TNF-α effect on human delivery onset by CB1/TRPV1 crosstalk: new insights into endocannabinoid molecular signaling in preterm vs. term labor. Analysis of the EC/EV pathway and predictive biomarkers for early diagnosis of preterm delivery

Torella, Annalaura; Bellini, Giulia; Punzo, Francesca; Argenziano, Maura; Schiattarella, Antonio; Labriola, Domenico; Schettino, Maria Teresa; Ambrosio, Domenico; Ammaturo, Franco Pietro; Franciscis, Pasquale De

doi:10.23736/s0026-4784.19.04405-8

Cited by 14 publications

(11 citation statements)

References 45 publications

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“…We hypothesise that in TLM without contractions, an abnormal level of secreted IL‐8 may contribute to early ripening of the cervix and initiate the procedure of giving birth. An investigation of cell‐signaling pathways in female reproduction found that TNFα can be a biomarker of delivery onset 21 . Other immune biomarkers in our study were not found to have independent effects on late miscarriage.…”

Section: Discussioncontrasting

confidence: 63%

Amniotic immune biomarkers as risk factors in women with different symptoms of threatened late miscarriage

Meng

Wang

Reilly

et al. 2020

American J Rep Immunol

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Problem:To investigate risk factors that can help identify the possibility of pregnancy loss in threatened late miscarriage (TLM) patients with and without spontaneous uterine contractions. Method of study:Amniotic immune biomarkers (IL2β receptor, IL6, IL8, IL10, IL1β, and TNFα) were assayed, and "sludge" was assessed. Patients without intrauterine infections were treated and followed up until delivery, and pregnancy outcomes were recorded. The two groups were compared for the differences in biomarker levels and "sludge," and the independent associations of biomarkers, "sludge," and other maternal factors with late miscarriage were investigated. Results:The amniotic levels of IL2βR, IL8, and TNFα were higher in the group with contractions (P < .05). When considered alone, each of the six biomarkers was significantly associated with late miscarriage in the no-contractions group and four of these (IL8, IL10, IL1β, and TNFα) in the contractions group (P < .05). Biomarker levels were correlated, and in multivariate Cox regression analysis, there was an independent effect only for IL8 in the no-contractions group (HR = 18.16, 95% CI: 5.75-57.43) andTNFα in the contractions group (HR = 4.11, 95% CI: 1.68-10.08). For patients with contractions, IL10, IL8, and IL1β were different in those with and without "sludge," but no such difference was seen in the no-contractions group. Conclusion:For TLM patients without intrauterine infections, amniotic immune biomarkers differ between patients with different symptoms, not only for their levels but also for the impact of these biomarkers on the risk of late miscarriage. These findings suggest that the symptoms of TLM should be considered in the study of miscarriage risk. K E Y W O R D S amniotic fluid sludge, IL6, IL8, independent risk factors, threatened late miscarriage, transvaginal ultrasoundThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 63%

Amniotic immune biomarkers as risk factors in women with different symptoms of threatened late miscarriage

Meng

Wang

Reilly

et al. 2020

American J Rep Immunol

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“…Our group examined CB 1 R and CRIP1a in human uterine and placental tissue obtained during cesarean deliveries, and we found a significant reduction in CB 1 R protein in uterine tissue obtained during labor compared to non-labor. Torrela and colleagues evaluated CB 1 R, CB 2 R, transient receptor potential vanilloid receptor type 1 (TRPV1), FAAH, NAPE-PLD, monoacylglycerol lipase (MAGL) and diacylglycerol lipase (DAGL) in human placental samples obtained after spontaneous vaginal deliveries using qPCR ( 36 ). Compared to samples obtained at 30 weeks gestation (preterm), there was a significant increase in CB 1 R mRNA at term.…”

Section: Cannabinoid Receptor Influence In Pregnancy and Labormentioning

confidence: 99%

Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review

2021

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The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as placentation. The current theory behind the initiation of term labor is that it is a complex, multifactorial process involving sex steroid hormones, prostaglandin production and interplay at the maternal-fetal interface resulting in increased expression of receptors and gap junctions that promote uterine activation. There is increasing evidence that, in addition to early pregnancy events, the ECS plays a regulatory role in pregnancy maintenance and the timing of labor. This review presents an overview of the ECS in pregnancy that focuses on late gestation and parturition.

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“…However, the usage of tocolytic agents for preterm labor is disputed among obstetricians worldwide, and professional organizations have established various guidelines which vary greatly in their recommendations [ 14 ]. To emphasize, preterm birth is still a challenge to researchers studying its basic mechanisms, and though there have been some recent headways into its molecular pathways and prediction models [ 15 ], the question of when to start tocolytic therapy and for how long remains a common but difficult decision for clinicians. Currently, it is generally recommended that tocolysis be limited to the occurrence of preterm labor between the gestational ages (GA) of 24 weeks and 30 weeks or to those over 30 weeks of GA accompanied with cervical length <15 mm or 20 mm [ 4 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Tocolytic Treatment for the Prevention of Preterm Birth from a Taiwanese Perspective: A Survey of Taiwanese Obstetric Specialists

Lee

Yeh

Yang

et al. 2022

IJERPH

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Preterm birth represents a great burden to the healthcare system, resulting in the consideration for the use of tocolytic therapy to provide a “better time” for delivery in order to buy time to accelerate fetal lung maturity, thereby minimizing prematurity-related morbidity and mortality. However, the benefits and potential side effects and risks of tocolytic treatment for preterm birth should be carefully balanced. Although many countries and societies provide guidelines or consensuses for the management for preterm birth, there is no standardized national guideline or consensus in Taiwan. As such, great heterogeneity is suspected in preterm labor management, contributing to the uncertainty of attitudes and practice patterns of obstetric specialists in Taiwan. This study attempts to understand the attitudes and practice patterns regarding tocolytic therapy in Taiwan. A paper-based survey was conducted at the 2020 Taiwan Society of Perinatology Conference on 8 December 2020, exploring how obstetric specialists would use tocolytics under nine different clinical scenarios, such as a short cervix, preterm labor, maintenance tocolysis, preterm premature rupture of membranes, etc. Three hundred ten specialists attended the conference, and 77 responded to the survey with a response rate of 24.8%. According to the survey, many of these specialists would prescribe tocolytics for less evidence-based indications, including 22% for abdominal tightness, 46% for a short cervix, 60% for maintenance tocolysis, and 89% for repeat tocolysis, with the preferred first line medication being ritodrine and nifedipine. We concluded that tocolysis is widely accepted and practiced in Taiwan. More research is needed to include Taiwan-specific economic and cultural factors as well as associated adverse effects and patients’ outcomes.

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TNF-α effect on human delivery onset by CB1/TRPV1 crosstalk: new insights into endocannabinoid molecular signaling in preterm vs. term labor. Analysis of the EC/EV pathway and predictive biomarkers for early diagnosis of preterm delivery

Cited by 14 publications

References 45 publications

Amniotic immune biomarkers as risk factors in women with different symptoms of threatened late miscarriage

Amniotic immune biomarkers as risk factors in women with different symptoms of threatened late miscarriage

Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review

Tocolytic Treatment for the Prevention of Preterm Birth from a Taiwanese Perspective: A Survey of Taiwanese Obstetric Specialists

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