Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

Abstract

ABSTRACT. We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn's disease (CD) using a metaanalysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant published studies. The studies retrieved from database searches were filtered based on inclusion and exclusion criteria, and the resultant data extracted from the selected studies were analyzed using the Comprehensive Meta-analysis 2.0 software. Eleven case-control studies, containing 2000 CD patients and 3499 healthy controls, were identified as relevant to this meta-analysis. Data extracted from these 11 studies were analyzed to understand the role of the 2 TNF-α polymorphisms in CD. We found that the TNF-α rs1799724 C>T (2015) polymorphism increased the susceptibility to CD (allele model: OR = 1.293, 95%CI = 1.090-1.534, P = 0.003; dominant model: OR = 1.258, 95%CI = 1.031-1.534, P = 0.024). In contrast, we found no significant association between the TNF-α rs1800629 G>A polymorphism and CD susceptibility (allele model: OR = 1.005, 95%CI = 0.864-1.170, P = 0.945; dominant model: OR = 0.962, 95%CI = 0.809-1.145, P = 0.667). This meta-analysis showed that the TNF-α rs1799724 C>T polymorphism is associated with CD susceptibility, while the TNF-α rs1800629 G>A polymorphism appeared to have no correlation with the susceptibility to CD.

Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis

“…The present study reveals that compared with the CC genotype, the rs1799724 CT genotype is a risk factor for pAIH. Despite conflicting data regarding rs17999724 and autoimmune diseases, the findings agree with meta-analyses of diseases such as ankylosing spondylitis [20], Crohn’s disease [21] and vitiligo [18] using additive, dominant, and allele models. In contrast, a lack of this association was documented for idiopathic nephrotic syndrome [30] and rheumatoid arthritis [31].…”

“…Overexpression of TNF-α in AIH patients’ sera has been reported, with the level directly correlating with prognosis [19]. In addition, the TNF promoter polymorphism rs1799724 (c.-1037C > T) has been associated with autoimmune diseases, such as ankylosing spondylitis and Crohn’s disease [20], [21] and with susceptibility to hepatitis B virus infection in some populations [22].…”

Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients

“…Six of the SNPs in the BAT1-NFKBIL1-LTA region (rs2071591, rs3093949, rs2071592, rs2239527, rs909253, and rs1041981) have been reported in association with various inflammatory and autoimmune disorders including rheumatoid arthritis (RA) 10 , myocardial infarction 11 , and Grave’s disease 12 . TNF-α rs1800629 polymorphism was reported to be an associated risk for coronary heart disease and myocardial infarction 13 and Crohn’s disease 14 . C6orf10 rs2050190 was associated with coronary artery disease 15 , MSH5 rs3131379 and rs3131378 in systemic lupus erythematosus (SLE) 16 , and MICA rs2523451 was reported as a marker for RA 17 .…”

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset

“…The SNP rs1800629 in TNF is linked to various autoimmune diseases, including CD, celiac disease, RA, and SLE (6,(19)(20)(21). Another SNP in the TNF gene rs1799724 is associated with CD and autoimmune hepatitis (AIH) (22,23). Higher serum levels of TNFα were shown in carriers of the TNF rs1799724 risk genotype, while for the SNP rs1800629, data on an association with elevated TNFα serum levels are inconclusive (6,24).…”