disease

Abdolmohammadi

Bonyadi

2017

J Korean Med Sci

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Behçet’s disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-α gene polymorphisms (at the positions of -238 and -857). A total number of 166 Iranian subjects were enrolled into two different groups; patients with BD (n = 64), and ethnically matched healthy controls (n = 101). The genotype distributions of BD patients and healthy controls were determined. The frequency of TNF-α -857C allele was significantly higher in Behçet’s patients than that of healthy controls (P = 0.001; odds ratio [OR] = 2.616; 95% confidence interval [CI] = 1.129–6.160), whereas the frequency of TNF-α -238A allele was similar in both groups. The sole TNF-α haplotype-857C-1031C, was associated with an increase in the risk of developing BD. The TNF-α -857C allele was considerably associated with BD in this cohort. The findings of this study, collectively, indicate that TNF-α -857C-1031C haplotype located in the promoter region of the gene could exert major influence on the susceptibility to BD.

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Section: Resultssupporting

confidence: 54%

Polymorphisms of Promoter Region ofTNF-αGene in Iranian Azeri Turkish Patients with Behçet’s Disease

Abdolmohammadi

Bonyadi

2017

J Korean Med Sci

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“…The lower frequency of allele A of TNF-α (-308G/A) has been reported in North European Caucasian and Korean patients with CD or UC as compared to healthy controls [103]. Although the frequency of allele G was reported to be slightly higher in Iranian Azeri Turkish IBD patients, it did not reach statistical significance [110]. Further, no association of TNF-α(-308G/A) polymorphism with IBD susceptibility was found in Australian [82], Brazilian [60,130], Canadian [100], Chinese [106,131], Czech [132], French [133], Indian [108], Korean [115], Newfoundland [27], Spanish [126], and Turkish [120] populations.…”

Section: Discussionmentioning

confidence: 81%

Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Al-Robayan¹,

Arfin²,

Meghaiseeb³

et al. 2016

New Insights Into Inflammatory Bowel Disease

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“…In large series, -308G/A and 238 GA polymorphisms of TNF-α were associated with asthma, systemic lupus erythematosus and juvenile RA in pediatric Mexican population [21]. Bonyadi [22] determined that allele and genotype distributions of -1031T/C polymorphism was significantly different in Behçet's disease of Iranian Azeri Turks. Vargas-Alarcon reported that -308A/G allel was increased in undifferentiated spondyloarthropathy group [23].…”

Section: Discussionmentioning

confidence: 99%

Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report

Turgay¹,

Aydeniz²,

Pehlıvan³

et al. 2017

Pau Med J

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Purpose:The aim of this study was to explore the association between promotor polymorphisms in tumor necrosis factor α (TNF-α) gene and disease activity,clinical parameters and response to different treatments in rheumatoid arthritis patients. Materials and methods:We analyzed single nucleotide polymorphisms (-308,-238 and -857) in TNF-α gene in 65 patients with active RA who were treated with DMARD or anti-TNF therapy and in 70 control ones who had no rheumatologic problems.TNF-α genotyping were performed by the PCR-RFLP method.Clinical responses were compared by using disease activity score,VAS and health assessment questionnaire at baseline and after 6 months of treatment. Results:A significant positive association was observed at TNF-857 CC genotype in RA patients (p=0.046). At the six months the mean VAS,HAQ and DAS 28 improvement was not significant among groups.Improvement in DAS score was significantly better in -308 GG genotype than -308 AG genotype in anti-TNF subgroup. Conclusion:Our results suggest that TNF-857 CC genotype may be associated with susceptibility to disease and polymorphism in TNF-308 genotype may have an effect in response to therapy.Further studies should be warranted to establish TNF-α polymorphisms and susceptibility and response to treatment inrheumatoid arthritis patients.Pam Med J 2017; 10 (3):216-220 Keywords:Rheumatoid arthritis,TNF-α, gene,promoter polymorphisms. ÖzetAmaç:Bu çalışmanın amacı romatoid artrit hastalarında tümör nekrozis alfa geni (TNF-α) promotor polimorfizmi ile hastalık aktivitesi,klinik parametreler ve değişik tedavilere yanıt arasında ilişkiyi belirlemektir. Gereç ve yöntem:Çalışmamızda DMARD veya anti-TNF tedavisi alan 65 aktif romatoid artrit hastası ve 70 romatolojik hastalığı olmayan kontrol grubunda -308,-238,-857 içeren TNF-α'nın tek nukleotid polimorfizmi PCR-RFLP yöntemi kullanılarak analiz edildi.Tedaviye klinik yanıt hastalık aktivite skoru,görsel analog ölçek ve sağlık değerlendirme anketi kullanılarak başlangıçta ve 6 aylık tedavi sonrasında değerlendirildi. Bulgular:Romatoid artrit hastalarında TNF-857 CC genotipinin anlamlı olarak fazla olduğu saptandı.Altı aylık tedavi sonunda grupların VAS;HAQ ve hastalık aktivite skorlarında iyileşme benzer bulundu.Buna rağmen hastalık aktivite skorlarında iyileşme TNF grubundaki hastalarda -308 GG genotipi olanlarda -308 AG genotipi olanlara göre daha iyiydi. Sonuç:Romatoid artrit hastalarında TNF-857 CC genotipinin hastalığı yatkınlık sağlayabileceği;Aynı zamanda -308 genotinideki polimorfizmin tedaviye yanıtta bir rolü olabilir.Romatoid artrit hastalarında TNF-α polimorfizmi ve hastalığa yatkınlık ve tedaviye yanıtın belirlenmesinde ileri çalışmalara gereksinim vardır. Tıp Derg 2017; 10 (3):216-220 Pam

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TNF-α gene polymorphisms in Iranian Azeri Turkish patients with Behcet’s Disease

Cited by 42 publications

References 27 publications

Polymorphisms of Promoter Region ofTNF-αGene in Iranian Azeri Turkish Patients with Behçet’s Disease

Polymorphisms of Promoter Region ofTNF-αGene in Iranian Azeri Turkish Patients with Behçet’s Disease

Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report

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