TNF Polymorphisms in Patients with Behçet Disease: A Meta-analysis

Touma, Zahi; Farra, Chantal; Hamdan, Ayad; Shamseddeen, Wael; Uthman, Imad; Hourani, Hala; Arayssi, Thurayya

doi:10.1016/j.arcmed.2010.02.002

Cited by 53 publications

(38 citation statements)

References 21 publications

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“…First, this study was performed in BD patients from eastern Asia. Despite similar clinical manifestations in different ethnic groups,35 the results of candidate gene analysis, including HLA-B51, has shown different results according to ethnicities 5 36. Therefore, our result may not be applicable to other ethnic groups.…”

Section: Discussionmentioning

confidence: 71%

Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease

et al. 2012

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Section: Discussionmentioning

confidence: 71%

Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease

et al. 2012

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“…However, these studies have produced contradictory results. A meta-analysis was recently performed on polymorphisms in TNF-a at positions -238, -308, -857, -863, and -1031; the authors reported that the polymorphisms at positions -238A, -857T, and -1031C are significantly associated with BD [52] and those at -238A and -1031C increase the risk of BD [odds ratio (OR) 1.35 and 1.51, respectively], whereas the one at -857T decreases the risk of BD (OR 0.76). Moreover, mononuclear cells from CC genotype carriers at TNF-a position -1031 have been found to produce higher levels of TNF-a than those of other genotype carriers when stimulated with lipopolysaccharides [53].…”

Section: Tnf Genementioning

confidence: 98%

Behçet’s disease and genes within the major histocompatibility complex region

Song

Kang

2011

Mod Rheumatol

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The role of genetic background in the development of Behçet's disease (BD) is best reflected by the strong association between HLA-B*51 and BD that has been demonstrated across various ethnic groups. The contributions made by other HLA or non-HLA genes to disease susceptibility have been suggested by the results of a number of gene association studies, although the true associations between the genes located within the major histocompatibility complex (MHC) region and BD have often been doubted due to the possibility of linkage disequilibrium of those genes with HLA-B*51. The presence of a true susceptibility gene in the vicinity of HLA-B*51 has also been extensively investigated because of the limited evidence that directly relates HLA-B*51 to the pathogenesis of BD. However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51. In this review, we discuss BD-associated genes within the MHC region and their biological roles in the pathogenesis of BD.

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“…87 Meta-analyses confirmed an association of TNF-α polymorphisms with BD in various ethnic populations. 56,57,88 …”

Section: Genetic Advances On Genes Involved In Th1 Cell Pathwaysmentioning

confidence: 98%