Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Abstract

Purpose To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.

Chronotherapy in dentistry: A scoping review

“…morning and afternoon administration only) was reported to be of potential therapeutic benefit for post-operative recovery after wisdom tooth extraction (Tamimi et al 2022). This finding was also in accordance with a recent study, published after our search was conducted, investigating the same outcomes but in a cross-over design (Pérez-González et al 2022). However, these RCTs had relatively small sample size which could influence their reported findings.…”