Tnf-α− 308A Promoter Polymorphism Is Associated With Enhanced Tnf-α Production and Inflammatory Activity in Crohn's Patients With Fistulizing Disease

González, Segundo; Rodrigo, Luís; Martínez‐Borra, Jesús; López-Vázquez, Antonio; Fuentes, Dolores; Niño, Pilar; Cadahía, Valle; Saro, Cristina; Dieguez, M.; López‐Larrea, Carlos

doi:10.1111/j.1572-0241.2003.07416.x

Cited by 80 publications

(80 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These 11 studies contained a combined total of 2000 CD patients and 3499 healthy controls. Sample sizes in the 11 studies varied from 150-846 and publication years were from 1999-2014 (Negoro et al, 1999;González et al, 2003;Balding et al, 2004;Fowler et al, 2005;Song et al, 2005;Zipperlen et al, 2005;Fidder et al, 2006;Yang et al, 2006;Mittal et al, 2007;Hradsky et al, 2008;López-Hernández et al, 2014). Of these, 7 studies were conducted in Caucasians and the other 4 studies were in Asians.…”

Section: Resultsmentioning

confidence: 99%

Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

Yq¹,

Sq²,

Gao³

2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn's disease (CD) using a metaanalysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant published studies. The studies retrieved from database searches were filtered based on inclusion and exclusion criteria, and the resultant data extracted from the selected studies were analyzed using the Comprehensive Meta-analysis 2.0 software. Eleven case-control studies, containing 2000 CD patients and 3499 healthy controls, were identified as relevant to this meta-analysis. Data extracted from these 11 studies were analyzed to understand the role of the 2 TNF-α polymorphisms in CD. We found that the TNF-α rs1799724 C>T (2015) polymorphism increased the susceptibility to CD (allele model: OR = 1.293, 95%CI = 1.090-1.534, P = 0.003; dominant model: OR = 1.258, 95%CI = 1.031-1.534, P = 0.024). In contrast, we found no significant association between the TNF-α rs1800629 G>A polymorphism and CD susceptibility (allele model: OR = 1.005, 95%CI = 0.864-1.170, P = 0.945; dominant model: OR = 0.962, 95%CI = 0.809-1.145, P = 0.667). This meta-analysis showed that the TNF-α rs1799724 C>T polymorphism is associated with CD susceptibility, while the TNF-α rs1800629 G>A polymorphism appeared to have no correlation with the susceptibility to CD.

show abstract

Section: Resultsmentioning

confidence: 99%

Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

Yq¹,

Sq²,

Gao³

2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Epidemiological data have shown that up to a quarter of patients became steroiddependent and 20% steroid-resistant within 1 year [28]. Although the mechanism of steroid resistance is unclear, it is known that TNF-α levels are increased in carriers of the uncommon -308A allele [26] and TNF-α was demonstrated to induce dysregulation of the intestinal barrier regulating the tight junctions (TJ) leading to increased permeability. A number of study have suggested that the elevated levels of TNF-α present in CD patients are responsible for the observed increases in intestinal permeability seen in these patients [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

“…Genomic DNA samples were extracted from peripheral blood leukocytes, according to standard protocols [26] and genotyped at the Molecular Laboratory of the Unit of Gastroenterology of the San Giovanni Rotondo Hospital, Italy.…”

Section: Genotypingmentioning

confidence: 99%

A Polymorphism of the Tnf-α Gene Promotes Steroid-Resistance In patients with Inflammatory Bowel Disease

Annese¹

2016

JGPLD

View full text Add to dashboard Cite

“…Furthermore, among the three TNFα promoter haplotypes resolved, AG haplotype was over represented in our CD cohort as compared with control subjects (OR=1,89; CI=1,02; 3,50). According to our data, selected studies of SNPs in the TNF promoter region have been found to be associated with IBD [31][32][33]. A Japanese study reported a significantly increased incidence of polymorphisms in the promoter region of the TNFα at positions -1031, -863, and -857 in patients with CD, versus ethnically matched controls [34,35] in a study on Korean patients observed a significantly higher frequency of -238A allele of TNF-α in CD patients with perianal lesions compared with patients without perianal disease.…”

Section: Discussionmentioning

confidence: 99%

Replication of Identified Inflammatory Bowel Diseases Genetic Associations: A Case–Control Study in the Tunisian Population

Bouzid¹

2013

J Clin Cell Immunol

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBD) -Crohn's disease (CD) and ulcerative colitis (UC) -are chronic gastrointestinal inflammatory disorders with a complex genetic background. A genome wide association scan by the Welcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci. We performed a replication study in 107 IBD patients (39 CD and 68 UC) and 162 controls. In total, 19 single nucleotide polymorphisms (SNPs) from previously identified susceptibility genes PTPN11, TNF α, IL23R, PTPN2, PTPN22, IL2 and IL10 were studied. In UC, we confirmed the association with PTPN2 (rs254215, GG, P=0.013, P corr =0.039; OR= 6.23 (1.18; 32.95)). In CD, we confirmed a marginal association with ((rs11066320, GG, P=0.018, P corr =0.054, OR= 0.4 (0.19; 0.82)). No significant association was found at the allele and genotype levels of SNPs in TNF α, IL23R, PTPN22, IL2, and IL10. However, on the haplotype analysis the AG haplotype of TNFα was more frequent in CD patients compared to controls (23.1% vs. 13.7%; P = 0.039; OR= 1.89 (1.02; 3.5)). The PTPN11 ATG haplotype was also more frequent in CD patients compared to controls (32.1% vs 21.3%; P = 0.04; OR= 1.75 (1.01; 3.01). These results reveal limited replication in Tunisian population and indicate differences in genetic architecture between populations.

show abstract

Tnf-α− 308A Promoter Polymorphism Is Associated With Enhanced Tnf-α Production and Inflammatory Activity in Crohn's Patients With Fistulizing Disease

Abstract: TNF-alpha -308A polymorphism is associated with enhanced TNF-alpha production, more intense inflammatory activity, and an increased risk for arthritis susceptibility in CD patients with fistulizing disease.

Cited by 80 publications

References 33 publications

Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

A Polymorphism of the Tnf-α Gene Promotes Steroid-Resistance In patients with Inflammatory Bowel Disease

Replication of Identified Inflammatory Bowel Diseases Genetic Associations: A Case–Control Study in the Tunisian Population

Contact Info

Product

Resources

About