TNF y citocinas y dolor: más allá de la inflamación tisular

Moreno-Brea, M.R.; Micó, Juan Antonio

doi:10.1016/j.reuma.2009.05.001

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…For example, pro-inflammatory cytokines such as IL-1 β and IL-6 are higher during the active phase, while the anti-inflammatory cytokines reach their peak during the resting phase [23,24]. Further studies suggested that cytokines play a major role in pain perception, and thereafter, pro-inflammatory cytokine modulation is vital for pain management and tissue recovery [25].…”

Section: Introductionmentioning

confidence: 99%

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Pérez-González

Abusamak

Sáez-Alcaide

et al. 2022

Oral Maxillofac Surg

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Purpose To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.

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Section: Introductionmentioning

confidence: 99%

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Pérez-González

Abusamak

Sáez-Alcaide

et al. 2022

Oral Maxillofac Surg

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“…Cytokines help repair injuries, eliminate pathogens, and maintain health. However, they can cause hypersensitivity reactions in tissues and act as proinflammatory, anti-inflammatory mediators, or both [29]. During an inflammatory process, granulocytes are recruited into damaged tissue, producing inflammatory mediators, including pro-inflammatory cytokines such as TNFα, IL-1β, IL-6, maintaining an acute inflammatory response until the cause is eliminated [36].…”

Section: Resultsmentioning

confidence: 99%

ANALGESIC ED50 DICLOFENAC-EUGENOL COMBINATION EFFECT ON PROINFLAMMATORY CYTOKINES – IL-1β, IL-6, TNFα AND MAPKs – IN RAT MUSCLE

GONZÁLEZ-LUGO¹

2022

FARMACIA

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Inflammation is a typical response to a wide variety of stressors, including xenobiotics, which can develop a prolonged, severe, and inappropriate inflammatory response that can lead to events at the molecular level degenerating into adverse effects. The objective of the study was to evaluate the effect of ED 50 diclofenac-eugenol (DFC+EUG) combination on proinflammatory cytokines (IL-1β, IL-6, TNFα and MAPKs) in rat muscle. The treatments as well as the control solutions were administered in the gastrocnemius muscle and the expression of cytokines and MAPKs was evaluated through an endpoint PCR. There were no significant changes in the expression of IL-6, TNFα and MAPKs in healthy rats. In contrast, a statistically significant increase was shown in the relative expression of IL-1β when DFC+EUG was administered vs. the control group. The expression of IL-1β decreased in the group DFC+EUG by the addition of Aloe vera. The obtained data suggested that the DFC+EUG combination causes a moderate increase in the expression of the proinflammatory cytokines IL-1β, but not for the expression of IL-6, TNFα and MAPKs in healthy rats. RezumatInflamația este un răspuns tipic la o mare varietate de factori de stres, inclusiv la xenobiotice, care pot dezvolta un răspuns inflamator prelungit, acesta generând efecte moleculare nedorite. Obiectivul studiului a fost evaluarea efectului combinației DE 50 diclofenac-eugenol (DFC+EUG) asupra citokinelor proinflamatorii (IL-1β, IL-6, TNFα și MAPK-uri) în mușchiul de șobolan. Tratamentele, precum și soluțiile de control, au fost administrate în mușchiul gastrocnemius și expresia citokinelor și MAPK-urilor a fost evaluată prin tehnica PCR. Nu au existat modificări semnificative în expresia IL-6, TNFα și MAPKurilor la șobolanii sănătoși. S-a constatat o creștere semnificativă din punct de vedere statistic a expresiei relative a IL-1β atunci când s-a administrat DFC+EUG față de grupul control. Expresia IL-1β a scăzut în grupul DFC+EUG după adăugarea de Aloe vera. Datele obținute au sugerat că DFC+EUG determină o creștere moderată a expresiei citokinelor proinflamatorii IL-1β, dar nu și a expresiei IL-6, TNFα și MAPK-urilor la șobolanii sănătoși.

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“…Los autores argumentan que dichas citocinas pudieran ser las encargadas de la modulación de la sintomatología de la enfermedad. 11 La obesidad tiene efectos sobre la calidad de vida de las personas con padecimientos que provocan dolor crónico. Un IMC elevado se relaciona con un aumento del dolor crónico, discapacidad, depresión y una función física reducida.…”

Section: Introductionunclassified

Relación entre la composición corporal y sintomatología en mujeres de Aguascalientes que padecen fibromialgia

Santillán¹,

Ramírez²,

Hermosillo³

et al. 2021

LUXMED

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Introducción: La fibromialgia es una enfermedad con diversas complicaciones que afectan el estado nutricio. Niveles composición corporal alterados, (exceso de adiposidad o sarcopenia) son condicionantes para el control y aparición de manifestaciones clínicas. Objetivo: Describir la asociación de la composición corporal y la sintomatología de fibromialgia. Materiales y métodos: Estudio descriptivo transversal, en el que participaron 27 mujeres con fibromialgia de Aguascalientes, México. Se realizó el cuestionario sobre los efectos de la fibromialgia (FIQ) para recolectar datos de sintomatología; para la composición corporal se utilizó una báscula de control corporal OMRON HBF-514C analizando peso, masa grasa, masa muscular y grasa visceral. Resultados: Con un IMC de 28.9±5.4. Se clasificó en desnutrición, normopeso, sobrepeso y obesidad (3.7%, 25.9%, 29.6% y 40.7% respectivamente,) El 66.7% de las pacientes presentaron porcentaje muy elevado de grasa, el 22.9% obtuvo porcentaje elevado y solo el 11.1% presento un porcentaje normal para su edad. No hubo diferencias entre un porcentaje de grasa normal, elevado y muy elevado, ni en el IMC en relación con el puntaje total del FIQ. La relación entre la composición corporal y las variables clínicas obtenidas en el FIQ demostraron que no hay relación significativa. Conclusiones: No hubo relación significativa entre la composición corporal y la sintomatología de fibromialgia, sin embargo, existe evidencia que demuestra lo contrario. La prevalencia de obesidad y sobrepeso es alta en pacientes con fibromialgia, es importante continuar estudios para establecer la relación que existe entre estas condiciones, generando a futuro un adecuado tratamiento integral.

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TNF y citocinas y dolor: más allá de la inflamación tisular

Cited by 6 publications

References 14 publications

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

ANALGESIC ED50 DICLOFENAC-EUGENOL COMBINATION EFFECT ON PROINFLAMMATORY CYTOKINES – IL-1β, IL-6, TNFα AND MAPKs – IN RAT MUSCLE

Relación entre la composición corporal y sintomatología en mujeres de Aguascalientes que padecen fibromialgia

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